CAS: 4277-63-8; Methyl 1H-Pyrrole-1-Carboxylate

该化合物是一种多用途的杂交环酯,通常用作有机合成和制药应用中的关键中间体,其发热环结构和酯功能对制造复杂的分子,特别是开发农用化学品,药品和特殊化学品很有价值.该化合物在核生殖器替代和凝聚反应方面表现出了良好的反应性,促进了将烧碎机流引入目标结构.在标准条件下和与普通溶剂兼容性下,其稳定性增强了其在实验室和工业环境中的效用.产品典型的特点是高纯度,确保合成工作流程的一贯性.由于有机酯特性,正确处理需要标准的实验室预防措施.

结构式图片

相似化合物

5176-27-2 21972-99-6 4277-64-9

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上下游产品

CAS号66893-74-1 1-methoxycarbon... | CAS号124-41-4 甲醇钠 | CAS号107962-24-3 pyrrole-1-carbo... | CAS号56475-80-0 吡咯烷甲基氨基甲酸酯 | CAS号109-97-7 吡咯 | CAS号79-22-1 氯甲酸甲酯 | CAS号21972-99-6 1H-pyrrole-1-ca... | CAS号616-38-6 碳酸二甲酯 | CAS号85684-89-5 1-triphenylmeth... | CAS号153400-52-3 7-Azabicyclo[2.... | CAS号53416-89-0 methyl 3-oxo-8-... | CAS号695182-98-0 8-Azabicyclo[3....

合成工艺路线路线简述

    📜Pyrrole-1-Carboxylic Acid置于盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 0.5H,反应生成 甲基吡咯-1-羧酸酯
    参考文献:Activation And Coupling Of Pyrrole-1-Carboxylic Acid In The Formation Of Pyrrole N-Carbonyl Compounds: Pyrrole-1-Carboxylic Acid Anhydride
    标题:Activation And Coupling Of Pyrrole-1-Carboxylic Acid In The Formation Of Pyrrole N-Carbonyl Compounds: Pyrrole-1-Carboxylic Acid Anhydride
    摘要:
    DOI:10.1021/jo00387A046

    海关参考信息

    专利信息


    专利号:US-5591854-A
    优先权日:1994-10-14
    标 题 :Enantioselective synthesis of seven-membered carbocycles and tropanes
    发明人:DAVIES HUW M L
    权利人:UNIV WAKE FOREST
    摘要:A process of enantioselective synthesis of seven-membered carbocycles in the presence of di-rhodium(II) tetracarboxylate catalysts.

    专利号:WO-9611928-A1
    优先权日:1994-10-14
    标 题:Enantioselective synthesis of seven-membered carbocycles and tropanes

    专利号:US-4056536-A
    优先权日:1976-06-29
    标 题:Pyrrolo[2,1-b][3]benzazepines
    发明人:ATKINSON JOSEPH G; BELANGER PATRICE C; ROONEY CLARENCE S; BRITCHER SUSAN F
    权利人:MERCK & CO INC
    摘要:11H-Pyrrolo[2,1-b][3]benzazepin-11-one and derivatives thereof are generally prepared by Friedel-Crafts ring closure of a N-styrylpyrrole-2-carboxylic acid derivative. They are useful intermediates in the synthesis of skeletal muscle relaxants and tranquilizers such as 11-(3-dimethylaminopropylidene)-2-cyano-11H-pyrrolo[2,1-b][3]benzazepi ne.

    专利号:US-11772063-B2
    优先权日:2018-12-18
    标 题:Method and device for producing saccharides and saccharide arrays
    发明人:LÖFFLER FELIX; MENDE MARCO; EICKELMANN STEPHAN; SEEBERGER PETER H; TSOUKA ALEXANDRA; HEIDEPRIEM JASMIN; PARIS GRIGORI
    权利人:MAX PLANCK GESELLSCHAFT
    摘要:The present invention relates to a method and a device for producing saccharides and saccharide arrays. Said method is particularly useful for the synthesis of saccharides in parallel and of high-density saccharide arrays, such as microarrays, which are required for high-throughput screenings.

    专利号:CA-2202615-A1
    优先权日:1994-10-14
    标题:Enantioselective synthesis of seven-membered carbocycles and tropanes

    专利号:US-2008200475-A1
    优先权日:2005-03-28
    标题:4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors
    发明人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
    权利人:PFIZER
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: (I) wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2a , R x , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Scott, P. J. H., Science of Synthesis Knowledge Updates, (2013) 4, 270.
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