CAS: 23076-35-9; Xylazine Hydrochloride

赛拉嗪置于盐酸体系中,用 甲醇 用作溶剂,以92.9 %的收率获得盐酸甲苯噻嗪
参考文献:一种盐酸二甲苯胺噻嗪的制备方法
标题:一种盐酸二甲苯胺噻嗪的制备方法
摘要:本发明公开了一种盐酸二甲苯胺噻嗪的制备方法,按照先后顺序包括以下步骤:将化合物1经过乙酰化得到化合物2,在反应的过程中加入乙酸酐等;将上述步骤得到的化合物2先与氢化钠反应,再与二硫化碳反应生成化合物3;化合物3再与化合物反应,得到化合物5;化合物5在盐酸的作用下环化得到化合物6;化合物6成盐得到盐酸二甲苯胺噻嗪.本专利方法提高了操作的便利性,收率以及产品纯度得到极大提高,总体成本大大降低.

专利信息

专利号:US-9662347-B2
优先权日:2010-05-11
标题 :Method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of age-albumin in cells of the mononuclear phagocyte system
发明人：LEE BONG HEE; BYUN KYUNG HEE
权利人:LEE BONG HEE; BYUN KYUNG HEE; GACHON UNIV OF INDUSTRY-ACADEMIC COOP FOUND
摘要:The present invention relates to a method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of AGE-albumin in cells of the mononuclear phagocyte system, to an AGE-albumin synthesis inhibitor, and to a pharmaceutical composition comprising the AGE-albumin synthesis inhibitor for preventing or treating degenerative disease and autoimmune disease. The AGE-albumin of the present invention is synthesized and secreted in human microglia or human macrophages in an Alzheimer's model, stroke model, Parkinson's disease model and rheumatoid arthritis model. The AGE-albumin synthesis and secretion are caused by oxidative stress. The expression of RAGE increases in first-order human neurons or cartilage cells to which AGE-albumin is administered, whereupon a MAPK signaling pathway is activated and the expression of Bax increases to induce an increase in calcium in mitochondria, thus finally inducing cell death. Therefore, the AGE-albumin synthesis inhibitor of the present invention can be valuably used in the diagnosis or treatment of degenerative diseases or autoimmune diseases such as Alzheimer's disease, strokes, Parkinson's disease, amyotrophic lateral sclerosis, rheumatoid arthritis, diabetic retinopathy, AIDS, aging, pulmonary fibrosis, spinal cord injuries, etc.

专利号:US-4923851-A
优先权日:1987-12-29
标 题:Composition of matter for increasing intracellular ATP levels and physical performance levels and for increasing the rate of wound repair
发明人：CARNIGLIA FRANCIS J
权利人:RONCARI RAYMOND A
摘要:A composition of matter for increasing the intracellular synthesis of ATP. The composition consists of amino acids, metabolites, electrolyte and a pentose sugar. When applied to wounds, the invention increases the rate of wound repair. When administered orally, the invention increases ATP blood levels and physical performance levels.

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:US-5391550-A
优先权日:1987-12-29
标题 :Compositions of matter and methods for increasing intracellular ATP levels and physical performance levels and for increasing the rate of wound repair
发明人：CARNIGLIA FRANCIS J; KENYON ALAN J
权利人:RONCARI RAYMOND A
摘要:Disclosed are methods and compositions of matter for increasing the intracellular synthesis of ATP. The compositions comprise amino acids, metabolites, electrolyte and/or a pentose sugar. When applied to wounds, the invention increases the rate of wound repair and has a antimicrobial effect. When administered orally, the invention increases ATP blood levels and physical performance levels.

专利号:US-8026215-B2
优先权日:2004-04-30
标题 :Methods and compositions for control of fetal growth via modulation of relaxin
发明人：UNEMORI ELAINE
权利人:CORTHERA INC
摘要:The invention relates to the method for treatment, diagnosis and prevention of diseases related to fetal growth and placental insufficiency and comprises methods including inhibiting or increasing relaxin synthesis, relaxin receptor synthesis, relaxin binding to the relaxin receptor, and relaxin receptor activity. The invention also relates to screening assays to identify compounds that modulate relaxin and/or relaxin receptor activity. The invention further relates to gene therapy methods utilizing relaxin and relaxin-related sequences for the treatment and prevention of diseases related to fetal growth and placental insufficiency.

专利号:US-2004102389-A1
优先权日:1995-10-26
标题 :Nucleic acid-mediated treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
发明人：PAVCO PAMELA; MCSWIGGEN JAMES; STINCHCOMB DAN; ESCOBEDO JAIME; KIM JULIAN; LINDNER DANIEL
权利人:RIBOZYME PHARM INC
摘要:The present invention relates to nucleic acid molecules such as ribozymes, DNAzymes, short interfering RNA (siRNA), short interfering nuleic acid (siNA), and antisense which modulate the synthesis, expression and/or stability of an mRNA encoding one or more receptors of vascular endothelial growth factor, such as flt-1 (VEGFR1) and/or KDR (VEGFR2). Nucleic acid molecules and methods for the inhibition of angiogenesis and treatment of cancer and other conditions associated with VEGF-R are provided, optionally in conjunction with other therapeutic agents such as interferons.