CAS: 483-76-1; (1S,8Ar)-1-Isopropyl-4,7-Dimethyl-1,2,3,5,6,8A-Hexahydronaphthalene

相似化合物

1610-39-5 747-90-0 469-61-4

上下游产品

formic acid (-)-germacra-1(10),5(E)-dien-4β-ol α-copaene 4-epi-cubebil Tetrahydr°Cadinen (+)-γ-cadinene γ-cadinene (-)-Calamenene

Farnesyl Pyrophosphate置于δ-Cadinene Synthase体系中,用98%的收率获得产物(1S,8Ar)-1-异丙基-4,7-二甲基-1,2,3,5,6,8A-六氢萘
参考文献:δ-卡二烯合酶的 β 结构域中的氨基末端片段对催化至关重要†
标题:δ-卡二烯合酶的 β 结构域中的氨基末端片段对催化至关重要†
摘要:尽管距离活性位点很远,但植物倍半萜环化酶 δ-卡二烯合酶 (Dcs) β 结构域中的柔性氨基末端片段 (Nts) 对于催化过程中的活性位点关闭和去溶剂化事件至关重要.
DOI:10.1039/c6Ob01398H

专利信息

专利号:US-2021206711-A1
优先权日:2020-01-03
标 题:Synthesis of the Grape Mealybug Pheromone trans-alpha-Necrodyl Isobutyrate
发明人：CHEBNY VINCENT JAMES
权利人:TRECE INC
摘要:Methods are provided for synthesizing the grape mealybug pheromone, trans-α-necrodyl isobutyrate, starting with essential plant oils that contain trans-α-necrodyl acetate. The synthesis method, in two steps, converts the trans-α-necrodyl acetate to trans-α-necrodol and then converts the trans-α-necrodol to the desired trans-α-necrodyl isobutyrate. The first step can be achieved by either of a hydrolysis reaction or a reduction reaction. In the hydrolysis reaction, the essential oil is mixed in an alcohol solvent with a hydroxide base, or by mixing the essential oil in an aqueous acid. A reduction reaction can instead by performed in an organic solvent in the presence of a reducing agent. The trans-α-necrodol is converted to the desired trans-α-necrodyl isobutyrate by an esterification reaction with a carboxylic acid, an acyl halide, or an acid anhydride.

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

专利号:US-7914823-B2
优先权日:2000-12-21
标题 :Method and composition for the topical treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD ALLEN
权利人:PROPHASE LABS INC
摘要:A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recovery of the damaged nerve tissues.

专利号:RO-137792-A2
优先权日:2022-05-13
标题:PROCEDURE FOR THE SYNTHESIS AND CHARACTERIZATION OF DETECTION MOLECULES USED FOR THE DEVELOPMENT OF RAPID IMMUNOCROMATOGRAPHIC TESTS