CAS: 1486-51-7; 4-(Benzyloxy)Benzoic Acid

该化合物是一种有机化合物,其特点是芳香结构,包括一种苯并二甲酸混合物,以苯氧基组替代,该化合物一般是白色的脱白晶状固体,在乙醇和丙酮等有机溶剂中溶解,但由于其含水疏水芳香成分,其溶解性有限; 苯基氧化物组的存在增强了其亲脂性,可影响其在不同化学环境中的再活动与互动. 4-(苯并列氧)苯并呋喃可参与各种化学反应,包括酯化和核分裂替代,使其在有机合成中有用,并作为医药和农用化学品生产的一种中间体.此外,其结构特征可能带来具体的生物活动,而这可能对药用化学产生兴趣.适当的处理和储存与许多有机化合物一样,对于确保安全和稳定至关重要.

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CAS号32122-11-5 4-苄氧基苯甲酸甲酯 | CAS号100-39-0 溴化苄 | CAS号99-96-7 4-羟基苯甲酸 | CAS号56442-22-9 间(苯基甲氧基)苯甲酸苯基甲基酯 | CAS号100-44-7 氯化苄 | CAS号56441-55-5 4-(苄氧基)苯甲酸乙酯 | CAS号120-47-8 尼泊金乙酯 | CAS号4397-53-9 4-苄氧基苯甲醛 | CAS号836-43-1 4-苄氧基苄醇 | CAS号123-91-1 1,4-二氧六环 | CAS号111973-84-3 (4-heptylphenyl... | CAS号38713-56-3 4-羟基苯甲酸壬酯 | CAS号1486-49-3 4-苄氧基苯甲酸酐 | CAS号148731-30-0 (4-dodecoxyphen... | CAS号437-64-9 芫花素 | CAS号99-96-7 4-羟基苯甲酸 | CAS号836-43-1 4-苄氧基苄醇 | CAS号54589-41-2 4-苄氧基二苯甲酮 | CAS号127319-86-2 °Ctan-2-yl 4-ph... | CAS号1219-38-1 对羟基苯甲酸正辛酯

合成工艺路线路线简述

    对羟基苯甲酸丙酯置于氢氧化钾,Potassium Carbonate体系中,用 四氢呋喃,乙醇 用作溶剂,化学反应 30.0H,反应生成4-苯甲氧基苯甲酸
    参考文献:1,1'-Disubstituted Ferrocene Containing Hexacatenar Thermotropic Liquid Crystals
    标题:1,1'-Disubstituted Ferrocene Containing Hexacatenar Thermotropic Liquid Crystals
    摘要:本研究介绍了基于烷氧基末端基团的含二茂铁六碳烯金属异构体 4Aâh 的制备和特性,这些烷氧基末端基团包括己氧基 (4A),辛氧基 (4B),癸氧基 (4C),十二氧基 (4D),十四氧基 (4E),十六氧基 (4F),十八氧基 (4G) 和二十四氧基 (4H).引入不同长度的烷基链后,可产生丰富多样的自组装液晶结构.在结晶状态下,含有二茂铁的六碳烯金属异构体 4Aâh 组织成微相分离的单层片状结构.相反,随着链长的变化,金属诱导体结晶熔化后出现了显著的相变:含有六碳烯的二茂铁金属诱导体 4B 和 C 显示出具有 Ia3D 对称性的双连续立方介相,而含有六碳烯的二茂铁金属诱导体 4Dâg 则显示出六方柱状介相.进一步增加烷基链的长度(如 4H 的情况)会抑制液态结晶性,而只产生结晶相.含有二茂铁的金属茂金属分子的这种独特行为可以理解为是由于含有芳香族段的二茂铁的各向异性聚集以及由此产生的与链伸展相关的熵罚.
    Doi:10.1039/b008904O

    海关参考信息

    专利信息


    专利号:US-9453037-B2
    优先权日:2011-07-28
    标 题 :Methylphenidate-prodrugs, processes of making and using the same
    发明人:GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
    权利人:KEMPHARM INC; KEMPHARM INC
    摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

    专利号:US-3975429-A
    优先权日:1973-11-05
    标题:Cyclopropanemethyl esters of cinnamic acid and derivatives thereof
    发明人:HENRICK CLIVE A; STAAL GERARDUS B
    权利人:ZOECON CORP
    摘要:Organic esters and thioesters characterized by the presence of a cyclopropane moiety, synthesis thereof, and compositions thereof for the control of mites and ticks.

    专利号:US-7745490-B2
    优先权日:2004-05-12
    标题 :Substituted N-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies
    发明人:SNOW ALAN D; NGUYEN BETH P; LAKE THOMAS P; CASTILLO GERARDO M; WEIGELE MANFRED
    权利人:PROTEOTECH INC
    摘要:Substituted n-aryl benzamides, related compounds and their pharmaceutically acceptable derivatives, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided.

    专利号:US-8524740-B2
    优先权日:2010-07-15
    标 题 :Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives
    发明人:KUO SHENG-CHU; LEE KUO-HSIUNG; HUANG LI-JIAU; CHOU LI-CHEN; WU TIAN-SHUNG; WAY TZONG-DER; CHUNG JING-GUNG; YANG JAI-SING; HUANG CHI-HUNG; TSAI MENG-TUNG
    权利人:KUO SHENG-CHU; LEE KUO-HSIUNG; HUANG LI-JIAU; CHOU LI-CHEN; WU TIAN-SHUNG; WAY TZONG-DER; CHUNG JING-GUNG; YANG JAI-SING; HUANG CHI-HUNG; TSAI MENG-TUNG; TAIRX INC
    摘要:A compound of Formula I is disclosed as follows: n n n n n n n n n n n n or a pharmaceutically acceptable salt, prodrug, solvate, or metabolite thereof, wherein n R is hydrogen, P(â• O)(OH) 2 , P(â• O)(O(C 1 -C 18 )alkylene(C 6 -C 20 )aryl) 2 , P(â• O)(OH)(OM), P(â• O)(OM) 2 , Pâ• O(O 2 M), S(â• O)(OH) 2 , S(â• O)(O(C 1 -C 18 )alkylene(C 6 -C 20 )aryl) 2 , S(â• O)(OH)(OM), S(â• O)(OM) 2 ; n M is a monovalent or divalent metal ion, or alkylammonium ion; n W is (C 6 -C 20 )aryl, (C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkyl(C 6 -C 20 )aryl, (C 1 -C 18 )alkyl(C 6 -C 20 )heteroaryl, hydroxy(C 6 -C 20 )aryl, hydroxy(C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkoxy(C 6 -C 20 )aryl, (C 1 -C 18 )alkoxy(C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkylenedioxy(C 6 -C 20 )aryl, (C 1 -C 18 )alkylenedioxy(C 6 -C 20 )heteroaryl, halo(C 6 -C 20 )aryl, halo(C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkylamino(C 6 -C 20 )aryl, (C 1 -C 18 )alkylamino(C 6 -C 20 )heteroaryl, (C 1 -C 18 )cycloalkylamino(C 6 -C 20 )aryl, or (C 1 -C 18 )cycloalkylamino(C 6 -C 20 )heteroaryl, and their OR 8 substutes; n R 5 is (C 1 -C 18 alkoxy, hydrogen, hydroxyl, O—(C 1 -C 18 )alkyl(C 6 -C 20 )aryl, halo or OR 8 , or R 5 and R 6 are (C 1 -C 18 )dioxy provided that R 7 is hydrogen; n R 6 is hydroxyl, O—(C 1 -C 18 )alkyl(C 6 -C 20 )aryl, halo or OR 8 , (C 1 -C 18 )alkoxy, (C 1 -C 18 )alkylamino, or (C 1 -C 18 )cycloalkylamino, or R 6 and R 7 are (C 1 -C 18 )dioxy provided that R 5 is hydrogen; n R 7 is hydrogen, halo or OR 8 , hydroxyl, or O—(C 1 -C 18 )alkyl(C 6 -C 20 )aryl; and n R 8 is P(â• O)(OH) 2 , P(â• O)(O(C 1 -C 18 )alkyl(C 6 -C 20 )aryl) 2 , Pâ• O)(OH)(OM), or P(â• O)(OM) 2 , Pâ• O(O 2 M).

    专利号:US-7071145-B2
    优先权日:2001-09-25
    标 题:Thermosensitive recording material, and synthesis method of oligomer composition for the recording material
    发明人:MORITA MITSUNOBU; HAYAKAWA KUNIO; TORII MASAFUMI; NARUSE MITSURU
    权利人:RICOH KK
    摘要:A thermosensitive recording material comprising a thermosensitive layer provided on a substrate, and the thermosensitive layer comprises as main ingredients a leuco dye and a developer to make colored state of said leuco dye when heated, wherein the developer is an oligomer composition obtained from the reaction of a polyvalent isocyanate compound represented by following Formula (I) with an aromatic amine represented by following Formula (II); n nwhere X represents a try- or more-valent group, a represents an integer numeral of 3 or more, b and c represent respectively integer numerals in the range of 0 to 5 and they satisfy a relation of b+c=1 to 5, Z represents hydrogen atom, alkyl group, allyl group or aryl group, and the aryl group may include condensed ling structure thereof, and d represents an integer numeral in the range of 0 to 4. This developer shows excellent reliabilities of both image and background area, and also shows an excellent color-developing characteristics (color developing sensitivity and image density).

    专利号:RU-2195445-C2
    优先权日:1999-05-24
    标 题:Method of synthesis of cis-1-{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)-phenoxy]ethyl}pyrrolidine and intermediate compounds
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    主要参考文献

    [参考文献]: Henryk Marona, Et Al. Preliminary Evaluation Of Anticonvulsant Activity Of Some 4-(Benzyloxy)-Benzamides. Acta Pol Pharm. 2003 Nov-Dec;60(6):477-80.

    合成参考文献


    摘要:Bellanger, C.; Chelli, S.; Lakhdar, S., Science of Synthesis, (2021) , 267.
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