CAS: 179055-20-0; (4-(1-Methyl-1H-Pyrazol-3-yl)Phenyl)Methanol

相似化合物

179055-27-7 915707-39-0 179057-11-5

上下游产品

CAS号179057-11-5 4-(1-甲基-1H-吡唑-3... | CAS号38430-55-6 4-乙酰基苯甲酸甲酯 | CAS号114431-72-0 4-(3-(二甲氨基)丙烯酰基... | CAS号179055-27-7 4-(1-甲基-1H-吡唑-3...

📜4-[(2E)-3-(二甲基氨基)-1-氧代-2-丙烯-1-基]苯甲酸甲酯置于二异丁基氢化铝,溶剂黄146体系中,用 二氯甲烷,甲苯 用作溶剂,化学反应 3.5H,反应生成4-(1-甲基-1H-吡唑-3-基)苯甲醇
参考文献:酰基辅酶a的抑制剂:胆固醇o-酰基转移酶.2.新系列的n-烷基-N-(杂芳基取代的苄基)-N'-芳基脲的鉴定和结构-活性关系.
标题:酰基辅酶a的抑制剂:胆固醇o-酰基转移酶.2.新系列的n-烷基-N-(杂芳基取代的苄基)-N'-芳基脲的鉴定和结构-活性关系.
摘要:制备了一系列n-烷基-N-(杂芳基取代的苄基)-N'-芳基脲和相关的衍生物(用2和3表示),并对其在体外和体外抑制酰基辅酶a:胆固醇o-酰基转移酶的能力进行了评估.降低体内胆固醇喂养大鼠的血浆胆固醇水平.在这些新型化合物中,3型系列更为出色.该三取代脲的n-苄基上的吡唑-3-基(即3,Ar1 =吡唑-3-基)被鉴定为杂芳环,提供了非常好的生物活性.通过优化与n-烷基(R)和n-芳基(ar3)的组合的结果,化合物3Aq(fr186054)被确定为一种新型的口服有效acat抑制剂,在胆固醇喂养的大鼠中表现出有效的体外acat抑制活性(兔子肠道微粒体ic50 = 99 Nm)和出色的降胆固醇作用,而与给药方式无关(ed50 = 0.046 Mg / Kg,通过饮食给药,Ed50 = 0. 44 Mg /通过在peg400载体中的管饲法施用1Kg).此外,一项毒理学研究表明,以10 Mg / Kg
Doi:10.1021/jm9800853

专利信息

专利号:US-6664282-B2
优先权日:1999-09-17
标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
发明人：ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:US-5856107-A
优先权日:1997-02-04
标 题 :Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein
发明人：OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.

专利号:US-6313327-B1
优先权日:1999-07-09
标题 :Carboxylic acid derivatives and their synthesis method
发明人：SEO DONG SEOUL; PARK JOO HYEON; KIM JAE YOUNG; KIM SEONG JU
权利人:KOREA KUMHO PETROCHEM CO LTD
摘要:This invention relates to novel carboxylic acid derivatives represented by the following formula I and their synthesis:wherein, R1 is an hydrogen atom, an alkyl group or an alkoxy group of 1 to 20 carbon atoms in a linear, branched or cyclic form; R2 is a carboxy group of 1 to 40 carbon atoms in a linear, branched or cyclic form which is unsubstituted, or substituted into a hydroxy group, an ester group and an ether group.The novel carboxylic acid derivatives are more easily decomposed by acid than t-butyl ester compounds but are not dissolved in basic aqueous solution. According to this invention, carboxylic acid is under condensation with halogen compounds designed to prepare a larger monomolecular compound compared to the conventional method. Further, the condensed site is easily decomposed by acid but is extremely insoluble by basic aqueous solution. The carboxylic acid derivatives in a photoresist composition function not only as a dissolution promoter in the exposed area due to formation of the carboxylic acid, thus enhancement of etching resistance and pattern profile in a resist.

专利号:US-5786448-A
优先权日:1996-11-07
标题:Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein
发明人：NEFZI ADEL; OSTRESH JOHN M; HOUGHTEN RICHARD
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of cyclic urea and cyclic thiourea compounds. The present invention further provides the compounds made by the combinatorial synthesis.

专利号:US-8273403-B2
优先权日:2002-05-10
标题 :Generation of surface coating diversity
发明人：BARDEN MICHAEL C; KAMBOURIS PETER A
权利人:BARDEN MICHAEL C; KAMBOURIS PETER A; BIO LAYER PTY LTD
摘要:This invention relates to a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon which comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a copolymer (B) of at least one passive constituent (P) and at least one active constituent (A); a spacer unit (S) separating the backbone from a functional group; and a functional group (F). The methods comprise the following steps: 1) selecting a plurality of synthons so that each synthon has at least two points of diversity selected from P, A, S and F; 2) applying copolymer B onto a substrate; and 3) attaching a combination of S and F to constituent A of copolymer B. Steps 2) and 3) are performed such that different synthons are generated on localized regions of the substrate.

专利号:US-6809202-B2
优先权日:1996-11-07
标 题 :Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof
发明人：NEFZI ADEL; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring carbonyl gorup and 6-8 atoms in the ring is disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.