CAS: 903513-58-6; 4-Bromo-2,6-Difluoropyridine

相似化合物

128071-98-7 1513-65-1 766-11-0

上下游产品

CAS号401816-16-8 2,6-二氟吡啶-4-硼酸

📜2,6-二氟吡啶-4-硼酸频哪醇酯置于copper(Ll) Bromide体系中,用 甲醇,水 作为反应溶剂,化学反应 1.5H,反应生成 2,6-二氟-4-溴吡啶
参考文献: Process For Preparing 1-[(3R,4S)-4-Cyanotetrahydropyran-3-Yl]-3-[(2-Fluoro-6-Methoxy-4-Pyridyl)Amino]P Yrazole-4-Carboxamide[fr] Procédé De Préparation De 1-[(3R,4S)-4-Cyanotétrahydropyran-3-Yl]-3-[(2-Fluoro-6-Méthoxy-4-Pyridyl)Amino]Pyrazole-4-Carboxamide
标题: Process For Preparing 1-[(3R,4S)-4-Cyanotetrahydropyran-3-Yl]-3-[(2-Fluoro-6-Methoxy-4-Pyridyl)Amino]P Yrazole-4-Carboxamide[fr] Procédé De Préparation De 1-[(3R,4S)-4-Cyanotétrahydropyran-3-Yl]-3-[(2-Fluoro-6-Méthoxy-4-Pyridyl)Amino]Pyrazole-4-Carboxamide
摘要:该申请涉及制备1-[(3R,4S)-4-氰基四氢吡喃-3-基]-3-[(2-氟-6-甲氧基-4-吡啶基)氨基]吡唑-4-甲酰胺(i)的过程,包括(i)溴和碘吡啶中间体的合成,(II)可以以对映纯形式获得的吡唑酯中间体的合成,以及(iii)将这些中间体组合成化合物(i).

专利信息

专利号:WO-2020118597-A1
优先权日:2018-12-13
标 题 :Process for making 1- [ (3r, 4s) -4-cyanotetrahydropyran-3-yl] -3- [ (2-fluoro-6-methoxy-4-pyridyl) amino] pyrazole-4-carboxamide
发明人：CHASSAING CHRISTOPHE PIERRE ALAIN; YIN JINGJUN; CLEATOR EDWARD; SONG LICHEN; XIAO WENSONG; DAHMEN THOMAS; SALANTA DANIEL; SCHEIPERS CLAUDIA; SCHMITT HARALD
权利人:INTERVET INT BV; INTERVET INC; CHASSAING CHRISTOPHE PIERRE ALAIN; YIN JINGJUN; CLEATOR EDWARD; SONG LICHEN; XIAO WENSONG; DAHMEN THOMAS; SALANTA DANIEL; SCHEIPERS CLAUDIA; SCHMITT HARALD
摘要:New processes for the preparation of 1- [ (3R, 4S) -4-cyanotetrahydropyran-3-yl] -3- [ (2-fluoro-6-methoxy-4-pyridyl) amino] pyrazole-4-carboxamide (I) which include (i) novel more efficient synthesis for bromo and iodo pyridine intermediates, (ii) synthesis of a novel pyrazole ester intermediate which can be obtained in enantiopure form and (iii) the combination of these intermediates into compound (I).

专利号:US-7485725-B1
优先权日:2004-11-12
标 题:Substituted pyridines
发明人：CEFALO DUSTIN R; HENDERSON JASON I; MOKRI HOMAYOUN H
权利人:FRONTIER SCIENT INC
摘要:A class of 2,4-; 2,3,4-; 2,4,6-; 2,3,4,5,6-substituted pyridines is provided which include novel compounds. The substitutions are achieved according to methods disclosed herein in which a metallated pyridine is reacted with an electrophile. Suitable electrophiles include CO 2 , SO 2 , dialkylcarbonates, ureas, formamides, amides, carboxylic acid esters, mono- and dihaloalkyls, halogens such as chlorine, fluorine, bromine, and iodine, metallic salts, sulfones, sulfonyls, aldehydes, ketones, anhydrides, nitriles, and electrophilic boron compounds including, but not limited to, boron trialkoxides and boron trihalides. The subject invention more specifically discloses a process for the synthesis of 2,6-difluoropyridin-4-ylboronic acid which comprises: (1) reacting 2,4,6-trifluoropyridine with hydrazine monohydrate to produce 2,6-difluoro-4-hydrazinopyridine, (2) reacting the 2,6-difluoro-4-hydrazinopyridine with elemental bromine to produce 4-bromo-2,6-difluoropyridine, and (3) reacting the 4-bromo-2,6-difluoropyridine with an organolithium compound and a borate at a temperature of less than 0° C. to produce the 2,6-difluoropyridin-4-ylboronic acid, wherein said process is conducted in an organic solvent.

专利号:US-7087755-B1
优先权日:2004-11-12
标 题 :Substituted pyridines
发明人：CEFALO DUSTIN R; HENDERSON JASON I; MOKRI HOMAYOUN H
权利人:FRONTIER SCIENT INC
摘要:A class of 2,4-; 2,3,4-; 2,4,6-; 2,3,4,5,6-substituted pyridines is provided which include novel compounds. The substitutions are achieved according to methods disclosed herein in which a metallated pyridine is reacted with an electrophile. Suitable electrophiles include CO 2 , SO 2 , dialkylcarbonates, ureas, formamides, amides, carboxylic acid esters, mono- and dihaloalkyls, halogens such as chlorine, fluorine, bromine, and iodine, metallic salts, sulfones, sulfonyls, aldehydes, ketones, anhydrides, nitrites, and electrophilic boron compounds including, but not limited to, boron trialkoxides and boron trihalides. The subject invention more specifically discloses a process for the synthesis of 2,6-difluoropyridin-4-ylboronic acid which comprises: (1) reacting 2,4,6-trifluoropyridine with hydrazine monohydrate to produce 2,6-difluoro-4-hydrazinopyridine, (2) reacting the 2,6-difluoro-4-hydrazinopyridine with elemental bromine to produce 4-bromo-2,6-difluoropyridine, and (3) reacting the 4-bromo-2,6-difluoropyridine with an organolithium compound and a borate at a temperature of less than about 0° C. to produce the 2,6-difluoropyridin-4-ylboronic acid, wherein said process is conducted in an organic solvent.