CAS: 96574-01-5; (R)-3-(3,4-Dihydroxyphenyl)-2-(((E)-3-(2-((E)-3,4-Dihydroxystyryl)-3,4-Dihydroxyphenyl)Acryloyl)Oxy)Propanoic Acid

上下游产品

丹酚酸f (E)-3-(2-((E)-3,4-Dihydroxystyryl)-3,4-Dihydroxyphenyl)Acrylic Acid 158732-59-3
(E)-3-(2-((E)-3,4-Dimethoxystyryl)-3,4-Dimethoxyphenyl)Acrylic Acid 96552-45-3
紫草酸 Lithospermic Acid 28831-65-4
丹酚酸c Salvianolic Acid C 115841-09-3

Sodium Danshensu置于吗啉,4-二甲氨基吡啶,四(三苯基膦)钯,Potassium Carbonate,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺体系中,用 四氢呋喃,二氯甲烷,丙酮 作为反应溶剂,化学反应 56.0H,反应生成 丹酚酸 A
参考文献:由丹参素钠合成(+)-丹酚酸a
标题:由丹参素钠合成(+)-丹酚酸a
摘要:(+)-丹酚酸a是传统中药丹参中活性最高的成分之一,已通过10步合成,总收率为6.5%.从廉价的原香草醛和丹参素钠(在我们的小组中通过不对称催化合成)开始,该过程包括以下内容:Wittig反应可得到具有绝对e-构型的所需产物,Alcl 3脱甲基反应的产率令人满意,以及对烯丙基基团进行实际的脱保护以提供最终产物(+)-丹酚酸a.当前的合成技术具有使用廉价的起始原料,反应条件温和的优势,并且具有用于大规模合成的潜力.
DOI:10.1016/j.Tet.2018.08.044

专利信息

专利号:US-11512075-B2
优先权日:2017-06-14
标 题:Synthesis of 20-nor-salvinorin A
发明人：SHENVI RYAN; ROACH JEREMY; SASANO YUSUKE; BOHN LAURA; SCHMID CULLEN
权利人:SCRIPPS RESEARCH INST
摘要:The invention provides 20-nor-salvinorin A, an analog of the kappa-opioid agonist salvinorin A. The 20-nor-salvinorin A is an active kappa-opioid modulator and can be used for treatment of medical conditions wherein modulation of the kappa-opioid receptor is medically indicated, such as pain, pruritis, depression, or inflammation, or conditions implicating perception and consciousness. 20-nor-salvinorin A can be less additive when used in treatment compared to a mu-opioid receptor agonist, and 20-nor-salvinorin A is more stable in vivo than is parent compound salvinorin A. The invention further provides synthetic intermediates and procedures for preparation of 20-nor-salvinorin A.

专利号:US-8716532-B2
优先权日:2009-03-27
标 题:One pot multicomponent synthesis of some novel hydroxy stilbene derivatives with alpha, beta-carbonyl conjugation under microwave irradiation
发明人：SHARMA ABHISHEK; SINHA ARUN KUMAR; KUMAR RAKESH; SHARMA NAINA
权利人:SHARMA ABHISHEK; SINHA ARUN KUMAR; KUMAR RAKESH; SHARMA NAINA; COUNCIL SCIENT IND RES
摘要:The present invention provides a method for the preparation of some novel multiconjugated 2- or 4-hydroxy substituted stilbenes. The method provides one pot multicomponent approach wherein 3-4 step reaction sequences viz. condensation, decarboxylation and Heck coupling occur simultaneously which results in an enhanced yield of desired products and reduced reaction times.

专利号:US-2012165567-A1
优先权日:2009-03-27
标 题 :One pot multicomponent synthesis of some novel hydroxy stilbene derivatives with alpha, beta-carbonyl conjugation under microwave irradiation

专利号:CN-115197851-A
优先权日:2022-05-30
标题:Penicillium difficile and its use in regulating the synthesis of tanshinones in the roots of Salvia miltiorrhiza

专利号:CN-115197851-B
优先权日:2022-05-30
标题 :Penicillium rugosa and its use in regulating the synthesis of tanshinone components in the root of Danshen

专利号:US-8507463-B2
优先权日:2005-06-13
标题 :Nucleotide analogue prodrug and the preparation thereof
发明人：YUAN JIANDONG
权利人:YUAN JIANDONG; JIANGSU CHIA TAI TIANQING PHAR; BRIGHTGENE BIO MEDICAL TECHNOLOGY CO LTD
摘要:The present invention provides: 1) Derivative solid form of 9-[2-(R)-[bis[pivaloyloxymethoxy]-phosphinylmethoxy]propyl]adenine (bis-POM PMPA, abbreviated as TD hereinafter), including crystalline form A and form B of TD, TD fumarate salts and cyclodextrin inclusion complex of TD; 2) Synthesis and purification methods of TD and Solidification method of TD oil, including converting TD oil to crystalline TD in Form A and Form B, solid TD salts and cyclodextrin inclusion complex of TD; 3) Stable pharmaceutical compositions containing TD derivatives and their preparation; 4) The use of the above TD derivatives in the antiviral treatments, especially in the treatment of HIV, HBV, CMV, HSV-1, HSV-2 and human Herpes virus infections.