CAS: 121-60-8; N-Acetylsulfanilyl Chloride

相似化合物

23905-46-6 39169-92-1 31143-71-2

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N-乙酰苯胺置于氯磺酸体系中,用81.6%的收率获得对乙酰胺基苯磺酰氯
参考文献:新型掺有苯并咪唑的磺酰胺类似物的设计,合成和抗菌性评估
标题:新型掺有苯并咪唑的磺酰胺类似物的设计,合成和抗菌性评估
摘要:设计并合成了一系列新的并有苯并咪唑的磺酰胺类似物,以克服不断增加的抗生素耐药性.化合物5C对革兰氏阳性细菌和真菌具有有效的活性,而2,4-二氯苄基衍生物5G对革兰氏阴性细菌具有非常好的活性.这两个活性分子5C和5G都可以有效地插入小牛胸腺dna中,分别形成化合物-Dna复合物,这可能会阻止dna复制,从而发挥其强大的抗菌活性.分子对接实验表明化合物5C和5G可以通过与dna鸟嘌呤形成氢键而插入dna六聚体双链体的碱基对中.这些高活性化合物通过人血清白蛋白(hsa)的运输行为表明,静电相互作用在活性化合物与hsa的强结合中起主要作用,这也被完整的几何计算优化所证实.
Doi:10.1016/j.Ejmech.2017.04.077

专利信息

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:EP-0508725-A1
优先权日:1991-04-09
标题:Novel process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
发明人：WILKENING ROBERT R
权利人:MERCK & CO INC
摘要:A method of synthesizing cyclic iminoethers of the general structural formula These compounds are macrolides, useful as antibiotics and as intermediates in the synthesis of other macrolide antibiotics.

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:EP-0508726-A1
优先权日:1991-04-11
标题:Novel process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives
发明人：WILKENING ROBERT R
权利人:MERCK & CO INC
摘要:A method of synthesizing compounds of the general structural formula Where R is hydrogen, hydroxyl or 1-10 carbon alkyl and n is 0 or 1, and the pharmaceutically acceptable salts thereof. These compounds are macrolides, useful as antibiotics, and also useful as intermediates to the synthesis of other macrolide antibotics.

专利号:US-9422244-B2
优先权日:2010-01-29
标 题 :Synthesis of substituted pyrazoline carboxamidine derivatives
发明人：VAN LOEVEZIJN ARNOLD; LANGE JOSEPHUS H M; BARF GERRIT A; DEN HARTOG ARNOLD P
权利人:VAN LOEVEZIJN ARNOLD; LANGE JOSEPHUS H M; BARF GERRIT A; DEN HARTOG ARNOLD P; ABBVIE BAHAMAS LTD
摘要:This invention relates to organic chemistry, in particular to processes for the preparation of pyrazoline carboxamidine derivatives of formula (I), known as potent 5-HT6 antagonists. The invention also relates to novel intermediates of these compounds. wherein the symbols have the meanings given in the description.

专利号:EP-0515141-A1
优先权日:1991-05-20
标 题:Novel process for the preparation of 8A-aza-8A-homoerythromycin cyclic lactams
发明人：WILKENING ROBERT R
权利人:MERCK & CO INC
摘要:A method of synthesizing cyclic lactams of the general structural formula wherein R is hydrogen or C1-10 alkyl. These compounds are macrolides useful as antibiotics and as intermediates for the synthesis of other macrolide antibiotics.