专利号:US-7365197-B2 优先权日:2000-12-29 标题 :Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines 发明人:BERGER DAN MAARTEN; BIRNBERG GARY HAROLD; WANG YANONG 权利人:WYETH CORP 摘要:This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.
专利号:US-2014142279-A1 优先权日:2012-09-13 标 题:Method for peptide synthesis 发明人:LALEZARI IRAJ; LALEZARI PARVIZ 权利人:LALEZARI IRAJ; LALEZARI PARVIZ 摘要:A new method based on the synthesis and use of novel N and C protecting agents. The new N-protecting agent, here referred to as V-Phenol, generates V-protected amino acids and can be successfully applied to all conventional peptide bond formations including active esters, N,N′-dicyclohexylcarbodiimide (DCC) or related dehydrating agents mixed anhydride methods, PC13 and related agents. The new C-protecting agent, here referred to as HONE, can be successfully applied to peptide synthesis as an active ester not only in combination with V-protected amino acids but also with other N-protecting agents such as Cbz, Boc, Fmoc, etc.
专利号:US-7825149-B2 优先权日:2006-01-19 标 题 :Substituted imidazoles 发明人:CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE 权利人:PFIZER LTD 摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.
参考文献:10.1186/s12906-023-04016-6 摘要:Thongsom S, Racha S, Petsri K, Ei ZZ, Visuttijai K, Moriue S, Yokoya M, Chanvorachote P. Structural modification of resveratrol analogue exhibits anticancer activity against lung cancer stem cells via suppression of Akt signaling pathway. BMC Complement Med Ther. 2023 Jun 03;23(1):183.