CAS: 121917-57-5; Dizocilpine Maleate
- 英文名称Dizocilpine Maleate
- 中文名称(-)-MK-801马来酸盐
- IUPAC名称(5R,10S)-5-Methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene maleate
- CAS编号121917-57-5
- MFCD编号:MFCD00082465
- FDA UNII编号:EF13O02IV0
- 分子式:C20H19NO4分子量:337.37
- 产品CID: 306750
- 同类组份化合物CAS77086-21-6 ((+)_free base)77086-22-7 ((+)-maleate)121917-57-5 ((-)-maleate)
- 产品分类生物化工 → 抑制剂 → 神经信号通路(Neuronal Signaling)
物理性质
MSDS等安全信息
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海关参考信息
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2901220000-丙烯
2902600000-乙苯
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专利信息
专利号:US-11406709-B2
优先权日:2014-09-15
标 题 :Therapeutic and research application of PDCL3
发明人：RAHIMI NADER
权利人:UNIV BOSTON
摘要:Described herein are novel compositions comprising, for example, PDCL3 polypeptides having VEGFR-2 inhibitory activity, inhibitory PDCL3 antibodies and PDCL3-binding fragments thereof, or PDCL3 inhibitory nucleic acid molecules, and methods of their use in anti-angiogenesis and anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, as well as the treatment of those vascular diseases where pathological angiogenesis plays a role, such as in carotid artery disease, macular degeneration, and plaque neovascularization. Also described herein are novel compositions comprising engineered PDCL3 polypeptides having enhanced chaperone activity, recombinant cells comprising such engineered PDCL3 polypeptides having enhanced chaperone activity, and methods thereof for therapeutic protein production and in vitro protein synthesis.
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主要参考文献
1: Burckhardt A, Rakowsky A, Kahl E, Morchhale S, Mayer D, Panagiotou N, Permien L, Faesel N, Fendt M. Differential effects of orexin system activation on dizocilpine-induced schizophrenia-like behaviors in mice. Neuropeptides. 2026 Apr;116:102587. doi: 10.1016/j.npep.2026.102587. Epub 2026 Jan 28. 26(11):5329. doi: 10.3390/ijms26115329.
3: Konecny J, Misiachna A, Chvojkova M, Kleteckova L, Kolcheva M, Novak M, Prchal L, Ladislav M, Hemelikova K, Netolicky J, Hrabinova M, Kobrlova T, Karasova JZ, Pejchal J, Fibigar J, Vecera Z, Kucera T, Jendelova P, Zahumenska P, Langore E, Doderovic J, Pang YP, Vales K, Korabecny J, Soukup O, Horak M. Dizocilpine derivatives as neuroprotective NMDA receptor antagonists without psychomimetic side effects. Eur J Med Chem. 2024 Dec 15;280:116981. doi: 10.1016/j.ejmech.2024.116981. Epub 2024 Oct 18.
178:117201. doi: 10.1016/j.biopha.2024.117201. Epub 2024 Jul 24.
合成参考文献
参考文献:10.1007/bf00178718
摘要:Hauber W, Münkle M. The adenosine receptor antagonist theophylline induces a monoamine-dependent increase of the anticataleptic effects of NMDA receptor antagonists. Naunyn Schmiedebergs Arch Pharmacol. 1996 Jul;354(2):179–86. doi: 10.1007/bf00178718.
参考文献:10.1007/bf02815206
摘要:Geddes JW, Pang Z, Wiley DH. Hippocampal damage and cytoskeletal disruption resulting from impaired energy metabolism. Implications for Alzheimer disease. Mol Chem Neuropathol. 1996 May;28(1-3):65–74. doi: 10.1007/bf02815206.
参考文献:10.1007/bf00171054
摘要:Molderings GJ, Schmidt K, Bönisch H, Göthert M. Inhibition of 5-HT3 receptor function by imidazolines in mouse neuroblastoma cells: potential involvement of sigma 2 binding sites. Naunyn Schmiedebergs Arch Pharmacol. 1996 Aug;354(3):245–52. doi: 10.1007/bf00171054.
参考文献:10.1007/s00701-003-0209-9
摘要:Caner H, Can A, Atalay B, Erdogan B, Albayrak AH, Kilinc K, Bavbek M, Altinors N. Early effects of mild brain trauma on the cytoskeletal proteins neurofilament160 and MAP2, and the preventive effects of mexilitine. Acta Neurochir (Wien). 2004 Jun;146(6):611–21; discussion 621. doi: 10.1007/s00701-003-0209-9.
参考文献:10.1016/s1734-1140(11)70507-2
摘要:Zhang D, Yang DX, Yang CX, Zhang GW, Gao HR, Zhai Y, Jiao RS, Zhang Y, Zhang H, Liang Y, Xu MY. Effects of norepinephrine on the electrical activities of pain-related neurons in the rat nucleus accumbens. Pharmacol Rep. 2011;63(2):417–22. doi: 10.1016/s1734-1140(11)70507-2.
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