CAS: 48152-09-6; 1,3-Dimorpholinopropane

该化合物是有机化合物,其特点是由丙烷基链链连接的双光伏功能组;甲硫磷是六人组成的含氮和氧的热循环性环球,它有助于化合物的独特特性.这种物质一般在极地溶剂中表现出良好的溶解性,因为有模光环的存在,因此在各种化学应用中有用,包括作为潜在的表面活性剂或聚合化学.丙烷基链接的存在提供了灵活性,能够影响化合物的再活性和与其他分子的相互作用.此外,氨基可参与氢联结,增强化合物在协调化学中作为离子和离子的潜力.

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123-00-2 62478-44-8 915921-49-2

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CAS号110-91-8 吗啉 | CAS号109-64-8 1,3-二溴丙烷

合成工艺路线路线简述

    📜3-(4-吗啉基)丙腈置于sodium Tetrahydroborate,氢气,Nickel Dichloride体系中,用 异丙醇 作为反应溶剂,70.0 °C,101.33 Kpa 条件下,反应 14.0H,以50%的收率获得产物4,4'-(丙烷-1,3-二基)二吗啉
    参考文献:Colloid And Nanosized Catalysts In Organic Synthesis: Xii. Hydrogenation Of Carbonitriles Catalyzed By Nickel Nanoparticles
    标题:Colloid And Nanosized Catalysts In Organic Synthesis: Xii. Hydrogenation Of Carbonitriles Catalyzed By Nickel Nanoparticles
    摘要:Hydrogenation Of Carbonitriles Catalyzed By Nickel Nanoparticles In Isopropanol Proceeds Under Atmospheric Pressure Of Hydrogen Within 6-15 H To Yield Mainly Secondary Amines. Hydrogenation Of Alpha-Aminonitriles Results In Reductive Decyanation. Beta-Aminonitriles Undergo Hydrogenolysis At The Nitrogen-Carbon Bond.
    DOI:10.1134/s1070363216020110

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    专利信息


    专利号:US-6566359-B1
    优先权日:2002-05-20
    标 题:2,4,6-trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid esters as neuroprotective drugs
    发明人:BAZAN NICHOLAS G; SUNKEL CARLOS; MARCHESELLI VICTOR L; BUILLA-G JULIO
    权利人:UNIV LOUISIANA STATE
    摘要:A new series of derivatives of 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid and their synthesis have been discovered. Surprisingly, by modifying the substituent of the 3-carboxylic acid group, new compounds were produced with high activity as PAF receptor antagonists. These compounds were shown to protect neurons from brain damage that normally occurs in response to stroke and other cerebrovascular diseases. These compounds are also protective against edema generation resulting from traumatic breakdown of the blood-brain barrier. Moreover, these compounds were found to be non-toxic and cytoprotective of cells undergoing oxidative stress that would normally trigger apoptotic cell death; and to have activity as (a) antagonists of an intracellular platelet activating factor ('PAF')-binding site, (b) inhibitors of PAF- and cytokine-mediated c-aminoterminal jun kinase (JNK) and extracellular regulated kinase (ERK), and (c) transcriptional inhibitors of COX-2 expression.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:A. Gero. J. Am. Chem. Soc. 76, 5158, 5159 (1954).
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