CAS: 874-84-0; 2-(2-Nitrovinyl)Thiophene

上下游产品

CAS号98-03-3 2-噻吩甲醛 | CAS号75-52-5 硝基甲烷 | CAS号13533-27-2 4-甲氧基-n-(2-噻吩亚甲基)苯胺 | CAS号30807-46-6 2-(2-nitroethyl... | CAS号15509-95-2 1,3,5-三(2-噻吩基)苯 | CAS号30433-91-1 2-噻吩乙胺 | CAS号1088706-75-5 (Z)-2-(2-(pheny... | CAS号123432-00-8 2-(2-phenylsulf... | CAS号1119523-16-8 3-氨基-4-硝基-5-(噻吩... | CAS号51626-50-7 2-(1H-吲哚-3-基)-2...

📜2-噻吩甲醛,硝基甲烷置于sodium Hydroxide体系中,用 甲醇,水 作为反应溶剂,化学反应 5.0H,反应生成 2-硝基乙烯基噻吩
参考文献:通过苯胺的有机催化不对称亲电胺化动力学拆分 1,2-二胺
标题:通过苯胺的有机催化不对称亲电胺化动力学拆分 1,2-二胺
摘要:1,2-二胺的有效动力学拆分 (Kr) 协议已通过手性磷酸催化实现的苯胺不对称亲电胺化开发.多种取代的 1,2-二胺与该方法兼容,可反应生成具有高对映选择性(s因子高达 218)的回收起始材料和胺化产物.值得注意的是,该方法适用于带有 α-叔胺部分的 1,2-二胺的动力学拆分,这代表了此类 1,2-二胺的第一个 Kr.引入的肼基团的轻松去除和n-芳基的氧化裂解以释放游离伯胺证明了该方法的价值.
DOI:10.1002/cjoc.202200125

专利信息

专利号:EP-0439404-B1
优先权日:1990-01-25
标题 :Preparation of 2-(2'-thienyl) alkylamines and derivatives thereof and synthesis of 4,5,6,7- thieno [3,2-c] pyridine derivatives therefrom
发明人：KHATRI HIRALAL N; DEHOFF BRADLEY S
权利人:SANOFI SA
摘要:An improved process for the synthesis of 2-(2 min -thienyl)ethylamine from suitably functionalized derivatives of 2-(2 min -thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2 min -thienyl)ethylamine produced by this process is advantageously converted to the carbamic acid salt, which is suitably reconverted to 2-(2 min -thienyl)ethylamine, a useful intermediate in the synthesis of ticlopidine.

专利号:US-5068360-A
优先权日:1990-01-25
标题 :Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno(3,2-C)pyridine derivatives therefrom
发明人：DEHOFF BRADLEY S
权利人:SYNTEX INC
摘要:An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:US-5191090-A
优先权日:1990-01-25
标题:Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno[3,2-c]pyridine derivatives therefrom
发明人：DEHOFF BRADLEY S
权利人:SYNTEX INC
摘要:An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:US-8071782-B2
优先权日:2007-10-02
标 题 :Synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles
发明人：DENG XIAOHU; MANI NEELAKANDHA S
权利人:DENG XIAOHU; MANI NEELAKANDHA S; JANSSEN PHARMACEUTICA NV
摘要:This invention concerns the synthesis of highly substituted pyrazoles, which are structural components of pharmacological compounds, through reaction of hydrazones with nitroolefins.

专利号:US-4906756-A
优先权日:1988-05-10
标 题 :2-(2-nitrovinyl)thiophene reduction and synthesis of thieno[3,2-c]pyridine derivatives
发明人：LODEWIJK ERIC; KHATRI HIRALAL N
权利人:SYNTEX INC
摘要:An improved process for the reduction of 2-(2-nitrovinyl)thiophene to form 2-(2-thienyl)ethylamine employs a boron-containing reducing agent, preferably diborane. The 2-(2-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:US-5516910-A
优先权日:1991-01-31
标题:N--2--chlorobenzyl--2--oxo and n--2--chlorobenzyl--2,2--dioxo--1,2,3--oxathiazolidine derivatives, their preparation and synthesis of thieno[3,2--c]pyridine derivatives therefrom
发明人：COOPER GARY F; MCCARTHY KEITH E
权利人:SYNTEX INC
摘要:Compounds of the formula: ##STR1## wherein: A is oxo or dioxo; n R 1 , R 2 and R 3 are independently hydrogen or lower alkyl of one to six carbon atoms; n R 4 , R 5 , R 6 and R 7 are independently hydrogen, lower alkyl of one to six carbon atoms, alkoxy, acyl or halo; n are advantageously converted to thieno[3,2-c]pyridine derivatives and the pharmaceutically acceptable salts thereof, particularly ticlopidine hydrochloride.