CAS: 116094-23-6; 29-(2-(15-((1H-Imidazol-4-yl)Methyl)-6-(5-((1H-Imidazol-4-yl)Methyl)-17-Amino-11-(2-Amino-2-Oxoethyl)-8-(3-Amino-3-Oxopropyl)-2-Isobutyl-14-Isopropyl-4,7,10,13,16-Pentaoxo-18-Phenyl-3,6,9,12,15-Pentaazaoctadecanamido)-47-((3-Amino-1-Carboxy-3-Oxopropyl)Carbamoyl)-88-(14-Amino-2-(3-Amino-3-Oxopropyl)-11-(Sec-Butyl)-5-(2-Carboxyethyl)-8-Isopropyl-4,7,10,13-Tetraoxo-3,6,9,12-Tetraazatetradecanamido)-53-(2-Amino-2-Oxoethyl)-62-(3-Amino-3-Oxopropyl)-77-(Sec-Butyl)-24,56-Bis(2-Carboxyethyl)-33,50,65-Tris(4-Hydroxybenzyl)-83-(1-Hydroxyethyl)-12,71,80-Tris(Hydroxymethyl)-18,30,36,59,68-Pentaisobutyl-21,39-Diisopropyl-27-Methyl-7,10,13,16,19,22,25,28,31,34,37,40,49,52,55,58,61,64,67,70,73,76,79,82,85,87-Hexacosaoxo-3,4,44,45,90,91-Hexathia-8,11,14,17,20,23,26,29,32,35,38,41,48,51,54,57,60,63,66,69,72,75,78,81,84,86-Hexacosaazabicyclo[72.11.7]Dononacontane-42-Carboxamido)Acetamido)-5-(4-Aminobutyl)-17,20-Dibenzyl-8-(Carboxymethyl)-26-(3-Guanidinopropyl)-14-(4-Hydroxybenzyl)-2,11-Bis(1-Hydroxyethyl)-4,7,10,13,16,19,22,25,28-Nonaoxo-3,6,9,12,15,18,21,24,27-Nonaazadotriacontanedioic Acid

该化合物是一种对葡萄糖代谢和人体调节至关重要的激素,由51氨基酸组成,分子重量反映其peptide结构.这种特殊变体在B链第28位上具有分酸替代作用,可以影响其生物活动和药用植物.胰岛素主要通过促进将甘蔗吸收进细胞,从而降低血糖水平,在血脂和蛋白新陈代谢中也起到作用.CAS IS 1160(1998)-23-6 确定了这种具体的胰岛素变体,用于治疗用途,特别是糖尿病管理.胰岛素通常通过注射方式进行,因为蛋白质性质使其无法在口服时有效.这种胰岛素变体的稳定性,溶解性和生物利用率对于临床环境的功效至关重要,因此它是生物化学学和药理学的重要对象.

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      专利信息


      专利号:BR-112014026077-B1
      优先权日:2012-04-20
      标 题 :METHOD OF SOLID PHASE SYNTHESIS OF A PROTECTED, PARTIALLY PROTECTED OR UNPROTECTED INSULIN B CHAIN OR AN INSULIN B CHAIN DERIVATIVE, AND METHOD FOR PREPARING AN INSULIN B CHAIN PEPTIDE

      专利号:WO-2013156977-A1
      优先权日:2012-04-20
      标 题 :Solid phase peptide synthesis of insulin using side chain anchored lysine

      专利号:JP-2021505618-A
      优先权日:2017-12-06
      标题:Solid-phase synthesis of NIR fluorescent probe

      专利号:EP-3049068-A1
      优先权日:2013-09-27
      标题 :Synthesis of silk fibroin micro- and submicron spheres using a co-flow method

      专利号:US-2016215103-A1
      优先权日:2013-09-27
      标题 :Synthesis of silk fibroin micro- and submicron spheres using a co-flow method
      发明人：OMENETTO FIORENZO; PEROTTO GIOVANNI; MARELLI BENEDETTO; KAPLAN DAVID; MITROPOULOS ALEXANDER
      权利人:UNIV TUFTS
      摘要:This application relates to silk fibroin particles that are structurally uniform. Related methods are also disclosed.

      专利号:US-2016031962-A1
      优先权日:2012-04-20
      标 题 :Solid phase peptide synthesis of insulin using side chain achored lysine

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      合成参考文献


      参考文献:10.1007/s12630-011-9556-9
      摘要:Forero M, Neira VM, Heikkila AJ, Paul JE. Continuous lumbar transversus abdominis plane block may spread to supraumbilical dermatomes. Journal canadien d'anesthésie. 2011 Jul 12;58(10):948. doi: 10.1007/s12630-011-9556-9.
      摘要:Li YB, Liu J, Liao ZH, Liao Y, Deng WP, Weng JP. [The comparison of insulin aspart and human soluble insulin used in insulin pump therapy in newly diagnosed type 2 diabetic patients]. Zhonghua Yi Xue Za Zhi. 2005 Sep 14;85(35):2472–6.
      参考文献:10.1111/j.1463-1326.2011.01475.x
      摘要:Farmer AJ, Oke J, Stevens R, Holman RR. Differences in insulin treatment satisfaction following randomized addition of biphasic, prandial or basal insulin to oral therapy in type 2 diabetes. Diabetes Obes Metab. 2011 Dec;13(12):1136–41. doi: 10.1111/j.1463-1326.2011.01475.x.
      参考文献:10.1530/eje.1.02021
      摘要:Chen JW, Frystyk J, Lauritzen T, Christiansen JS. Impact of insulin antibodies on insulin aspart pharmacokinetics and pharmacodynamics after 12-week treatment with multiple daily injections of biphasic insulin aspart 30 in patients with type 1 diabetes. Eur J Endocrinol. 2005 Dec;153(6):907–13. doi: 10.1530/eje.1.02021.
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