CAS: 589-41-3; Ethyl N-Hydroxycarbamate

相似化合物

36016-38-3 3426-71-9 19689-97-5

📜氯甲酸乙酯置于盐酸羟胺,Sodium Hydroxide体系中,用 水 作为反应溶剂,以72 %的收率获得产物n-羟基氨基甲酸乙酯
参考文献:酰亚硝基烯反应区域选择性和立体选择性合成小白菊内酯类似物及其抗结核分枝杆菌的生物学评价.
标题:酰亚硝基烯反应区域选择性和立体选择性合成小白菊内酯类似物及其抗结核分枝杆菌的生物学评价.
摘要:从历史上看,天然产物在抗生素的开发中发挥了重要作用.它们复杂的化学结构和高极性使它们在药物发现过程中具有优势.在广泛的天然产物中,倍半萜内酯是令人感兴趣的化合物,因为它们具有多种生物活性,高极性和富含sp3碳的化学结构.小白菊内酯 (Ptl) 是从 Tanacetum Parthenium 中分离出来的天然化合物,属于germacranolide 型倍半萜内酯家族.近年来,人们对小白菊内酯的抗炎,抗偏头痛和抗癌特性进行了研究.最近,Ptl显示出抗菌活性,特别是针对革兰氏阳性菌.然而,关于小白菊内酯及其类似物的潜在抗结核活性的研究很少.已经证明,小白菊内酯的生物效应与 α-外型-亚甲基-γ-丁内酯的反应性有关,α-外型-亚甲基-γ-丁内酯通过迈克尔加成与目标蛋白质中的半胱氨酸发生反应.在这项工作中,我们描述了酰亚硝基中间体与小白菊内酯的烯反应,导致新衍生物的区域选择性和立体选择性合成及其生物
DOI:10.3390/ijms242417395

专利信息

专利号:US-5571677-A
优先权日:1993-07-02
标题:Convergent synthesis of branched and multiply connected macromomolecular structures
发明人：GRYAZNOV SERGEI M
权利人:LYNX THERAPEUTICS INC
摘要:The invention provides methods and compositons for convergent synthesis of branched polymers useful as molecular probes. The invention also includes several novel branched polymeric structures particularly useful for detecting target polynucleotides. Branched polymers of the invention comprise at least two branches: at least one branch is a target binding moiety capable of specifically binding to a target molecule of interest and one or more branches are signal generation moities capable of directly or indirectly generating a detectable signal. In accordance with the method of the invention branched polymers are assembled from components having phosphorothioate groups and/or haloacyl- or haloalkylamino groups. The phosphorothioate and haloacyl- or haloalkylamino groups react rapidly and efficiently when brought into contact to form thiophosphorylacyl- or thiophosphorylalkylamino bridges which.complete the assembly of a branched polymer. The method of the invention permits thorough purification and isolation of the components prior to final assembly. Incomplete branched polymers are readily separated from the desired product by standard means. The method of the invention permits the synthesis of several novel branched polymer configurations.

专利号:US-5830658-A
优先权日:1995-05-31
标 题 :Convergent synthesis of branched and multiply connected macromolecular structures
发明人：GRYAZNOV SERGEI M
权利人:LYNX THERAPEUTICS INC
摘要:The invention provides methods and compositons for convergent synthesis of branched polymers useful as molecular probes. The invention also includes several novel branched polymeric structures particularly useful for detecting target polynucleotides. Branched polymers of the invention comprise at least two branches: at least one branch is a target binding moiety capable of specifically binding to a target molecule of interest and one or more branches are signal generation moities capable of directly or indirectly generating a detectable signal. In accordance with the method of the invention branched polymers are assembled from components having phosphorothioate groups and/or haloacyl- or haloalkylamino groups. The phosphorothioate and haloacyl- or haloalkylamino groups react rapidly and efficiently when brought into contact to form thiophosphorylacyl- or thiophosphorylalkylamino bridges which complete the assembly of a branched polymer. The method of the invention permits thorough purification and isolation of the components prior to final assembly. Incomplete branched polymers are readily separated from the desired product by standard means. The method of the invention permits the synthesis of several novel branched polymer configurations.

专利号:WO-2021233976-A1
优先权日:2020-05-19
标 题 :Process for the synthesis of isocyanate-free omega-hydroxy-urethanes, alpha-omega-diurethanes and oligo (poly)urethanes
发明人：NOCITO FRANCESCO; ARESTA MICHELE; DIBENEDETTO ANGELA
权利人:CONSORZIO INTERUNIVERSITARIO NAZ PER LA REATTIVITA CHIMICA E LA CATALISI; CATALISI INNOVATIVA PER IL RICICLO DEL CARBONIO E BIOPOLIMERI S R L
摘要:The synthesis of omega-hydroxyalkyl-urethanes, and of alfa-omega-diurethanes is reported which includes the reaction of diols with urea in presence of catalysts based on Ce at temperatures between 125 and 170°C over 4-8 h reaction time. A process for the production of oligomers of omega-hydroxyalkyl-urethanes is also reported based on the reaction of urea with diols in presence of Ce or Zr catalysts or Ce mixed oxides at 125-170°C over 4-20 h.

专利号:WO-2024042405-A1
优先权日:2022-08-26
标 题:Compositions and methods for the synthesis of bio-based polymers
发明人：OLIVEIRA ANA; CAPÊTO ANA PAULA; PINTADO MANUELA
权利人:AMYRIS BIO PRODUCTS PORTUGAL UNIPESSOAL LTDA; UNIV CATOLICA PORTUGUESA
摘要:The present disclosure provides compositions and methods for the synthesis of bio-based polymers (e.g., polyurethanes and polyesters) from secondary materials produced during a fermentation process. The disclosure also features intermediates produced during these processes, as well as compositions containing the same.

专利号:US-6180777-B1
优先权日:1996-01-12
标 题 :Synthesis of branched nucleic acids
发明人：HORN THOMAS
权利人:BAYER AG
摘要:Branched polymers and multiply connected macromolecular structures are provided, wherein the polymers and structures are provided, wherein the polymers are structures comprise at least two branches and/or macrocycles, at least one of which is a target binding moiety capable of binding to a target molecule of interest, and at least another of which is a signal generation moiety capable of directly or indirectly generating a signal. These polymers and structures contain components that are linked through sulfur-containing bridges that are selectively cleaved by oxidation, e.g. thiophosphorylacyl, dithiophosphorylacyl, thiophosphorylthio, thiophosphorylalkylamino and/or dithiophosphorylalkylamino bridges, Synthetic methods are also provided, as are kits containing a complexing buffer and a nucleic acid probe composed of the branched polymer or macromolecular structure.

专利号:US-8987504-B2
优先权日:2010-06-18
标题 :Aminohydroxylation of alkenes
发明人：MEE SIMON PETER HAROLD; LUXENBURGER ANDREAS; HARRIS LAWRENCE DANIEL
权利人:MEE SIMON PETER HAROLD; LUXENBURGER ANDREAS; HARRIS LAWRENCE DANIEL; VICTORIA LINK LTD
摘要:The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relates to an intermolecular aminohydroxylation reaction that can be carried out in the absence of added base. The invention also relates to novel N-oxycarbamate reagents that are stable crystalline materials. The process of the invention is useful in the synthesis of compounds having a vicinal amino alcohol moiety, such as biologically active compounds.