CAS: 121917-57-5; Dizocilpine Maleate

英文名称Dizocilpine Maleate
中文名称(-)-MK-801马来酸盐
IUPAC名称(5R,10S)-5-Methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene maleate
CAS编号121917-57-5
MFCD编号:MFCD00082465
FDA UNII编号:EF13O02IV0
分子式:C20H19NO4
分子量:337.37
产品CID: 306750
同类组份化合物CAS77086-21-6 ((+)_free base)77086-22-7 ((+)-maleate)121917-57-5 ((-)-maleate)
产品分类生物化工 → 抑制剂 → 神经信号通路(Neuronal Signaling)

相似结构搜索
InChIKey: QLTXKCWMEZIHBJ-FWHYOZOBSA-N
1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15…
计算化学: 氢键受体数5.0氢键供体数3.0可旋转键数2.0

物理性质

沸点320.3 °C at 760 mmHg
闪点152.6 °C
PSA:86.63
LogP:3.1911
蒸汽压0.000321mmHg at 25°C
溶解性DMSO: >20 mg/mL
外观形态白色固体
储存条件储存在 -20°C
产品应用该化合物是NMDA受体的非竞争敌者,作为较不活跃的对应物(在行为研究中强度为10倍)比(+)-MK 881 良性.

合成工艺路线路线简述

海关参考信息

2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2912110000-甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-11406709-B2
优先权日:2014-09-15
标题 :Therapeutic and research application of PDCL3
发明人：RAHIMI NADER
权利人:UNIV BOSTON
摘要:Described herein are novel compositions comprising, for example, PDCL3 polypeptides having VEGFR-2 inhibitory activity, inhibitory PDCL3 antibodies and PDCL3-binding fragments thereof, or PDCL3 inhibitory nucleic acid molecules, and methods of their use in anti-angiogenesis and anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, as well as the treatment of those vascular diseases where pathological angiogenesis plays a role, such as in carotid artery disease, macular degeneration, and plaque neovascularization. Also described herein are novel compositions comprising engineered PDCL3 polypeptides having enhanced chaperone activity, recombinant cells comprising such engineered PDCL3 polypeptides having enhanced chaperone activity, and methods thereof for therapeutic protein production and in vitro protein synthesis.

其他信息查阅

山西渊兮生物科技有限公司

电话:15835292188👤
永济市舜都大道北47号

⚠️ 未注册 · 未认证企业

声明: 数据来源：本内容基于各搜索引擎等公开数据整理，仅作展示用。请自行辨别 📄若企业需抹除相关内容或，请联系方我们，我们即刻栓除。

第 1 / 1 页

现货

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

1: Burckhardt A, Rakowsky A, Kahl E, Morchhale S, Mayer D, Panagiotou N, Permien L, Faesel N, Fendt M. Differential effects of orexin system activation on dizocilpine-induced schizophrenia-like behaviors in mice. Neuropeptides. 2026 Apr;116:102587. doi: 10.1016/j.npep.2026.102587. Epub 2026 Jan 28. 26(11):5329. doi: 10.3390/ijms26115329.
3: Konecny J, Misiachna A, Chvojkova M, Kleteckova L, Kolcheva M, Novak M, Prchal L, Ladislav M, Hemelikova K, Netolicky J, Hrabinova M, Kobrlova T, Karasova JZ, Pejchal J, Fibigar J, Vecera Z, Kucera T, Jendelova P, Zahumenska P, Langore E, Doderovic J, Pang YP, Vales K, Korabecny J, Soukup O, Horak M. Dizocilpine derivatives as neuroprotective NMDA receptor antagonists without psychomimetic side effects. Eur J Med Chem. 2024 Dec 15;280:116981. doi: 10.1016/j.ejmech.2024.116981. Epub 2024 Oct 18.
178:117201. doi: 10.1016/j.biopha.2024.117201. Epub 2024 Jul 24.

合成参考文献

参考文献:10.1007/bf00178718
摘要:Hauber W, Münkle M. The adenosine receptor antagonist theophylline induces a monoamine-dependent increase of the anticataleptic effects of NMDA receptor antagonists. Naunyn Schmiedebergs Arch Pharmacol. 1996 Jul;354(2):179–86. doi: 10.1007/bf00178718.
参考文献:10.1007/bf02815206
摘要:Geddes JW, Pang Z, Wiley DH. Hippocampal damage and cytoskeletal disruption resulting from impaired energy metabolism. Implications for Alzheimer disease. Mol Chem Neuropathol. 1996 May;28(1-3):65–74. doi: 10.1007/bf02815206.
参考文献:10.1007/bf00171054
摘要:Molderings GJ, Schmidt K, Bönisch H, Göthert M. Inhibition of 5-HT3 receptor function by imidazolines in mouse neuroblastoma cells: potential involvement of sigma 2 binding sites. Naunyn Schmiedebergs Arch Pharmacol. 1996 Aug;354(3):245–52. doi: 10.1007/bf00171054.
参考文献:10.1007/s00701-003-0209-9
摘要:Caner H, Can A, Atalay B, Erdogan B, Albayrak AH, Kilinc K, Bavbek M, Altinors N. Early effects of mild brain trauma on the cytoskeletal proteins neurofilament160 and MAP2, and the preventive effects of mexilitine. Acta Neurochir (Wien). 2004 Jun;146(6):611–21; discussion 621. doi: 10.1007/s00701-003-0209-9.
参考文献:10.1016/s1734-1140(11)70507-2
摘要:Zhang D, Yang DX, Yang CX, Zhang GW, Gao HR, Zhai Y, Jiao RS, Zhang Y, Zhang H, Liang Y, Xu MY. Effects of norepinephrine on the electrical activities of pain-related neurons in the rat nucleus accumbens. Pharmacol Rep. 2011;63(2):417–22. doi: 10.1016/s1734-1140(11)70507-2.