CAS: 35065-27-1; 2,2',4,4',5,5'-Hexachloro-1,1'-Biphenyl
该化合物是多氯联苯(PCB)家族的成员,该家族由以其环境持久性和潜在毒性而闻名的合成有机化学品组成,该复合体有六个与联苯结构相连的氯原子,有助于其稳定性和降解抗药性;PCB 153的特点是其疏水性,低挥发性和亲脂性,这有利于其在生物系统和环境中的积累;它主要用于工业应用,包括电气设备,热传输液和电极液;由于其环境持久性,已在各种生态系统中检测到PCB 153,引起人们对其生物累积性以及对人类和野生物的潜在有害健康影响的关切,包括内分泌干扰和致癌性;已经在全球范围内实施管制措施,限制多氯联苯(包括PCB153)的生产和使用,因为其环境和健康风险.
- 英文名称2,2',4,4',5,5'-Hexachloro-1,1'-Biphenyl
- 中文名称2,2',4,4',5,5'-六氯-1,1'-联苯
- IUPAC名称2,2',4,4',5,5'-hexachloro-1,1'-biphenyl
- 其它别名2,2',4,4',5,5'--六氯联苯; 2,2',4,4',5,5'-Hexachlorobiphenyl
- CAS编号35065-27-1
- MFCD编号:MFCD00055535
- EINECS号:621-381-5
- FDA UNII编号:ZRU0C9E32O
- 分子式:C12H4Cl6分子量:360.88
- 产品CID: 1355530
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS08 & GHS09;
注释: Health hazard & Environment - 危险类别特定目标器官毒性-重复接触 类别2
水生急性毒性 类别1
水生慢性毒性 类别1 - 警示词Warning(警告)
- 危险描述H373 |长期或反复接触可能损害器官.
H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响. - 防范说明P260-P273-P391-P501
- 危险等级9
- UN编号3432.0
- 危险品标志F,Xi,N,Xn
- 包装等级Ⅱ
- 安全声明16-26-33-36-61-60-35-62-29-9
- 危险类别码11-36/37/38-50/53-33-67-65-38
- WGK Germany3
欧盟法规
ECHA物质ECHA物质C&L通报上下游产品
CAS号108-86-1 溴苯 | CAS号95-94-3 1,2,4,5-四氯苯 | CAS号7145-82-6 1,2,4-三氯-5-碘苯 | CAS号35065-29-3 2,2',3,4,4',5,5... | CAS号636-30-6 2,4,5-三氯苯胺 | CAS号120-82-1 1,2,4-三氯苯 | CAS号15721-02-5 2,2',5,5'-四氯二苯胺 | CAS号35694-08-7 2,2',3,3',4,4',... | CAS号51207-31-9 2,4,7,8-四氯二苯并呋喃 | CAS号92-52-4 联苯 | CAS号92-51-3 联环己烷 | CAS号771-98-2 1-苯基-1-环己烯 | CAS号827-52-1 环己基苯 | CAS号2051-60-7 2-氯联苯 | CAS号15862-07-4 2,4,5-三氯联苯 | CAS号33284-50-3 2,4-二氯联苯 | CAS号70362-47-9 多氯联苯合成工艺路线路线简述
- 合成目标产物 2,2',4,4',5,5'-Hexachlorobiphenyl 主要起始原料 Bromobenzene And 1,2,4,5-Tetrachlorobenzene
- (文献来源)合成步骤主要原料 Bromobenzene 和 1,2,4,5-Tetrachlorobenzene
📜1-碘-2,4,5-三氯苯置于铜体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应生成2,2',4,4',5,5'-六氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
Doi:10.1016/0045-6535(95)00140-4
海关参考信息
- 2903911000-邻二氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-5243032-A
优先权日:1989-06-22
标题:Preparation of azo pigments with low pcb content by coupling in the presence of olefins
发明人：RIEPER WOLFGANG
权利人:HOECHST AG
摘要:The production which is customary in practice of monoazo compounds based on dichloro- and trichloroanilines or disazo compounds of the chlorinated biphenyl series by conventional coupling methods meets with difficulties in that the resulting pigments are contaminated by traces of polychlorinated biphenyls. n According to the invention, it has now been found that by addition of water-soluble olefins of the type ##STR1## (R =H, alk or Oalk; X =--COOR 1 , --CONHR 2 or --NR 3 COR 4 ) n in the azo coupling, the side reactions which form PCBs can be decidedly suppressed during synthesis of the pigments.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Qamar A, Waheed J, Ghulam Mohyuddin S, Chen ZB, Kang DJ, Li Z, Anthony GH, Gooneratne R, Nie FH, Chen JJ. The Status of Polychlorinated Biphenyls (PCBs) Extract from Zhanjiang Mangrove Sediments and the Effects on Tissue Structure and Inflammatory Cytokines in Zebrafish Liver. Bull Environ Contam Toxicol. 2022 Feb 8. doi: 10.1007/s00128-021-03439-6. Epub ahead of print.
463:152986. doi: 10.1016/j.tox.2021.152986. Epub 2021 Oct 7. 4(1):1129. doi: 10.1038/s42003-021-02626-9.
4: Li J, Jing Y, Liu Y, Ru Y, Ju M, Zhao Y, Li G. Large chromosomal deletions and impaired homologous recombination repairing in HEK293T cells exposed to polychlorinated biphenyl 153. PeerJ. 2021 Jul 28;9:e11816. doi: 10.7717/peerj.11816.
合成参考文献
参考文献:10.1016/j.chemosphere.2010.01.026
摘要:Bustnes JO, Moe B, Herzke D, Hanssen SA, Nordstad T, Sagerup K, Gabrielsen GW, Borgå K. Strongly increasing blood concentrations of lipid-soluble organochlorines in high arctic common eiders during incubation fast. Chemosphere. 2010 Apr;79(3):320–5. doi: 10.1016/j.chemosphere.2010.01.026.
参考文献:10.1016/j.aquatox.2011.06.010
摘要:Berg K, Puntervoll P, Klungsøyr J, Goksøyr A. Brain proteome alterations of Atlantic cod (Gadus morhua) exposed to PCB 153. Aquat Toxicol. 2011 Oct;105(3-4):206–17. doi: 10.1016/j.aquatox.2011.06.010.
参考文献:10.1016/j.aquatox.2011.06.011
摘要:Vicquelin L, Leray-Forget J, Peluhet L, LeMenach K, Deflandre B, Anschutz P, Etcheber H, Morin B, Budzinski H, Cachot J. A new spiked sediment assay using embryos of the Japanese medaka specifically designed for a reliable toxicity assessment of hydrophobic chemicals. Aquat Toxicol. 2011 Oct;105(3-4):235–45. doi: 10.1016/j.aquatox.2011.06.011.
参考文献:10.1530/rep.1.00761
摘要:Pocar P, Nestler D, Risch M, Fischer B. Apoptosis in bovine cumulus-oocyte complexes after exposure to polychlorinated biphenyl mixtures during in vitro maturation. Reproduction. 2005 Dec;130(6):857–68. doi: 10.1530/rep.1.00761.
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