CAS: 38953-41-2; 6-Amino-5-Hydroxypyrimidin-4(3H)-One

该化合物是一个七环有机化合物,其内含氨基和羟基功能组群,其内含一个火林水手架,这种结构具有重要的反应性,使它成为制药和农用化学合成中宝贵的中间体,其双重功能允许多用途衍生,形成复杂的杂交环系统.复合性能在极地溶剂中表现出有利的溶解性,便于其在水中和有机反应条件下使用.在受控环境中的稳定性确保了合成应用的可靠性能.研究人员认为,这种化合物在培养生物活性分子,特别是在核核素侧模拟物和酶抑制剂中发挥作用,其结构模型对于结合互动至关重要.

英文名称6-Amino-5-Hydroxypyrimidin-4(3H)-One
中文名称6-氨基-5-羟基-4(3H)-嘧啶酮
IUPAC名称6-amino-5-hydroxypyrimidin-4(3H)-one
其它别名6-Aminopyrimidine-4,5-Diol; 6-Amino-4,5-Pyrimidinediol; 6-Amino-5-Hydroxy-4(1H)-Pyrimidinone; 6-Amino-5-Hydroxy-4(3H)-Pyrimidinone; 4(1H)-Pyrimidinone, 6-Amino-5-Hydroxy- (9Ci); 4(3H)-Pyrimidinone, 6-Amino-5-Hydroxy-
CAS编号38953-41-2
MFCD编号:MFCD19216223
分子式:C4H5N3O2分子量:127.1
产品CID: 1401696
产品分类医药中间体 → 嘧啶类化合物

相似结构搜索
InChIKey: DUFPUPLYCLGLJA-UHFFFAOYSA-N
InChI=1S/C4H5N3O2/c5-3-2(8)4(9)7-1-6-3/h1,8H,(H3,5,6,7,9)
计算化学: 氢键受体数3.0氢键供体数3.0可旋转键数*

MSDS等安全信息

上下游产品

6-氨基-5-羟基-2-甲基-4(1H)-嘧啶酮 4-Amino-5-Hydroxy-2-Methylpyrimidin-6(1H)-One 36591-61-4

合成工艺路线路线简述

📜5-Hydroxy-6-Phenylazo-3H-Pyrimidin-4-One置于sodium Dithionite体系中,用水作为反应溶剂,以76%的收率获得产物6-氨基-5-羟基-4(3H)-嘧啶酮
参考文献:An Autoxidation Study Of C2 Substituted Pyrimidine Amino Reductones
标题:An Autoxidation Study Of C2 Substituted Pyrimidine Amino Reductones
摘要:Three Pyrimidine Derivatives (8A-C),Differing From Isouramil And Divicine At C2,Have Been Synthesized And Their Autoxidation Rates Measured Spectrophotometrically. The Autoxidation Rates Of All Five Pyrimidines (8A-C,Isouramil And Divicine) Were Correlated With Sigma(+)(P) Values (Rho=-1.28,R(2)=0.949). (C) 2006 Published By Elsevier Ltd.
DOI:10.1016/j.Tet.2006.03.049