CAS: 627-41-8; 3-Methoxyprop-1-Yne

该化合物是一种挥发性,易燃液体,分子式为C4H6O.其特征是其终端烷基和醚功能组,使其成为有机合成的多用途中间体.该化合物因其在点击化学中的作用而特别受到重视,因为它在点击化学中参与了铜催化烷基环球增殖反应,其相对较低的沸点和再活性能够有效地融入复杂的分子框架.甲基丙基醚还被用于制作特殊聚合物和药品.适当的处理由于其易燃性和在某些条件下对聚合性的潜在敏感性而必不可少.

结构式图片

相似化合物

16356-02-8 31995-08-1 764-01-2

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号107-19-7 丙炔醇 | CAS号77-78-1 硫酸二甲酯 | CAS号67-56-1 甲醇 | CAS号106-96-7 溴代丙炔 | CAS号5836-66-8 2,3-Dibromoprop... | CAS号74-88-4 碘甲烷 | CAS号96-11-7 1,2,3-三溴丙烷 | CAS号37675-34-6 (E)-1-bromo-3-m... | CAS号40365-61-5 2-(3-丁炔氧基)四水-2H-吡喃 | CAS号1072-25-9 deca-1,2-diene | CAS号557-17-5 甲基丙基醚 | CAS号627-40-7 烯丙基甲基醚 | CAS号503-17-3 2-丁炔 | CAS号2768-41-4 1-methoxybut-2-yne | CAS号18495-20-0 1-methoxypent-2-yne | CAS号22433-33-6 1,2-Nonadiene | CAS号21752-80-7 trimethyl(3-tri... | CAS号18857-03-9 4-methoxybut-2-... | CAS号220649-65-0 2-(3-甲氧基-1-丙炔)苯甲醛

合成工艺路线路线简述

    1,2-二溴-3-甲氧基丙烷置于氢氧化钾体系中,化学反应生成 甲基炔丙基醚
    参考文献:Bourguel,Annales De Chimie (Cachan,France),1925,Vol. <10> 3,P. 221
    标题:Bourguel,Annales De Chimie (Cachan,France),1925,Vol. <10> 3,P. 221

    海关参考信息

    专利信息


    专利号:US-2025026768-A1
    优先权日:2023-06-30
    标题:Method for the synthesis of axially chiral organoboron compounds
    发明人:PING YIFAN; CHE CHI-MING
    权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
    摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.

    专利号:US-5286901-A
    优先权日:1990-03-09
    标题:Prescursors for and synthesis of mono- and difunctionalized acetylenes and difunctional 1,3-diynes
    发明人:STANG PETER J; CRITTELL CHARLES M; WILLIAMSON BOBBY L; ZHDANKIN VIKTOR
    权利人:UNIV UTAH RES FOUND
    摘要:Precursors and methods for the synthesis of mono- and difunctionalized acetylenes are described. The invention includes novel tricoordinate iodonium transfer reagents and novel alkynyldi(phenyliodonium) salts, both of which are precursors for the functionalized acetylenes. The iodonium transfer reagents take the general form of mixed iodonium sulfonates PhI + (X)OSO 2 R f , where X may be OAc, NHAc, NCO, or CN. These mixed iodonium sulfonates are produced by reaction of iodosobenzene with certain substituted trimethylsilanes. n To make the alkynyldi(phenyliodonium) salt PhI + C.tbd.CI + Ph•2 R f SO 3 - ,a mixed iodonium sulfonate is reacted with a bistin acetylene of the kind R' 3 SnC.tbd.CSnR' 3 . Alternatively, the reaction may be performed with disubstituted tin diacetylenes to produce PhI + C.tbd.C-C.tbd.CI + Ph•2 R f SO 3 - to produce a dialkynyldi(phenyliodonium) salt. Subsequent reaction of a nucleophile with the alkynyldi(phenyl-iodonium) salt or dialkynyldi(phenyliodonium) salt produces a difunctional acetylene or a difunctional 1,3-diyne, respectively.

    专利号:US-8183355-B2
    优先权日:2006-04-28
    标题 :Method for the synthesis of oligonucleotide derivatives
    发明人:MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE
    权利人:MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE; CENTRE NAT RECH SCIENT
    摘要:Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistryâ€? reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. n Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.

    专利号:US-7109377-B2
    优先权日:1996-10-16
    标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
    发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
    权利人:HARVARD COLLEGE
    摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

    专利号:WO-2025083208-A1
    优先权日:2023-10-19
    标题 :Synthesis of morpholine derivatives and compounds therefore
    发明人:BUESCHLEB MARTIN; BEAUFILS FLORENT; PROUDFOOT JOHN
    权利人:BOEHRINGER INGELHEIM INT
    摘要:The present invention relates to a synthesis method for morpholine derivatives, including a ring-formation out of a 1,2-amino alcohol and a compound of formula (I) whereby LG is a nucleophilic leaving group and R1 to R7 are as herein defined.

    专利号:US-10815178-B2
    优先权日:2015-12-21
    标 题:Intermolecular reaction of propargyl ethers with dimethylfuran in the presence of gold(I) complexes
    发明人:LETINOIS ULLA; ACKERMANN STEPHAN; MEDLOCK JONATHAN ALAN; LEHMANN HAJO
    权利人:DSM IP ASSETS BV
    摘要:The present invention relates to a method of preparing ortho substituted phenols from 2,5-dimethylfuran and propargyl ethers in the presence of a gold(I) complex. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of said ortho substituted phenols.
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    合成参考文献


    摘要:Baird, M. S., Science of Synthesis, (2010) 47, 1111.
    摘要:Kantchev, E. A. B.; Organ, M. G., Science of Synthesis, (2009) 48, 25.
    摘要:Aguilar, E.; López, L. A., Science of Synthesis Knowledge Updates, (2014) 2, 116.
    摘要:Durand, A.; Hemeon, I.; Singer, R. D., Science of Synthesis Knowledge Updates, (2013) 2, 144.
    摘要:Sainsbury, M., Science of Synthesis Knowledge Updates, (2010) 1, 239.
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