CAS: 110862-48-1; Atorvastatin

上下游产品

(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester 4-methyl-3-oxo-N-phenylpentanamide benzaldehyde 4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 1-((3R,5R)-3,5-dihydroxy-7-(hydroxyamino)-7-oxoheptyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-7H-pyrrole-3-carboxamide p-Hydroxyatorvastatin o-Hydroxyatorvastatin

专利信息

专利号:WO-2016122325-A1
优先权日:2015-01-30
标 题:Methods for providing intermediates in the synthesis of atorvastatin.
发明人：DÖMLING ALEXANDER STEPHAN SIEGFRIED
权利人:UNIV GRONINGEN
摘要:The invention relates to the field of medicinal chemistry, In particular, it relates to methods for providing intermediates in the synthesis of Atorvastatin, a competitive inhibitor of HMG-Co A reductase. Provided is a process for providing a compound having a Formula (I) or a pharmaceutically acceptable salt, ester, amide or stereoisomer thereof, comprising reacting in a 4 component Ugi-reaction in a single reaction mixture the compounds of formula A, formula B, formula C and formula D.

专利号:US-7339065-B2
优先权日:2003-07-21
标题 :Design and synthesis of optimized ligands for PPAR
发明人：AVERY MITCHELL A; PERSHADSINGH HARRIHAR A
权利人:BETHESDA PHARMACEUTICALS INC; UNIV MISSISSIPPI
摘要:This invention provides new chemical entities useful for treating a variety of clinical disorders including those that are influenced by the activity of peroxisome proliferator activated receptors (PPAR). The structures of the compounds and methods to design, make and use the compounds are provided. Compounds and methods for administering therapeutic compositions comprising the compounds in cases of the disease psoriasis are provided. An exemplary compound having the formula compound is 5adamantan-2-yl-pentanoic acid {2-[4-(2,4-dioxo-thiazolidin-5-yl-methyl)-phenoxy]-ethyl}-methyl-amide is provided.

专利号:CA-2533417-A1
优先权日:2003-07-21
标题 :Design and synthesis of optimized ligands for ppar

专利号:WO-2009040816-A1
优先权日:2007-09-26
标题:Methods of treating lysosomal storage disorders
发明人：HOROWITZ MIA; RON RONEN IDIT
权利人:UNIV RAMOT; HOROWITZ MIA; RON RONEN IDIT
摘要:The sphingolipid storage disease (SLSD) is selected from the group consisting of Gaucher' s Disease, Niemann-Pick Disease, Krabbe' s Disease (Globoid leukodystrophy), Metachromatic leukodystrophy, Ceramide lactoside lipidosis, Fabrys Disease, Tay-Sachs Disease, Sandhoffs Disease and Landing's Disease. The cholesterol synthesis inhibitor is selected from the group consisting of mevastatin, lovastatin, pravastatin, fluvastatin, simvastatin, rosuvastatin, cerivastatin and atorvastatin.

专利号:AU-2004259000-A1
优先权日:2003-07-21
标 题 :Design and synthesis of optimized ligands for PPAR

专利号:WO-02076177-A2
优先权日:2001-03-23
标 题:Design and synthesis of optimized ligands for ppar