CAS: 7781-98-8; Ethyl 3-Hydroxybenzoate

上下游产品

CAS号64-17-5 乙醇 | CAS号99-06-9 3-羟基苯甲酸 | CAS号186821-36-3 4'-Ethoxy-4'-(3... | CAS号84751-41-7 ethyl (1SR,2RS,... | CAS号64-67-5 硫酸二乙酯 | CAS号10259-22-0 3-甲氧基苯甲酸乙酯 | CAS号104354-26-9 Benzoic acid, 3... | CAS号3739-38-6 3-苯氧基苯甲酸 | CAS号3586-15-0 3-苯氧基苯甲酰氯 | CAS号5432-17-7 间乙氧基苯甲酸乙酯 | CAS号33668-25-6 3-氧代环己烷甲酸乙酯 | CAS号93-89-0 苯甲酸乙酯 | CAS号94160-25-5 3-羟基环己烷羧酸乙酯 | CAS号203187-56-8 3-羟基-4-碘苯甲酸乙酯 | CAS号284462-56-2 3-(4-aminopheno... | CAS号93351-38-3 3-丁氧基苯甲酸

2-乙氧羰基苯硼酸置于tert-Butylammonium Hexafluorophosphate(V),N,N'-Dimethyl-4,4'-Bipyridinium Dihexafluorophosphate,三乙胺体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,以86%的收率获得产物3-羟基苯甲酸乙酯
参考文献:Metal-Free Electrocatalytic Aerobic Hydroxylation Of Arylboronic Acids
标题:Metal-Free Electrocatalytic Aerobic Hydroxylation Of Arylboronic Acids
摘要:Hydroxylation Of Arylboronic Acids To Aryl Alcohols Was Realized By A Scalable Electrocatalytic Method. The Present Electrochemical Hydroxylation Employs Low-Cost Methyl Viologen As An Organic Cathodic Electrocatalyst And Involves O-2 As A Green And Sustainable Reactant. The Electrocheinical Kinetic Studies Shown Here Can Be A Powerful Tool To Gain Rich Mechanistic And Kinetic Information And Thus An In-Depth Understanding Of The Electrocatalytic Mechanism.
DOI:10.1021/acs.Orglett.7B02483

专利信息

专利号:US-7442802-B2
优先权日:2002-06-27
标 题:Cyclooxygenase-2 selective inhibitors, compositions and methods of use
发明人：BANDARAGE UPUL K; EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; KHANAPURE SUBHASH P; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

专利号:US-2023117370-A1
优先权日:2020-04-17
标 题:Regioselective synthesis of substituted compounds
发明人：BEAUDRY CHRISTOPHER M; ZHANG XIAOJIE
权利人:UNIV OREGON STATE
摘要:Disclosed herein are embodiments of a method for making substituted compounds with specific and selectable regiochemistry. Also disclosed are compounds made by the method. The method may comprise contacting a compound having a formula Iwith a compound according to formula IIin the presence of a Lewis acid to form a phenol compound according to formula III and/or a benzofuranone compound according to formula IV

专利号:US-8193192-B2
优先权日:2006-08-29
标题 :Heterocyclic FXR binding compounds
发明人：KREMOSER CLAUS; DEUSCHLE ULRICH; ABEL ULRICH; SCHULZ ANDREAS
权利人:KREMOSER CLAUS; DEUSCHLE ULRICH; ABEL ULRICH; SCHULZ ANDREAS; PHENEX PHARMACEUTICALS AG
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists or partial agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:US-8524740-B2
优先权日:2010-07-15
标 题 :Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives
发明人：KUO SHENG-CHU; LEE KUO-HSIUNG; HUANG LI-JIAU; CHOU LI-CHEN; WU TIAN-SHUNG; WAY TZONG-DER; CHUNG JING-GUNG; YANG JAI-SING; HUANG CHI-HUNG; TSAI MENG-TUNG
权利人:KUO SHENG-CHU; LEE KUO-HSIUNG; HUANG LI-JIAU; CHOU LI-CHEN; WU TIAN-SHUNG; WAY TZONG-DER; CHUNG JING-GUNG; YANG JAI-SING; HUANG CHI-HUNG; TSAI MENG-TUNG; TAIRX INC
摘要:A compound of Formula I is disclosed as follows: n n n n n n n n n n n n or a pharmaceutically acceptable salt, prodrug, solvate, or metabolite thereof, wherein n R is hydrogen, P(â•?O)(OH) 2 , P(â•?O)(O(C 1 -C 18 )alkylene(C 6 -C 20 )aryl) 2 , P(â•?O)(OH)(OM), P(â•?O)(OM) 2 , Pâ•?O(O 2 M), S(â•?O)(OH) 2 , S(â•?O)(O(C 1 -C 18 )alkylene(C 6 -C 20 )aryl) 2 , S(â•?O)(OH)(OM), S(â•?O)(OM) 2 ; n M is a monovalent or divalent metal ion, or alkylammonium ion; n W is (C 6 -C 20 )aryl, (C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkyl(C 6 -C 20 )aryl, (C 1 -C 18 )alkyl(C 6 -C 20 )heteroaryl, hydroxy(C 6 -C 20 )aryl, hydroxy(C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkoxy(C 6 -C 20 )aryl, (C 1 -C 18 )alkoxy(C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkylenedioxy(C 6 -C 20 )aryl, (C 1 -C 18 )alkylenedioxy(C 6 -C 20 )heteroaryl, halo(C 6 -C 20 )aryl, halo(C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkylamino(C 6 -C 20 )aryl, (C 1 -C 18 )alkylamino(C 6 -C 20 )heteroaryl, (C 1 -C 18 )cycloalkylamino(C 6 -C 20 )aryl, or (C 1 -C 18 )cycloalkylamino(C 6 -C 20 )heteroaryl, and their OR 8 substutes; n R 5 is (C 1 -C 18 alkoxy, hydrogen, hydroxyl, O—(C 1 -C 18 )alkyl(C 6 -C 20 )aryl, halo or OR 8 , or R 5 and R 6 are (C 1 -C 18 )dioxy provided that R 7 is hydrogen; n R 6 is hydroxyl, O—(C 1 -C 18 )alkyl(C 6 -C 20 )aryl, halo or OR 8 , (C 1 -C 18 )alkoxy, (C 1 -C 18 )alkylamino, or (C 1 -C 18 )cycloalkylamino, or R 6 and R 7 are (C 1 -C 18 )dioxy provided that R 5 is hydrogen; n R 7 is hydrogen, halo or OR 8 , hydroxyl, or O—(C 1 -C 18 )alkyl(C 6 -C 20 )aryl; and n R 8 is P(â•?O)(OH) 2 , P(â•?O)(O(C 1 -C 18 )alkyl(C 6 -C 20 )aryl) 2 , Pâ•?O)(OH)(OM), or P(â•?O)(OM) 2 , Pâ•?O(O 2 M).

专利号:US-11180523-B2
优先权日:2016-01-04
标 题 :Design, synthesis and use of synthetic nucleotides comprising charge mass tags
发明人：O'HALLORAN JONATHAN J; HEDLEY JOSEPH H
权利人:QUANTUMDX GROUP LTD
摘要:Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.