专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
参考文献:10.1016/s0031-9422(98)00111-3 摘要:Carballeira NM, Cruz C. 5,9-Nonadecadienoic acids in malvaviscus arboreus and allamanda cathartica. Phytochemistry. 1998 Nov;49(5):1253–6. doi: 10.1016/s0031-9422(98)00111-3. 参考文献:10.1271/bbb.110272 摘要:WATANABE M, IMAI H. Characterization of Glucosylceramides in Leaves of the Grass Family (Poaceae): Pooideae Has Unsaturated Hydroxy Fatty Acids. Bioscience, Biotechnology, and Biochemistry. 2011 Sep 23;75(9):1838–41. doi: 10.1271/bbb.110272. 参考文献:10.1007/978-3-031-89049-9_15 摘要:Chen G, Qian J, Bei Y, Qi Z, Cianciosi D, Armas Diaz Y, Cassotta M, Álvarez-Suárez JM, Battino M, Giampieri F. Chemical Composition of Beeswax. 2025. In: Bee Products – Chemical and Biological Properties.