CAS: 1115-69-1; N-Acetyl-Dl-Alanine

该化合物是一种经化学修改的阿兰ine衍生物,配有与氨氮相连的乙酰组,该化合物通常用于生化研究,丙化物合成,并作为有机化学的土制建筑块,其种族(DL)形式为立体化学研究和酶分辨率实验提供了多种用途.乙酰组增强稳定性和溶解性,使之适合水体和有机介质的应用.N-Acetyl-DL-alaine还被用作研究酶动能学的基质,特别是用于涉及铁球和蛋白质的研究,其定义清晰的结构和再活动使其在制药和精细化学合成中成为有价值的中间体.

结构式图片

相似化合物

19436-52-3 97-69-8 26629-33-4

上下游产品

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合成工艺路线路线简述

    Dl-丙氨酸置于乙酸酐体系中,化学反应生成N-乙酰-Dl-丙氨酸
    参考文献:Substituted Imidazotriazinones
    标题:Substituted Imidazotriazinones
    摘要:本发明涉及新的取代咪唑三嗪酮化合物,其制备方法,以及它们用于生产药物,特别是用于改善感知能力,集中力,学习能力和/或记忆力的用途.

    海关参考信息

    专利信息


    专利号:US-4918222-A
    优先权日:1984-07-27
    标 题 :Process for synthesis of N-acetylglycine
    发明人:LIN JIANG-JEN; KNIFTON JOHN F; YEAKEY ERNEST L
    权利人:TEXACO INC
    摘要:An N-acetylglycine is manufactured by reacting paraformaldehyde with an acetamide and carbon monoxide in the present of a cobalt-containing catalyst promoted by a sulfoxide or dinitride compounds. The presence of sulfoxide or dinitrile ligands are essential for the high yield synthesis of N-acetylglycine and good cobalt recovery.

    专利号:US-4985567-A
    优先权日:1988-03-07
    标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
    发明人:ACHIWA KAZUO; TAKEDA HIDEO
    权利人:KAZUO ACHIWA; FUJI YAKUHIN KOGYO KK
    摘要:New chiral phosphinopyrrolidine compounds of the general formula: ##STR1## wherein R 1 is hydrogen or --COA 1 , --COOA 2 , --CONHA 3 , --SO 2 A 4 or --PO(A 5 ) 2 , A 1 , A 2 , A 3 , A 4 and A 5 each represents independently alkyl or aryl, R 2 is phenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, and R 3 is phenyl, lower-alkylphenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, with the proviso that R 2 and R 3 may not simultaneously by phenyl, p-di(lower-alkyl)-aminophenyl or p-lower-alkoxyphenyl, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

    专利号:US-7230135-B2
    优先权日:2000-12-13
    标 题 :Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts
    发明人:HOGE II GARRETT STEWART; GOEL OM PRAKASH
    权利人:WARNER LAMBERT CO
    摘要:P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.

    专利号:US-5219741-A
    优先权日:1989-09-06
    标题:Method of making L-proline using an N-acyl-L-protine acylase
    发明人:GROEGER ULRICH; LEUCHTENBERGER WOLFGANG; DRAUZ KARLHEINZ
    权利人:DEGUSSA
    摘要:A microbiologically produced, thermostable N-acylproline-acylase and a process for obtaining it from Comamonas testosteroni DSM 5416 and Alcaligenes denitrificans DSM 5417. The enzyme is useful for the synthesis of L-proline from various N-acyl-L-proline derivatives.

    专利号:WO-02083606-A1
    优先权日:2001-04-17
    标 题:A linker system for the synthesis and screening of combinatorial libraries of polyamine derivatives on water compatible supports
    发明人:HALL DENNIS G; WANG FAN
    权利人:UNIV ALBERTA; HALL DENNIS G; WANG FAN
    摘要:The invention is directed to resin-conjugated polyamine combinatorial libraries and methods for making and using them, e.g., methods for screening for polyamine binding molecules in biological samples. The invention provides protected benzophenone-substituted resins, and methods for their synthesis. The invention provides hydroxy-triarylmethane-conjugated resins, and methods for their synthesis. The invention provides chlorotriarylmethane resins, and methods for their synthesis. The invention provides resin-conjugated peptide libraries, and methods for their synthesis.

    专利号:US-2002055124-A1
    优先权日:1998-09-23
    标题:Soluble support for organic synthesis
    发明人:JANDA KIM D; GRAVERT DENNIS J
    权利人:SCRIPPS RESEARCH INST
    摘要:Polymer supports for liquid-phase organic synthesis (LPOS) are employed in a process for transferring a chemical intermediate between immiscilbe solvents. These compounds are produced with an expanded range of solubility range in a variety of solvent systems. A sequence of normal and “livingâ€? free radical polymerizations are employed to generate a library of block copolymers possessing either block or graft architecture with initiators 100, 200 and 3 - 4 and a diverse set of vinyl monomers 5 - 9 . Novel bifunctional initiators are employed that have functional groups that independently produce free radical polymerizations to produce the block copolymers. Preferred functional groups include diazene (—Nâ•?N—) and 2,2,6,6-tetramethylpiperidinyl-1-oxy (TEMPO) moieties tethered by ester or ether linkages.
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    合成参考文献


    参考文献:10.1038/nature10248
    摘要:Hiller DA, Singh V, Zhong M, Strobel SA. A two-step chemical mechanism for ribosome-catalysed peptide bond formation. Nature. 2011 Jul 17;476(7359):236–9.
    参考文献:10.1007/s00726-011-0975-2
    摘要:Danger G, Charlot S, Boiteau L, Pascal R. Activation of carboxyl group with cyanate: peptide bond formation from dicarboxylic acids. Amino Acids. 2012 Jun;42(6):2331–41. doi: 10.1007/s00726-011-0975-2.
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