专利号:US-9889182-B2 优先权日:2009-09-15 标 题 :Assisted enzyme replacement therapy 发明人:ESKO JEFFREY D; TOR YITZHAK 权利人:ESKO JEFFREY D; TOR YITZHAK; UNIV CALIFORNIA 摘要:Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.
专利号:US-8071535-B2 优先权日:2003-09-12 标 题 :Guanidinium derivatives for improved cellular transport 发明人:TOR YITZHAK; LUEDTKE NATHAN 权利人:TOR YITZHAK; LUEDTKE NATHAN; UNIV CALIFORNIA 摘要:Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.