CAS: 18725-37-6; (R)-2-Acetamido-3-(Acetylthio)Propanoic Acid

该化合物是一种具有异硫酯功能组的手性N-乙基乙基氨酸衍生物,其立体特性(R)配置可确保高对应纯度,使其对非对称合成和peptide变异的应用具有价值.乙基硫酸为基于硫醇的同化提供了回动性,允许在生物合成或药物运载系统中选择性地衍生.该化合物是药用化学的多用途中间体,特别是用于设计针对cysteine protise的药物或酶抑制剂.在受控条件下的稳定性和与标准混合试剂的兼容性加强了其在固相聚聚物合成中的效用.分子结构也为研究含硫氨酸的代谢途径提供了机会.

结构式图片

上下游产品

CAS号52-89-1 L-半胱氨酸盐酸盐(无水物) | CAS号108-24-7 乙酸酐 | CAS号52-90-4 L-半胱氨酸 | CAS号1078-38-2 (N)1-acetylisoniazid

合成工艺路线路线简述

    📜N,S-Diacetyl-Cysteine置于马钱子碱体系中,化学反应生成达西司坦
    参考文献:Arnstein; Grant,Biochemical Journal,1954,Vol. 57,P. 360,363
    标题:Arnstein; Grant,Biochemical Journal,1954,Vol. 57,P. 360,363

    海关参考信息

    专利信息


    专利号:US-2008081082-A1
    优先权日:2000-11-21
    标题:Topical Skin Compositions, Their Preparation, and Their Use
    发明人:ZIMMERMAN AMY C; DEPPA DEBRA J; O'TOOLE DEBORAH A; MAYNE JAMES R
    权利人:ACCESS BUSINES GROUP INTERNAT
    摘要:Topical skin compositions include a complex containing components to provide a defense against the various pathway mechanisms of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. The compositions may be administered by topically applying them in an amount to inhibit those mechanisms. The compositions and methods are directed to the prevention of the adverse or detrimental effects of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. Thus, the compositions according to the invention improve barrier function, inhibit elastase and collagenase, and/or promote synthesis of collagen and elastin.

    专利号:US-6160128-A
    优先权日:1997-12-22
    标题:Tritioacetylating reagents and processes for preparation thereof
    发明人:SALJOUGHIAN MANOUCHEHR; MORIMOTO HIROMI; WILLIAMS PHILIP G; THAN CHIT
    权利人:UNIV CALIFORNIA
    摘要:Novel acetylating and tritioacetylating reagents suitable for preparation of nonlabelled and radiolabelled organic compounds. N-acetoxynaphthalimide, N-tritioacetoxyphthalimide, N-tritioacetoxysuccinimide, N-tritioacetoxynaphthalimide and processes of their preparation. The invention also concerns synthesis of nonlabelled acetylated and tritioacetylated organic compounds from precursors containing a free --NH 2 , --SH or --OH group.

    专利号:US-2008124409-A1
    优先权日:2000-11-21
    标题 :Topical Skin Compositions, Their Preparation, and Their Use
    发明人:ZIMMERMAN AMY C; DEPPA DEBRA J; O'TOOLE DEBORAH A; MAYNE JAMES R
    权利人:ACCESS BUSINESS GROUP INT LLC
    摘要:Topical skin compositions include a complex containing components to provide a defense against the various pathway mechanisms of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. The compositions may be administered by topically applying them in an amount to inhibit those mechanisms. The compositions and methods are directed to the prevention of the adverse or detrimental effects of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. Thus, the compositions according to the invention improve barrier function, inhibit elastase and collagenase, and/or promote synthesis of collagen and elastin.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Shibuya N, Koike S, Tanaka M, Ishigami-Yuasa M, Kimura Y, Ogasawara Y, Fukui K, Nagahara N, Kimura H. A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells. Nat Commun. 2013;4:1366. doi: 10.1038/ncomms2371. doi: 10.1038/ejcn.2014.114. Epub 2014 Jun 25.
    3: Yamane S, Nomura R, Yanagihara M, Nakamura H, Fujino H, Matsumoto K, Horie S, Murayama T. L-Cysteine/D,L-homocysteine-regulated ileum motility via system L and B°(,+) transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments. Eur J Pharmacol. 2015 Oct 5;764:471-9. doi: 10.1016/j.ejphar.2015.07.042. Epub 2015 Jul 19. doi: 10.1007/s00726-014-1899-4. Epub 2014 Dec 23. doi: 10.1016/j.amjsurg.2014.11.014. Epub 2015 Mar 27. doi: 10.1007/978-3-319-18440-1_10. doi: 10.1021/bi401397g. Epub 2014 Feb 5.
    8: Ishiwata S, Ogata S, Umino A, Shiraku H, Ohashi Y, Kajii Y, Nishikawa T. Increasing effects of S-methyl-L-cysteine on the extracellular D-serine concentrations in the rat medial frontal cortex. Amino Acids. 2013 May;44(5):1391-5. doi: 10.1007/s00726-013-1464-6. Epub 2013 Feb 17. doi: 10.1002/jnr.23772. Epub 2016 Jun 14. Epub 2001 Aug 29. doi: 10.1095/biolreprod.114.125443. Epub 2015 Feb 25. doi: 10.3945/ajcn.113.062729. Epub 2014 Mar 5.

    合成参考文献


    参考文献:10.1007/978-3-658-07310-7_4
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