CAS: 533-88-0; 2-Amino-5-Hydroxypentanoic Acid

该化合物是一种非蛋白性氨基酸衍生物,在第五碳位置上有一个氢氧基组,该化合物因其功能组而对有机合成和生化研究感兴趣,因为其功能组有助于多功能反应,包括peptide联动和修改,氨基和氢氧基组的存在允许选择性衍生,使其有助于开发专门的聚合物,制药中间体或生物活性分子,其结构特征还可能有助于切热或化学协调应用.该化合物通常在受控制的条件下处理,因为它可能具有对水分或氧化的敏感性.建议对特定应用进行进一步的定性.

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2169956-19-6 1956308-01-2 83345-45-3

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    上下游产品

    CAS号45025-28-3 glutamic acid 5... | CAS号109-64-8 1,3-二溴丙烷 | CAS号96-48-0 γ-丁内酯 | CAS号95-92-1 草酸二乙酯 | CAS号1499-55-4 L-谷氨酸-5-甲酯 | CAS号1191-99-7 2,3-二氢呋喃 | CAS号7647-01-0 盐酸 | CAS号115938-76-6 2-benzoylamino-... | CAS号7664-93-9 硫酸

    合成工艺路线路线简述

    • 56-86-0 = 533-88-0 + 498-63-5 + 63493-28-7 + 62400-75-3 + 98-79-3 + 40217-11-6 + 927-55-9 + 16369-14-5 + 21926-01-2
      反应条件:1.1 Reagents: Hydrogen,Phosphoric Acid Catalysts: Rhodium,Molybdenum Oxide Solvents: Water; 6 H,Ph 1.8,70 Bar,100 °C
      标题:Rh-Catalyzed Hydrogenation Of Amino Acids To Biobased Amino Alcohols: Tackling Challenging Substrates And Application To Protein Hydrolysates
      作者:Vandekerkhove,Annelies; Claes,Laurens; De Schouwer,Free; Van Goethem,Cedric; Vankelecom,Ivo F. J.; Et Al
      参考文献:Acs Sustainable Chemistry & Engineering 日期:2018 卷标:6(7) 页码:9218-9228
    📜Glutamic Acid 5-Ethyl Ester置于四氢呋喃,锂硼氢体系中,化学反应生成 2-氨基-5-羟基戊酸
    参考文献:Swallow; Abraham,Biochemical Journal,1959,Vol. 72,P. 326,327
    标题:Swallow; Abraham,Biochemical Journal,1959,Vol. 72,P. 326,327

    海关参考信息

    专利信息


    专利号:US-2023151394-A1
    优先权日:2020-03-31
    标题 :Biologic synthesis of diols from amino acids
    发明人:ZENG AN-PING; LIU YONGFEI
    权利人:TAIZHOU SIMPLU TECH CO LTD
    摘要:A method for the enzymatically catalyzed synthesis of a diol from an amino acid includes enzymatically hydroxylating the amino acid, enzymatically deaminating the amino acid, the deamination resulting in the formation of an oxo group at the position of the amino group, enzymatically decarboxylating the amino acid, and enzymatically hydrogenating the oxo group resulting from the deamination reaction.

    专利号:US-12084476-B2
    优先权日:2017-05-12
    标题 :Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors
    发明人:KAISER MARKUS; KÖCHER STEFFEN; REY JULIANA; BONGARD JENS; EHRMANN MICHAEL; RESCH SARAH
    权利人:UNIV DUISBURG ESSEN
    摘要:The present invention pertains to an improved chemical synthesis method for Ahp-cyclodepsipeptides which allows straight forward and easy synthesis of tailor-made Ahp-cyclodepsipeptides. The invention further provides Ahp-cyclodepsipeptides for use as HTRA protease inhibitors and their medical use.

    专利号:US-7452701-B2
    优先权日:1998-11-24
    标 题:Methods for the preparation of β-amino acids
    发明人:FREY PERRY A; RUZICKA FRANK J
    权利人:WISCONSIN ALUMNI RES FOUND
    摘要:Purified β-amino acids are of considerable interest in the preparation of pharmacologically active compounds and industrial precursors. Although enantiomerically pure β-amino acids can be produced by standard chemical synthesis, this traditional approach is time consuming, requires expensive starting materials, and results in a racemic mixture which must be purified further. However, DNA molecules encoding lysine 2,3-aminomutase can be used to prepare β-amino acids by methods that avoid the pitfalls of chemical synthesis. The present invention provides a method of producing enantiomerically pure β-amino acids from α-amino acids comprising catalyzing the conversion of an α-amino acid to a corresponding β-amino acid by utilizing a lysine 2,3-aminomutase as the catalyst.

    专利号:US-2009062211-A1
    优先权日:2003-03-05
    标 题:Conopeptides and methods of use
    发明人:MARI FRANK; FIELDS GREGG B
    权利人:UNIV FLORIDA ATLANTIC
    摘要:Isolation, synthesis and therapeutic use of conotoxin and conophan compounds and related compositions including a new class of conopeptides including the modified amino acid D-γ-hydro-oxyvalinie (D-Hyv=V*) are described herein. These isolated peptides are the first known example of a naturally occurring polypeptide chain containing D-Hyv. The active peptides, termed γ-Hydroxyconophans are heavily hydroxylated small peptides. These peptides contain a definitive structural motif which is a double modification of the polypeptide chain (γ-D-OH-Hyv-Trp).

    专利号:US-2006019892-A1
    优先权日:2003-03-05
    标 题:Conopeptides and methods of use
    发明人:MARI FRANK
    权利人:UNIV FLORIDA ATLANTIC
    摘要:Isolation, synthesis and therapeutic use of compounds and related compositions based on a new class of conopeptides comprising the modified amino acid γ-hydroxyvaline (Hyv=V*). These isolated peptides are the first known example of a naturally occurring polypeptide chain containing Hyv. The active peptides, termed γ-Hydroxyconophans are heavily hydroxylated small peptides. These peptides contain a definitive structural motif which is a double modification of the polypeptide chain (γ-OH-Hyv-D-Trp).

    专利号:US-2004167329-A1
    优先权日:2003-02-21
    标 题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process

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    合成参考文献


    参考文献:10.1016/0891-5849(96)00125-6
    摘要:Ayala A, Cutler RG. Comparison of 5-hydroxy-2-amino valeric acid with carbonyl group content as a marker of oxidized protein in human and mouse liver tissues. Free Radic Biol Med. 1996;21(4):551–8. doi: 10.1016/0891-5849(96)00125-6.
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