CAS: 266360-42-3; (S)-2-Amino-3-(2,3-Difluorophenyl)Propanoic Acid

该化合物是一种氟化苯麻黄碱衍生物,可能用于药物研究和非对称合成,其个性结构以α碳为主(S)配置,对设计基于丙二酸的治疗器或酶抑制剂很有价值,2,3-二氟苯基双能会增强代谢稳定性和影响生物活性化合物的结合性.这种非天然氨基磺酸是药用化学的多用途构件,特别是在开发有针对性的疗法方面.其高纯度和明确界定的立体化学确保研究应用的再生性.该化合物独特的电子特性由二氟替代所赋予,还可能促进药物发现方案的结构-活动关系研究.

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1260605-30-8 236754-62-4 266360-59-2

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CAS号266360-47-8 2-acetamido-3-(... | CAS号113211-94-2 2,3-二氟苄基溴 | CAS号266360-43-4 diethyl 2-aceta...

合成工艺路线路线简述

    📜2,3-二氟溴苄置于sodium Hydroxide,Aspergillus Genus Acylase,Sodium Ethanolate,Sodium Acetate体系中,用 甲醇,乙醇,对二甲苯,水 用作溶剂,化学反应 55.0H,反应生成L-2,3-二氟苯丙氨酸
    参考文献:Synthesis Of A Complete Set Of L-Difluorophenylalanines,L-(F2)Phe,As Molecular Explorers For The Ch/π Interaction Between Peptide Ligand And Receptor
    标题:Synthesis Of A Complete Set Of L-Difluorophenylalanines,L-(F2)Phe,As Molecular Explorers For The Ch/π Interaction Between Peptide Ligand And Receptor
    摘要:A Complete Set Of Difluorophenylalanines In The L-Configuration [l-(F-2)Phe] (Namely,L-(2,3-F-2)Phe,L-(2,4F(2))Phe,L-(2,5-F-2)Phe,L-(2,6-F-2)Phe,L-(3,4-F-2)Phe,L-(3,5-F-2)Phe) Was Prepared And Incorporated Into The Thrombin Receptor-Tethered Ligand Peptide Sfllrnp To Identify The Phenyl Hydrogens Of The Phe-2 Residue Involved In The Ch/pi Receptor Interaction. (C) 2000 Elsevier Science Ltd. All Rights Reserved.
    Doi:10.1016/s0040-4039(99)02191-7

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    专利信息


    专利号:US-9206222-B2
    优先权日:2009-06-29
    标题:Solid phase peptide synthesis of peptide alcohols
    发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
    权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
    摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.

    专利号:US-8546533-B2
    优先权日:2008-08-29
    标 题:Pipecolic linker and its use for chemistry on solid support
    发明人：MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES
    权利人:MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER 1; UNIV JAGELLONE; UNIV MONTPELLIER II
    摘要:The present invention relates to a pipecolic linker and its use as a solid-phase linker in organic synthesis. Said pipecolic solid-phase linker may be used for coupling functional groups chosen between primary amines, secondary amines, aromatic amines, alcohols, phenols and thiols. In particular, said pipecolic solid-phase linker may be used for peptide or pseudopeptide synthesis, such as the reverse N to C peptide synthesis or the retro-inverso peptide synthesis, or for the synthesis of small organic molecules.

    专利号:WO-2011000848-A1
    优先权日:2009-06-29
    标题 :Solid phase peptide synthesis of peptide alcohols

    专利号:US-2012108748-A1
    优先权日:2009-06-29
    标 题:Solid phase peptide synthesis of peptide alcohols

    专利号:EP-2448956-B1
    优先权日:2009-06-29
    标题:Solid phase peptide synthesis of peptide alcohols

    专利号:EP-2270025-A1
    优先权日:2009-06-29
    标题 :Solid phase peptide synthesis of peptide alcohols

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    参考DOI号:10.1016/S0040-4039(99)02191-7
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