CAS: 54594-06-8; H-D-Gly(Allyl)-Oh
该化合物是一种氨酸衍生物,其特点是存在附于甘蓝脊柱的Allyls组,其分子结构具有简单的氨基组(-NH2),一个碳球酸组(-COOH)和一个 allyl侧链,有助于其独特的再活动性和特性.该化合物已知是某些酶的抑制剂,特别是那些参与...
- 英文名称H-D-Gly(Allyl)-Oh
- 中文名称D-烯丙基甘氨酸
- IUPAC名称(R)-2-aminopent-4-enoic acid
- 其它别名(R)-Allylglycine (>, >ee) (H-D-Allylgly-Oh); H-D-Allylglycine; (+)-Allylglycine; (R)-2-Amino-4-Pentenoicacid; (2R)-2-Amino-4-Pentenoic Acid; Morpholinopropionitrile; D-Allylglycine; [(Tert-Butoxycarbonyl)Amino]Acetic Acid; A Inverted Exclama
- CAS编号54594-06-8
- MFCD编号:MFCD00063104
- EINECS号:880-265-4
- 分子式:C5H9NO2分子量:115.13
- 产品CID: 2498078
- 产品分类有机原料→生命科学→氨基酸及其衍生物→甘氨酸及其衍生物
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: WNNNWFKQCKFSDK-SCSAIBSYSA-N
- InChI=1S/C5H9NO2/c1-2-3-4(6)5(7)8/h2,4H,1,3,6H2,(H,7,8)/t4-/m1/s1
- 计算化学: 氢键受体数2.0氢键供体数2可旋转键数3
相似化合物
7685-44-1 146549-21-5 16338-48-0物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号100516-55-0 (3S,5S,6R)-4-(b... | CAS号422570-18-1 (1R,2S,5R,8S)-5... | CAS号105816-57-7 (R)-2-phthalimi... | CAS号106-95-6 烯丙基溴 | CAS号56-40-6 甘氨酸 | CAS号188359-85-5 (1R)-(1-羟甲基-丁-3... | CAS号170642-28-1 Fm°C-D-烯丙基甘氨酸 | CAS号16937-99-8 B°C-D-亮氨酸 | CAS号170899-08-8 B°C-D-烯丙基甘氨酸合成工艺路线路线简述
📜(2R,Rs)-2-(Tert-Butylsulfinamido)Pent-4-Enoic Acid置于盐酸体系中,用 水 作为反应溶剂,化学反应 4.0H,以69%的收率获得产物d-烯丙基甘氨酸
参考文献:Diastereoselective Amidoallylation Of Glyoxylic Acid With Chiral Tert-Butanesulfinamide And Allylboronic Acid Pinacol Esters: Efficient Synthesis Of Optically Active γ,δ-Unsaturated α-Amino Acids
标题:Diastereoselective Amidoallylation Of Glyoxylic Acid With Chiral Tert-Butanesulfinamide And Allylboronic Acid Pinacol Esters: Efficient Synthesis Of Optically Active γ,δ-Unsaturated α-Amino Acids
摘要:A Convenient Synthesis Of Delta,Gamma-Unsaturated Amino Acids Has Been Developed. After A Mixture Of (R)-Tert-Butanesulfinamide And Glyoxylic Acid With Molecular Sieves In Ch2Cl2 Was Stirred For 42 H At Room Temperature,Allylboronic Acid Pinacol Ester Was Added To The Mixture To Give (R)-2-((R)-Tert-Butanesulfinamido)Pent-4-Enoic Acid With High Diastereoselectivity. The Corresponding Reaction Of (Z)-Crotylboronic Acid Pinacol Ester Produced No Product; However,That Of (E)-Crotylboronic Acid Pinacol Ester Produced (2R,3S)-2-((R)-Tert-Butylsulfinamido)-3-Methylpent-4-Enoic Acid With Excellent Diastereoselectivity. (C) 2013 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetasy.2013.07.026
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905121000-正丙醇
2905130000-正丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2012282180-A1
优先权日:2011-05-06
标题 :Compounds with Matrix-Metalloproteinase Inhibitory Activity and Imaging Agents Thereof
发明人：KOLB HARTMUTH C; HAUFE GUENTER; BEHRENDS MALTE; KOPKA KLAUS; WAGNER STEFAN; HUGENBERG VERENA; BREYHOLZ HANS-JOERG; HERMANN SVEN; SCHAEFERS MICHAEL
权利人:KOLB HARTMUTH C; HAUFE GUENTER; BEHRENDS MALTE; KOPKA KLAUS; WAGNER STEFAN; HUGENBERG VERENA; BREYHOLZ HANS-JOERG; HERMANN SVEN; SCHAEFERS MICHAEL
摘要:The present invention relates to the field of therapeutic and diagnostic agents and more specifically to compounds of formula (I) that are inhibitors of matrix-metalloproteinases (MMPs) and are useful in the treatment of diseases related thereto such as cardiovascular diseases, inflammatory diseases and malignant diseases. One embodiment of the invention is a compound of formula (I) labeled with a 18-fluorine atom having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the inhibitors of matrix-metalloproteinases (MMPs) of the invention or the corresponding labeled compounds useful as diagnostic imaging agents of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the inhibitors of matrix-metalloproteinases (MMPs) of the invention and of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention.
专利号:US-12234299-B2
优先权日:2018-11-22
标 题 :Peptides for inducing bacteriocin synthesis and methods to identify and/or select and/or optimize the same
发明人：MIGNOLET JOHANN; HOLS PASCAL; LEDESMA GARCÃ?A LAURA
权利人:SYNGULON S A; UNIV CATHOLIQUE LOUVAIN
摘要:Described herein is a peptide or peptidomimetic with a length of at least 6 residues comprising, consisting essentially of, or consisting of the sequence motif Xaa1-Trp-Xaa2-Xaa3-Xaa4-Xaa5 (SEQ ID NO:1), wherein: Xaa1 represents an aromatic residue (Phe, Tyr, Trp, His), Cys or Ser; Xaa2, Xaa3 and Xaa4 represent any residue; and Xaa5 represents Gly, lie or Val.
专利号:EP-3070087-B1
优先权日:2011-08-05
标题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors
专利号:EP-3070087-A1
优先权日:2011-08-05
标 题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors
专利号:EP-2520573-A1
优先权日:2011-05-06
标 题:Compounds with matrix-metalloproteinase inhibitory activity
发明人：HAUFE GUENTER; BEHRENDS MALTE; KOPKA KLAUS; WAGNER STEFAN; HUGENBERG VERENA; BREYHOLZ HANS-JOERG; HERMANN SVEN; SCHAEFERS MICHAEL; KOLB HARTMUTH
权利人:UNIV MUENSTER WILHELMS; SIEMENS MEDICAL SOLUTIONS
摘要:The present invention relates to the field of therapeutic and diagnostic agents and more specifically to compounds of formula (I) that are inhibitors of matrix-metalloproteinases (MMPs) and are useful in the treatment of diseases related thereto such as cardiovascular diseases, inflammatory diseases and malignant diseases. One embodiment of the invention is a compound of formula (I) labeled with a 18-fluorine atom having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the inhibitors of matrix-metalloproteinases (MMPs) of the invention or the corresponding labeled compounds useful as diagnostic imaging agents of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the inhibitors of matrix-metalloproteinases (MMPs) of the invention and of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.[参考文献]: Irena Berezowska, Et Al. Cyclic Opioid Peptide Agonists And Antagonists Obtained Via Ring-Closing Metathesis. Chem Biol Drug Des. 2009 Oct;74(4):329-34.
[参考文献]: Pl Johnson, Et Al. Disruption Of Gabaergic Tone In The Dorsomedial Hypothalamus Attenuates Responses In A Subset Of Serotonergic Neurons In The Dorsal Raphe Nucleus Following Lactate-Induced Panic. J Psychopharmacol. 2008 Aug;22(6):642-52.
[参考文献]: Stephan Urwyler, Et Al. Drug Design, In Vitro Pharmacology, And Structure-Activity Relationships Of 3-Acylamino-2-Aminopropionic Acid Derivatives, A Novel Class Of Partial Agonists At The Glycine Site On The N-Methyl-D-Aspartate (Nmda) Receptor Complex. J Med Chem. 2009 Aug 27;52(16):5093-107.
[参考文献]: Tadashi Saigusa, Et Al. In Vivo Neurochemical Evidence That Newly Synthesised Gaba Activates Gaba(B), But Not Gaba(A), Receptors On Dopaminergic Nerve Endings In The Nucleus Accumbens Of Freely Moving Rats. Neuropharmacology. 2012 Feb;62(2):907-13.
合成参考文献
摘要:Hall, M.; Faber, K.; Tasnádi, G., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 310.
摘要:Hall, M.; Faber, K.; Tasnádi, G., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 305.
参考文献:10.1007/bf01388171
摘要:Meffre P. Syntheses of optically active 2-amino-4-oxobutyric acid and N,O-protected derivatives. Amino Acids. 1999;16(3-4):251–72. doi: 10.1007/bf01388171.
📝 需求与反馈
尽可能描述清楚需求与问题信息
