CAS: 5381-25-9; 1-Benzothiophene-3-Carboxylic Acid

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CAS号7342-82-7 3-溴苯并噻吩 | CAS号124-38-9 二氧化碳 | CAS号201230-82-2 carbon monoxide | CAS号67-56-1 甲醇 | CAS号36748-88-6 3-碘苯并[b]噻吩 | CAS号74-88-4 碘甲烷 | CAS号95-15-8 苯并噻吩 | CAS号1128-05-8 3-乙酰硫茚 | CAS号3216-47-5 2-氯-3-甲基苯并(b)噻吩 | CAS号5381-20-4 3-甲醛苯并噻吩 | CAS号39827-12-8 1-苯并噻吩-3-羰酰氯 | CAS号5381-24-8 3-羟甲基苯并噻吩 | CAS号7312-24-5 5-溴苯并[B]噻吩-3-甲酸 | CAS号19075-61-7 6-BROMO-BENZO[B... | CAS号1131-09-5 苯并[b]噻吩-3-乙酸 | CAS号22913-25-3 苯并噻吩-3-羧酸甲酯

📜3-碘苯并[b]噻吩置于乙醚,Magnesium体系中,化学反应生成 1-苯并噻吩-3-羧酸
参考文献:Bromination,Iodination And Phenylation Of Thianaphthenes
标题:Bromination,Iodination And Phenylation Of Thianaphthenes
摘要:
DOI:10.1021/ja01139A508

专利信息

专利号:US-11414375-B2
优先权日:2016-07-29
标题:Mild and efficient preparation method for α-acyloxyenamide compounds and use thereof in synthesis of amide and polypeptide
发明人：ZHAO JUNFENG; HU LONG; XU SILIN; ZHAO ZHENGUANG
权利人:UNIV JIANGXI NORMAL
摘要:Disclosed are a mild and efficient preparation method for an α-acyloxyenamide compound and a use thereof in the synthesis of an amide and a polypeptide. The α-acyloxyenamide compound is obtained by an addition reaction of a ynamide and a carboxylic acid in dichloromethane under conditions where the temperature is 0° C. to 50° C.; the produced α-acyloxyenamide compound can react with an amine compound to produce an amide or a polypeptide; the two reactions can be carried out step by step, and can also be carried out in one pot. According to the invention, the reaction conditions are mild and no metal catalyst is required; when the carboxylic acid, which has chirality on an alpha site of carboxyl, forms an amide bond or a peptide bond, no racemization occurs; and the operation is simple and the application range is wide.

专利号:US-2007275962-A1
优先权日:2003-09-10
标 题:Heterobicyclic Compounds as Pharmaceutically Active Agents
发明人：KOUL ANIL; KLEBL BERT; MULLER GERHARD; MISSIO ANDREA; SCHWAB WILFRIED; HAFENBRADL DORIS; NEUMANN LARS; SOMMER MARC-NICOLA; MULLER STEFAN; HOPPE EDMUND; FREISLEBEN ACHIM; BACKES ALEXANDER; HARTUNG CHRISTIAN; FELBER BEATRICE; ZECH BIRGIT; ENGKVIST OLA; KERI GYORGY; ORFI LASZLO; BANHEGYI PETER; GREFF ZOLTAN; HORVATH ZOLTAN; VARGA ZOLTAN; MARKO PETER; PATO JANOS; SZABADKAI ISTVAN; SZEKELYHID ZSOLT; WACZEK FRIGYES
权利人:GPC BIOTECH AG
摘要:Described are heterobicyclic compounds such as 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteriainduced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.

专利号:US-2020299226-A1
优先权日:2016-07-29
标题:Mild and efficient preparation method for a-acyloxyenamide compounds and use thereof in synthesis of amide and polypeptide

专利号:US-10836707-B2
优先权日:2016-07-29
标 题:Mild and efficient preparation method for α-acyloxyenamide compounds and use thereof in synthesis of amide and polypeptide

专利号:US-4224330-A
优先权日:1979-09-13
标题 :Esters and thiolesters of benzothienyl acids
发明人：HENRICK CLIVE A; LABOVITZ JEFFREY N; LEIPPE MICHAEL M; WOO SAM L
权利人:ZOECON CORP
摘要:Esters and thiolesters of benzothienyl acids, intermediates thereof, synthesis thereof, and the use thereof for the control of pests.

专利号:CN-106146359-A
优先权日:2016-07-29
标 题 :A mild and efficient preparation method of α-acyloxyenamides and its application in the synthesis of amides and peptides