CAS: 877-88-3; 1-(Bromomethyl)-3,5-Dimethoxybenzene

该化合物是一种有机化合物,其特点是其芳香结构,其特点是在3和5位置上用两种甲氧基组和溴甲基组替换一个苯环,该化合物一般是淡黄色液体或固体的无色物质,视其纯度和温度而定;由于溴原子的存在,它具有可参与核生殖替代反应的反光作用而闻名于此;甲基氧组增强芳香环的电子密度,使其对电极更具反应力.3,5-二甲基氧苯基溴经常被用作有机合成的中间体,特别是在各种药品和农用化学剂的制作过程中;必须谨慎地处理这一化合物,因为如果吸入或摄入,可能会对健康造成危害,而且在其使用和储存过程中应采取适当的安全措施.此外,它可溶于有机溶剂,便于其在各种化学反应中应用.

英文名称1-(Bromomethyl)-3,5-Dimethoxybenzene
中文名称3,5-二甲氧基苄溴
IUPAC名称1-(bromomethyl)-3,5-dimethoxybenzene
其它别名α-溴-3,5-二甲氧基甲苯; 35二甲氧基苄溴; α-Bromo-3,5-Dimethoxytoluene; 1-(Bromomethyl)-3,5-Dimethoxybenzene
CAS编号877-88-3
MFCD编号:MFCD01321368
EINECS号:618-071-7
分子式:C9H11BrO2
分子量:231.09
产品CID: 1886528
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: BTHIGJGJAPYFSJ-UHFFFAOYSA-N
InChI=1S/C9H11BrO2/c1-11-8-3-7(6-10)4-9(5-8)12-2/h3-5H,6H2,1-2H3…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数3.0

MSDS等安全信息

GHS象形图
GHS符号GHS05;
注释: Corrosion
危险类别皮肤腐蚀类别1B
严重眼损伤类别1
金属腐蚀物类别1
警示词Danger(危险)
危险描述H314 |造成严重皮肤灼伤和眼损伤.
H318 |造成严重眼损伤.
H290 |可能对金属造成腐蚀.
防范说明P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
危险等级8
UN编号3261.0
危险品标志C
包装等级Ⅱ
安全声明26-27-36/37/39-45
危险类别码34
WGK Germany3.0

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

合成目标产物 3,5-Dimethoxybenzyl Bromide 主要起始原料 3,5-Dimethoxybenzyl Alcohol
705-76-0 = 877-88-3
反应条件:1.1 Reagents: Phosphorus Tribromide Solvents: 1,4-Dioxane; 1 H,40 °C; 40 °C -> Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water; Rt
标题:Studies Toward The Synthesis Of Caramboxin Analogues
作者:Filho,Ronaldo E. Oliveira; Higa,Vanessa M.; Omori,Alvaro T.
参考文献:Journal Of The Brazilian Chemical Society 日期:2019 卷标:30(3) 页码:528-540]

705-76-0 = 877-88-3
反应条件:1.1 Reagents: Triphenylphosphine Solvents: Dichloromethane; 10 Min,Rt1.2 Reagents: Carbon Tetrabromide; -78 °C; 80 Min,-50 °C
标题:Synthesis And Biological Evaluation Of Bilobol And Adipostatin A
作者:Tanaka,Ayano; Arai,Yasuhiro; Kim,Su-Nam; Ham,Jungyeob; Usuki,Toyonobu
参考文献:Journal Of Asian Natural Products Research 日期:2011 卷标:13(4) 页码:290-296]

705-76-0 = 877-88-3
反应条件:1.1 Reagents: Pyridine,Phosphorus Tribromide Solvents: Dichloromethane; 0 °C; 4 H,0 °C -> Rt1.2 Solvents: Water; Cooled
标题:Design,Synthesis,And Evaluation Of Resveratrol Derivatives As Ass1-42 Aggregation Inhibitors,Antioxidants,And Neuroprotective Agents
作者:Lu,Chuanjun; Guo,Yueyan; Li,Jianheng; Yao,Meicun; Liao,Qiongfeng; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2012 卷标:22(24) 页码:7683-7687]

705-76-0 + 2857-97-8 = 877-88-3 [标题:Reaction Conditions
标题:Synthesis Of Nonadeutero Olivetol And Nonadeutero Cannabinoids
作者:Seltzman,Herbert H.; Begum,Mosammat K.; Wyrick,Christopher D.
参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:1991 卷标:29(9) 页码:1009-18]

705-76-0 = 877-88-3
反应条件:1.1 Reagents: Phosphorus Tribromide Solvents: Dichloromethane; 0 °C; 2 H,0 °C; 0 °C -> Rt; 1 H,Rt1.2 Solvents: Water; 0 °C; 0 °C -> Rt
标题:Simple And High-Efficiency Method For Synthesis Of Trans-Resveratrol
参考文献:China]

705-76-0 = 877-88-3
反应条件:1.1 Reagents: Phosphorus Tribromide Solvents: Dichloromethane; 2 H,Rt
标题:Synthesis Of Cannabinol By A Modified Ullmann-Ziegler Cross-Coupling
作者:Nuellen,Max P.; Goettlich,Richard
参考文献:Synlett 日期:2013 卷标:24(9) 页码:1109-1112]

705-76-0 = 877-88-3
反应条件:1.1 Reagents: Pyridine,Phosphorus Tribromide Solvents: Diethyl Ether; 25 °C; 3 H,40 °C
标题:Total Synthesis Of Resveratrol-Based Natural Products: A Chemoselective Solution
作者:Snyder,Scott A.; Zografos,Alexandros L.; Lin,Yunqing
参考文献:Angewandte Chemie 日期:2007 卷标:46(43) 页码:8186-8191]

705-76-0 = 877-88-3
反应条件:1.1 Reagents: Phosphorus Tribromide Solvents: Dichloromethane; Cooled; 4.5 H,Rt1.2 Reagents: Water; Cooled
标题:Synthesis And Hiv-1 Inhibitory Activity Of Natural Products Isolated From Gnetum Parvifolium And Their Analogues
作者:Piao,Zhisong; Feng,Yabing; Wang,Lin; Zhang,Xingquan; Lin,Mao
参考文献:Yaoxue Xuebao 日期:2010 卷标:45(12) 页码:1509-1515]

705-76-0 = 877-88-3
反应条件:1.1 Reagents: Phosphorus Tribromide Solvents: Diethyl Ether; 0 °C; 30 Min,0 °C1.2 Reagents: Potassium Bromide Solvents: Water; 0 °C
标题:Synthesis And Biological Evaluation Of Novel Resveratrol-Oxadiazole Hybrid Heterocycles As Potential Antiproliferative Agents
作者:Murty,M. S. R.; Penthala,Raju; Polepalli,Sowjanya; Jain,N.
参考文献:Medicinal Chemistry Research 日期:2016 卷标:25(4) 页码:627-643]

705-76-0 = 877-88-3
反应条件:1.1 Reagents: Pyridine,Phosphorus Tribromide Solvents: Dichloromethane; 0 °C; 0 °C -> Rt; 4 H,Rt1.2 Reagents: Water; Cooled
标题:Multitarget-Directed Resveratrol Derivatives: Anti-Cholinesterases,Anti-β-Amyloid Aggregation And Monoamine Oxidase Inhibition Properties Against Alzheimer'S Disease
作者:Pan,Long-Fei; Wang,Xiao-Bing; Xie,Sai-Sai; Li,Su-Yi; Kong,Ling-Yi
参考文献:Medchemcomm 日期:2014 卷标:5(5) 页码:609-616]

705-76-0 = 877-88-3
反应条件:1.1 Reagents: Phosphorus Tribromide Solvents: Dichloromethane; 0 °C; 4 H,Rt
标题:Design,Synthesis And Antiproliferative Activity Of The New Conjugates Of E7010 And Resveratrol As Tubulin Polymerization Inhibitors
作者:Kamal,Ahmed; Ashraf,Md.; Basha,Shaik Thokhir; Ali Hussaini,S. M.; Singh,Shamshair; Et Al
参考文献:Organic & Biomolecular Chemistry 日期:2016 卷标:14(4) 页码:1382-1394]

705-76-0 = 877-88-3
反应条件:1.1 Reagents: Pyridine,Phosphorus Tribromide Solvents: Diethyl Ether; 25 °C; 3 H,40 °C1.2 Reagents: Water; Cooled
标题:Total Synthesis Of Diverse Carbogenic Complexity Within The Resveratrol Class From A Common Building Block
作者:Snyder,Scott A.; Breazzano,Steven P.; Ross,Audrey G.; Lin,Yunqing; Zografos,Alexandros L.
参考文献:Journal Of The American Chemical Society 日期:2009 卷标:131(5) 页码:1753-1765]

705-76-0 = 877-88-3
反应条件:1.1 Reagents: Phosphorus Tribromide Solvents: Dichloromethane
标题:A Convenient Synthesis Of 14C-Labeled Resveratrol
作者:Zeng,Dongli; Mi,Qixi; Sun,Hongfang; Wang,Haifang
参考文献:Journal Of Labelled Compounds & Radiopharmaceuticals 日期:2004 卷标:47(3) 页码:167-174]

7311-34-4 = 877-88-3
反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol; 1 - 3 H,0 °C1.2 Reagents: Sulfuric Acid Solvents: Water; Acidified1.3 Reagents: Phosphorus Tribromide Solvents: Diethyl Ether; 3 - 12 H,0 °C1.4 Reagents: Water
标题:New Potential Mammalian Lignan Metabolites Of Environmental Phytoestrogens
作者:Raffaelli,Barbara; Leppala,Eija; Chappuis,Clement; Wahala,Kristiina
参考文献:Environmental Chemistry Letters 日期:2006 卷标:4(1) 页码:1-9

3,5-二甲氧基苯甲醛置于吡啶,Sodium Tetrahydroborate,三溴化磷体系中,用甲醇作为反应溶剂,化学反应生成 3,5-二甲氧基溴苄
参考文献:Synthesis And Biological Evaluation Of Novel Gigantol Derivatives As Potential Agents In Prevention Of Diabetic Cataract
标题:Synthesis And Biological Evaluation Of Novel Gigantol Derivatives As Potential Agents In Prevention Of Diabetic Cataract
摘要:作为我们致力于开发天然抗糖尿病性白内障药物的延续,从石斛中分离出巨花素,并发现它能抑制醛糖还原酶(ar)和诱导型一氧化氮合酶(inos)的活性,这两种酶在糖尿病性白内障的发展和进展中起着重要作用.为了提高其生物效力和便于作为治疗剂使用,设计并合成了巨花素(化合物14F)及一系列新衍生物.这些衍生物在苯环上有不同的取代基(化合物4,5,8,14A-E),用具有更大立体障碍的环替代苯环(化合物10,17C),或修改碳链(化合物17A,17B,21,23,25).所有衍生物在体外对ar和inos的活性以及在d-半乳糖诱导的人晶状体上皮细胞凋亡中的作用进行了测试.化合物5,10,14A,14B,14D,14E,14F,17B,17C,23和25抑制了ar的活性,Ic50值范围为5.02至288.8 μm.化合物5,10,14B和14F抑制了inos的活性,Ic50范围为432.6至1188.7 μm.化合物5,8,10,14B,14F和17C保护细胞免受d-半乳糖诱导的凋亡,存活率范围为55.2至76.26%.在巨花素及其衍生物中,化合物10显示出最大的生物效力,值得开发为糖尿病性白内障的治疗剂.
DOI:10.1371/journal.Pone.0141092

海关参考信息

2902300000-甲苯
2905110000-甲醇
2907221000-对苯二酚
2903399020-溴甲烷
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-7189864-B2
优先权日:1990-11-19
标题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-6022996-A
优先权日:1990-11-19
标题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:EP-0641333-B1
优先权日:1992-05-20
标题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO; MONSANTO CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R<1> is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR<9> or SR<9>, where R<9> represents hydrogen or alkyl; and P<1> and P<2> independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.

专利号:EP-0855388-B1
优先权日:1993-11-23
标题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P; FRESKOS JOHN J; DECRESCENZO GARY A; BERTENSHAW DEBORAH E; HEINTZ ROBERT M; ZHANG SUHONG; LIU CHIN; LANEMAN SCOTT A
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a cyanohydrin from a chiral alpha amino aldehyde.

专利号:US-10188136-B2
优先权日:2016-02-16
标题:Hydrophobin mimics: process for preparation thereof
发明人：BRITTO Sandanaraj Selvaraj; REDDY Mullapudi Mohan; BHANDARI PAVANKUMAR JANARDHAN; RAO KASULADEVU JAGANNADHA
权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES
摘要:The present invention discloses hydrophobin mimics of formula (I) comprising a protein head group, hydrophilic linker and hydrophobic tail and to a process for synthesis of library of hydrophobin mimics thereof. The hydrophobin mimics of the present invention self-assemble to form protein nanoparticles/nanocontainer either alone or in a specified chemical environment. The hydrophobin mimics (I) of the present invention find application in area of bio-nanotechnology.

专利号:US-5633357-A
优先权日:1991-11-27
标题 :Synthesis of carboxylic acid glucuronides
发明人：TIUS MARCUS A; HAGADONE MARK R
权利人:SYNTHETIC TECHNOLOGY CORP
摘要:A method of producing a carboxylic acid glucuronide by reacting a carboxylic acid precursor with a blocked sugar epoxide precursor is disclosed. Also disclosed are: deuterated 11-nor-Î” 8 - or Î” 9 -THC carboxylic acid glucuronide having a deuterated hydrocarbon chain; 5'-deuterated 11-nor-Î” 8 - or Î” 9 -THC-carboxylic acid or 5'-deuterated Î” 8 - or Î” 9 -THC glucuronide. The compositions are useful as GC-MS standards; in methods for preparing antibodies reactive with a THC glucuronide; and, in GC-MS diagnostic methods for THC metabolites.