CAS: 637-96-7; 2-(Methylamino)Acetic Acid Hydrochloride

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107-97-1 1138-80-3 13734-36-6

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chloroacetic acid methylamine1-Methyl-4-(2-nitro-phenyl)-1H-pyrrole-2-carboxylic acid ethyl ester N-(9-fluorenylmethoxycarbonyl)sarcosine methyl-2-((4-(5-(((4-fluorophenyl)(isopropyl)amino)methyl)thiophen-2-yl)benzyl)(methyl)amino)acetate 3-(3,5-dichlorophenyl)-1-methyl-2,4-imidazolidinedione

📜氯乙酸,甲胺置于碳酸氢钠,盐酸体系中,用 水 作为反应溶剂,化学反应 24.5H,以63%的收率获得产物盐酸肌氨酸
参考文献:Synthesis,Characterization,Spectroscopy,Cytotoxic Activity And Molecular Dynamic Study On The Interaction Of Three Palladium Complexes Of Phenanthroline And Glycine Derivatives With Calf Thymus Dna
标题:Synthesis,Characterization,Spectroscopy,Cytotoxic Activity And Molecular Dynamic Study On The Interaction Of Three Palladium Complexes Of Phenanthroline And Glycine Derivatives With Calf Thymus Dna
摘要:The Interaction Of Three Novel Synthesized Complexes Of [pd(Phen)(R-Gly)]No3,Where R-Gly Is Methyl-,Propyl-,And Amyl-Glycine; And Phen Is 1,10-Phenanthroline Were Synthesized And Characterized By Spectroscopic Methods. The Interaction Of Ct-Dna With Different Concentrations Of These Palladium(II) Complexes Were Studied By Uv-Vis,Fluorescence,Circular Dichroism Spectroscopy,Viscometric,And Voltammetric Measurements In Tris-Hcl Buffer Solution Containing 10 Mm Sodium Chloride (Ph 7.2) At 27 And 37 Degrees C As Well As Molecular Dynamics (Md) Simulation And Molecular Docking. The Biological Activity Of The Synthesized Pd(II) Complexes Was Tested Against Chronic Myelogenous Leukemia Cell Line K562 At Micromolar Concentrations. Binding Constants Obtained By Uv-Vis Spectroscopy For Methyl,Propyl And Amyl Derivatives Are As 5.08 X 10(5),5.55 X 10(5),7.08 X 10(5) At 27 Degrees C And 5.53 X 10(5),6.54 X 10(5),10.01 X 10(5) M-1 At 37 Degrees C,Respectively. The Experimental Results Suggested That These Complexes Cooperatively Bind To Dna Presumably Via Intercalation. Moreover,These Pd(II) Complexes Showed Higher Tendency To Interact With Dna At Higher Concentrations And Temperatures. These Pd Complexes Increase The T-M,Viscosity,And Helicity Of Dna Solution. The Binding Data Shows That Methyl-Derivative Has Higher Tendency For Binding To Dna. The Trend Of Changes In The Structural Parameters Such As Calculated Asa,Rmsd,Hydrogen Bond,And Experimental Viscosity Were Amyl > Propyl > Methyl. The Results Suggest That The Synthesized Pd(II) Complexes Have Dose-Response Suppression On Growing Of K562 Leukemia Cell Line. Also,According To Cc(50) Values,It Is Clear That The Pd(II) Complex Of Methylglycine Has Higher Cytotoxic Or Anti-Proliferative Effect Against K562 Leukemia Cell Line. (C) 2015 Elsevier B.V. All Rights Reserved.
DOI:10.1016/j.Ica.2015.03.006

专利信息

专利号:US-12264135-B2
优先权日:2018-08-24
标 题 :Synthesis of 1,4-diazaspiro[5.5]undecan-3-one
发明人：SCHNEIDER STEPHEN E; WHITE HANNAH; FESSARD THOMAS; BELDAR SAGAR
权利人:PHARMACOSMOS HOLDING AS
摘要:This invention provides a process for preparing 1,4-diazaspiro[5.5]undecan-3-one and analogues thereof that are useful in the preparation of pharmaceutical compound, including for the treatment of disorders involving abnormal cellular proliferation. Chemical intermediates in the process are also provided.

专利号:US-5532366-A
优先权日:1992-07-02
标 题:Heterocyclic amides
发明人：EDWARDS PHILIP D; WARNER PETER; WOLANIN DONALD J
权利人:ZENECA LTD
摘要:The present invention relates to certain novel amide derivatives which are pyrido[3,4-d]pyrimidin-7-ylacetamides which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these amide derivatives, processes for preparing the amide derivatives, pharmaceutical compositions containing such amide derivatives and methods for their use.

专利号:US-11708337-B2
优先权日:2018-08-24
标题:Synthesis of 1,4-diazaspiro[5.5]undecan-3-one

专利号:US-7250410-B2
优先权日:2001-06-07
标题:Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
发明人：BOURGUIGNON JEAN-JACQUES; LAGOUGE YAN; LUGNIER CLAIRE; KLOTZ EVELINE; MACHER JEAN-PAUL; RABOISSON PIERRE; SCHULTZ DOMINIQUE
权利人:VIA PHARMACEUTICALS INC
摘要:The invention concerns novel benzodiazepine derivatives and their uses in the field of therapeutics particularly for treating pathologies involving the activity of a cyclic nucleotide phosphodiesterase. It also concerns methods for preparing them and novel synthesis intermediates. The inventive compounds more particularly correspond to general formula (I):

专利号:US-6225052-B1
优先权日:1997-02-24
标题:Method for determining a nucleic acid
发明人：BATZ HANS-GEORG; HANSEN HENRIK FRYDENLUND; ORUM HENRIK; KOCH TROELS; SCHUSTER GARY B; ARMITAGE BRUCE A; LY DANITH
权利人:ROCHE DIAGNOSTICS GMBH; GEORGIA TECH RES INST
摘要:New electron transfer moiety labeled nucleic acid analogue probes are provided that can be used in methods for determining nucleic acids in a sample. The new probes can be prepared using novel monomer subunits in a chemical synthesis route. The nucleic acids can be determined by binding the probe molecules to the nucleic acid and inducing electron transfer within the complex formed. The occurrence of the electron transfer is determined as a measure of the nucleic acid.

专利号:EP-0968309-B1
优先权日:1997-02-24
标题:Method for determining a nucleic acid
发明人：BATZ HANS-GEORG; HANSEN HENRIK FRYDENLUND; RUM HENRIK; KOCH TROELS; SHUSTER GARY B; ARMITAGE BRUCE A; LY DANITH
权利人:GEORGIA TECH RES INST; ROCHE DIAGNOSTICS GMBH
摘要:New electron transfer moiety labeled nucleic acid analogue probes are provided that can be used in methods for determining nucleic acids in a sample. The new probes can be prepared using novel monomer subunits in a chemical synthesis route. The nucleic acids can be determined by binding the probe molecules to the nucleic acid and inducing electron transfer within the complex formed. The occurrence of the electron transfer is determined as a measure of the nucleic acid.