CAS: 873331-73-8; 5-Bromo-2-Ethylpyrimidine
该化合物是一种七环有机化合物,其特征是六人环,含有1号阵地和3号据点的两个氮原子,这是火命衍生物的典型特征;5号据点和2号据点的乙基组有溴原子,其独特的化学特性是乙基原子的存在;该化合物可能由于电阴性溴原子而呈现中度极性,该物质会影响该物质在各种溶剂中的再活性和溶解性;由于该化合物的生物活动,包括可能用于制药业的用途,因此对医药化学产生兴趣.该化合物可能参与各种化学反应,例如核糖分泌替代物或电荷芳香替代物,因为存在溴分成分,该化合物的结构允许与生物目标发生潜在互动,从而有可能在药物开发方面进行进一步研究.应当注意到安全和处理预防措施,因为许多卤化化合物具有潜在的毒性和环境影响.
相似化合物
7752-78-5 831203-15-7 1060813-04-8物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号1235450-86-8 5-溴-2-乙基-4-嘧啶羧酸 | CAS号557-20-0 二乙基锌 | CAS号32779-36-5 5-溴-2-氯嘧啶合成工艺路线路线简述
- 32779-36-5 = 873331-73-8
反应条件:1.1 Catalysts: Palladium Chloride,1,1-Bis(Diphenylphosphino)Ferrocene Solvents: Hexane,1,4-Dioxane; Overnight,50 °C
标题:A Simple Cu-Catalyzed Coupling Approach To Substituted 3-Pyridinol And 5-Pyrimidinol Antioxidants
作者:Nara,Susheel J.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2008 卷标:73(23) 页码:9326-9333]
7752-82-1 = 873331-73-8
反应条件:1.1 Reagents: Benzyltriethylammonium Chloride,Tert-Butyl Nitrite Solvents: Dichloromethane; 1 - 12 H,Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water; Rt2.1 Catalysts: Palladium Chloride,1,1-Bis(Diphenylphosphino)Ferrocene Solvents: Hexane,1,4-Dioxane; Overnight,50 °C
标题:A Simple Cu-Catalyzed Coupling Approach To Substituted 3-Pyridinol And 5-Pyrimidinol Antioxidants
作者:Nara,Susheel J.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2008 卷标:73(23) 页码:9326-9333]
109-12-6 = 873331-73-8
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 0 °C; Overnight,Rt2.1 Reagents: Benzyltriethylammonium Chloride,Tert-Butyl Nitrite Solvents: Dichloromethane; 1 - 12 H,Rt2.2 Reagents: Sodium Bicarbonate Solvents: Water; Rt3.1 Catalysts: Palladium Chloride,1,1-Bis(Diphenylphosphino)Ferrocene Solvents: Hexane,1,4-Dioxane; Overnight,50 °C
标题:A Simple Cu-Catalyzed Coupling Approach To Substituted 3-Pyridinol And 5-Pyrimidinol Antioxidants
作者:Nara,Susheel J.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2008 卷标:73(23) 页码:9326-9333
📜5-溴-2-乙基-4-嘧啶羧酸置于petroleum Ether,乙酸乙酯体系中,用 邻二甲苯 作为反应溶剂,化学反应 2.0H,以ethyl Acetate In Petroleum Ether (5%) To Give Compound 0601-121 (1.7 G,38%) As A Yellow Liquid的收率获得产物5-溴-2-乙基嘧啶
参考文献:Treatment Of Cancers Having K-Ras Mutations
标题:Treatment Of Cancers Having K-Ras Mutations
摘要:本发明提供了一种治疗与k-Ras突变相关的癌症的方法,适用于需要该方法的患者.该方法包括以下步骤:(1)鉴定患有与k-Ras突变相关的癌症的患者;以及(2)向患者施用(i)pi3激酶抑制剂和(II)hdac抑制剂,其中pi3激酶抑制剂和hdac抑制剂的剂量合起来具有治疗效果.
海关参考信息
- 2901100000-饱和无环烃
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专利信息
专利号:US-2024376065-A1
优先权日:2021-07-29
标 题:Thionolactones, processes of synthesis, uses as comonomers and for polymer functionalization and degradation
发明人：DUFILS PIERRE-EMMANUEL; PLUMMER CHRISTOPHER MARK; WILSON DAVID JAMES; GIGMES DIDIER; GUILLANEUF YOHANN
权利人:SPECIALTY OPERATIONS FRANCE; UNIV AIX MARSEILLE; CENTRE NAT RECH SCIENT
摘要:The instant invention relates to thionolactone compounds useful as comonomers to introduce weak bonds for polymer degradation or functionalization. The invention is also directed to processes for the preparation of said compounds, notably by thionation of the corresponding lactones. The invention is furthermore directed to uses of said thionolactones as comonomers, copolymers made from these comonomers, and processes for the preparation of said copolymers.
专利号:WO-0226909-A1
优先权日:2000-09-29
标 题 :Compositions and methods for thionation during chemical synthesis reactions
发明人：CURPHEY THOMAS J
权利人:DARTMOUTH COLLEGE; CURPHEY THOMAS J
摘要:Compositions and methods for using these compositions to produce high yields of thionated compounds are provided.
专利号:US-7012148-B2
优先权日:2001-09-25
标题 :Compositions and methods for thionation during chemical synthesis reactions
发明人：CURPHEY THOMAS J
权利人:DARTMOUTH COLLEGE
摘要:Compositions and methods for using these compositions to produce high yields of thionated compounds are provided.
专利号:EP-4377303-A1
优先权日:2021-07-29
标 题:Thionolactones, processes of synthesis, uses as comonomers and for polymer functionalization and degradation
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 397.
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