CAS: 160552-55-6; 4-Amino-1-((2R,3S,5S)-2-(Hydroxymethyl)-3-Oxido-1,3-Oxathiolan-5-yl)Pyrimidin-2(1H)-One
该化合物是一种化学化合物,其特征是其微米丁酮核心结构,其特点是具有碳基和氨基基组的微米胺环,氧化沙拉尼协会的存在表明,它含有五人环,含有硫磺和氧,有助于其潜在的生物活动,该化合物可能由于氢氧甲基和氨-氨基混合组而具有极性特征,可进行氢结合,其立体化学学,以(2R,3S,5S)配置为特征,提出了可能影响其与生物目标相互作用的具体空间安排,该复合物可能对药用化学感兴趣,特别是抗病毒或抗菌剂的研制,因为其结构模型通常与核核素类同有关,此外,其溶解溶液的溶解性和稳定性对于其药物配方的应用十分重要.总体而言,该合成物是一个复杂的结构,具有潜在的治疗影响.
- 英文名称4-Amino-1-((2R,3S,5S)-2-(Hydroxymethyl)-3-Oxido-1,3-Oxathiolan-5-yl)Pyrimidin-2(1H)-One
- 中文名称拉米夫定杂质 G
- IUPAC名称4-amino-1-((2R,3S,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
- 其它别名4-Amino-1-((2R,3S,5S)-2-(Hydroxymethyl)-3-Oxido-1,3-Oxathiolan-5-yl)Pyrimidin-2(1H)-One; Lamivudine Ep Impurity H; Lamivudine Sulfoxide; Lamivudine Impurity 7(Lamivudine Ep Impurity G); Lamivudine Impurit ⅳ:4-Amino-1-((2R,3S,5S)-2-(Hydroxymethyl)-3-Oxido-1,3-Oxathiolan-5-yl)Pyrimidin-2(1H)-One; Lamivudine Ep Imp G; 2(1H)-Pyrimidinone, 4-Amino-1-[(2R,3S,5S)-2-(Hydroxymethyl)-3-Oxido-1,3-Oxathiolan-5-Yl]- (9Ci); Lamivudine (S)-Sulfoxide
- CAS编号160552-55-6
- 分子式:C8H11N3O4S分子量:245.26
- 产品CID: 808094
- 同类组份化合物CAS134678-17-4160552-55-6 (sulfoxide)160552-54-5 (R-sulfoxide)131086-22-1 (±-trans)
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2905310000-1,2-乙二醇
2909110000-乙醚
2930909099-其他有机硫化合物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7122693-B2
优先权日:1988-04-11
标题 :Acetaldehyde acetal compounds, their synthesis, and uses thereof
发明人：BELLEAU EXECUTRIX OF ESTATE PI; DIXIT DILIP M; NGUYEN-BA NGHE
权利人:SHIRE BIOCHEM INC
摘要:The acetaldehyde compounds, 2-thiobenzoylacetaldehyde diethylacetal, 2-benzoyloxyacetaldehyde bis(2-methoxyethyl)acetal, 2-hydroxyacetaldehyde bis( 2-methoxyethyl)acetal, 2-thiobenzoylacetaldehyde bis(2-methoxy-ethyl)acetal, and 2-thioacetaldehyde bis(2-methoxyethyl)acetal, are useful as intermediates in the synthesis of substituted 1,3-oxathiolanes and substituted 1,3-dioxolanes.
专利号:US-2003087918-A1
优先权日:1988-04-11
标题 :Synthesis of substituted 1,3-dioxolanes and substituted 1,3-oxathiolanes with antiviral properties
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主要参考文献
1: Greig SL, Deeks ED. Abacavir/dolutegravir/lamivudine single-tablet regimen: a review of its use in HIV-1 infection. Drugs. 2015 Apr;75(5):503-14. doi: 10.1007/s40265-015-0361-6. Review. Erratum in: Drugs. 2015 Apr;75(5):561. doi: 10.4254/wjh.v7.i6.896. Review.
3: Li H, Zhang HM, Chen LF, Chen YQ, Chen L, Ren H, Hu HD. Prophylactic lamivudine to improve the outcome of HBsAg-positive lymphoma patients during chemotherapy: a systematic review and meta-analysis. Clin Res Hepatol Gastroenterol. 2015 Feb;39(1):80-92. doi: 10.1016/j.clinre.2014.07.010. Epub 2014 Sep 4. Review. Review. doi: 10.1155/2015/971616. Epub 2015 Oct 5. Review.
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