CAS: 519187-97-4; Edonerpic Maleate

英文名称Edonerpic Maleate
中文名称1-(3-(2-(苯并[B]噻吩-5-基)乙氧基)丙基)氮杂环丁烷-3-醇马来酸
IUPAC名称1-(3-(2-(benzo[b]thiophen-5-yl)ethoxy)propyl)azetidin-3-ol maleate
其它别名(Z)-But-2-Enedioic Acid | 1-(3-(2-(Benzo(B)Thiophene-5-Yl)Ethoxy)Propyl)Azetidine-3-Ol Maleate | 3-Azetidinol, 1-(3-(2-Benzo(B
CAS编号519187-97-4
MFCD编号:MFCD13152397
FDA UNII编号:0LB9F7I5P3
分子式:C20H25NO6S分子量:407.49
产品CID: 1510020
同类组份化合物CAS519187-23-6 (free base)519187-97-4 (maleate)
产品分类生物化工 → 生化试剂

相似结构搜索
InChIKey: RLUCYBFCLXANSO-BTJKTKAUSA-N
InChI=1S/C16H21NO2S.C4H4O4/c18-15-11-17(12-15)6-1-7-19-8-4-13-2-3-16-14(10-13)5-9-20-16;5-3(6)1-2-4(7)8/h2-3,5,9-10,15,18H,1,4,6-8,11-12H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
计算化学: 氢键受体数8.0氢键供体数3.0可旋转键数9.0

物理性质

PSA:135.54
LogP:2.1767
溶解性DMSO:90.5(Max Conc. mg/mL);222.1(Max Conc. Mm) Ethanol:40.0(Max Conc. mg/mL);98.16(Max Conc. Mm) Water:90.5(Max Conc. mg/mL);222.1(Max Conc. Mm)
外观形态白色至类白色固体
储存条件储存在 -20°C
产品应用该化合物用于实验室研究与开发过程和化学生产过程.

上下游产品

maleic acid 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-3-azetidinol (2E)-but-2-enedioic acid

合成工艺路线路线简述

📜顺丁烯二酸置于sodium Hydroxide体系中,用水,异丙醇作为反应溶剂,化学反应 1.0H,反应生成化合物edonerpicmaleate
参考文献:Alkyl Ether Derivatives Or Salts Thereof
标题:Alkyl Ether Derivatives Or Salts Thereof

海关参考信息

2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2905122000-异丙醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

1: Chen T, Yang LK, Ai P, Zhu J, Hang CH, Wang YH. Edonerpic maleate regulates glutamate receptors through CRMP2- and Arc-mediated mechanisms in response to brain trauma. Cell Death Discov. 2022 Mar 4;8(1):95. doi: 10.1038/s41420-022-00901-0.
2: Moutal A, Shan Z, Miranda VG, François-Moutal L, Madura CL, Khanna M, Khanna R. Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief. Channels (Austin). 2019 Dec;13(1):498-504. doi: 10.1080/19336950.2019.1684608.
3: Pines AR, Sattur MG, Abi-Aad KR, Bendok BR. Edonerpic Maleate: A Promising Pharmacological Agent for Stroke Recovery. Neurosurgery. 2019 Jan 1;84(1):E3-E4. doi: 10.1093/neuros/nyy397. Alzheimer’s Disease Cooperative Study TCAD Study Group. Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial. JAMA Neurol. 2019 Nov 1;76(11):1330-1339. doi: 10.1001/jamaneurol.2019.1868.

合成参考文献

参考文献:10.14283/jpad.2022.129
摘要:16th Clinical Trials on Alzheimer's Disease (CTAD) Boston, MA (USA) October 24–27, 2023: Symposia. The Journal of Prevention of Alzheimer's Disease. 2023 Nov;10():4–55. doi: 10.14283/jpad.2022.129.
参考文献:10.1007/978-1-0716-4494-2_2
摘要:Takahashi T. Manipulation and Imaging of Plasticity of the Glutamate Synapse for Brain Diseases in Living Human. 2025. In: Neuromethods.