CAS: 1548-13-6; 4-(Trifluoromethyl)Phenylisocyanate

相似化合物

16588-74-2 2285-12-3 1645-65-4

上下游产品

CAS号455-14-1 4-氨基三氟甲苯 | CAS号32315-10-9 三光气 | CAS号709-66-0 para-(trichloro... | CAS号455-24-3 4-三氟甲基苯甲酸 | CAS号503-38-8 氯甲酸三氯甲酯 | CAS号75-44-5 光气 | CAS号1891-90-3 4-(三氟甲基)苯甲酰胺 | CAS号917-61-3 氰酸钠 | CAS号98-56-6 4-氯三氟甲苯 | CAS号90774-69-9 4-(三氟甲基)苯胺盐酸盐 | CAS号23779-14-8 Phenyl [4-(trif... | CAS号23794-73-2 (4-(三氟甲基)苯基)氨基甲酸乙酯 | CAS号23745-45-1 Carbanilic acid... | CAS号350-98-1 N-[4-(Trifluoro... | CAS号162748-21-2 1-[4-(trifluoro... | CAS号7159-99-1 1,1-dimethyl-3-... | CAS号3824-74-6 1,3-双(3,5-双(三氟甲...

4-三氟甲基苯甲酸置于叠氮磷酸二苯酯,三乙胺体系中,用 苯 用作溶剂,化学反应 2.75H,反应生成4-三氟甲基苯基异氰酸酯
参考文献:基于四氢异喹啉的二芳基尿素衍生物的设计,合成和生物学评估,用于抑制vegfr-2信号传导.
标题:基于四氢异喹啉的二芳基尿素衍生物的设计,合成和生物学评估,用于抑制vegfr-2信号传导.
摘要:结合二芳基脲部分的新型基于四氢异喹啉的化合物的结构系列被设计,合成,并通过生物学方法评估为vefgr-2信号的抑制剂.结果,化合物9K和9S对吉非替尼对被测试的三种细胞系,包括a549,Mcf-7和pc-3,表现出与吉非替尼相当或更高的细胞毒性.重要的是,它们两个都下调了vegfr-2的表达,并以0.5或1.0μmol/ L的浓度抑制了vegfr-2的磷酸化.此外,它们以4.0μmol/ L的浓度抑制人脐静脉内皮细胞管的形成.考虑到它们下调vegfr-2表达和抑制vegfr-2磷酸化的能力,9K和9S可以作为血管生成的抑制剂,以供进一步研究.
Doi:10.1097/cad.0000000000000718

专利信息

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-9879050-B2
优先权日:2013-08-30
标 题 :Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase
发明人：LEE RICHARD E; ZHAO YING; GRIFFITH ELIZABETH; ZHENG ZHONG; SINGH AMAN P
权利人:ST JUDE CHILDREN'S RES HOSPITAL
摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-2010286211-A1
优先权日:2004-10-08
标题:Oxazolidinone derivatives as antimicrobials
发明人：DAS BISWAJIT; AHMED SHAHADAL; YADAV AJAY SINGH; GHOSH SOMA; GUJRATI ARTI; SHARMA PANKAJ; RATTAN ASHOK
权利人:DAS BISWAJIT; AHMED SHAHADAL; YADAV AJAY SINGH; GHOSH SOMA; GUJRATI ARTI; SHARMA PANKAJ; RATTAN ASHOK
摘要:The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, for example, multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, for example, Bacterioides spp. and Clostridia spp. species, and acid fast organisms, for example, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

专利号:CN-111471171-B
优先权日:2019-01-24
标 题:A kind of aryl sulfonic acid intermediate and its preparation method, and its application for the synthesis of low temperature sensitive admixture for concrete

专利号:US-10822377-B2
优先权日:2015-03-04
标 题:Substituted urea depsipeptide analogs as activators of the ClpP endopeptidase
发明人：LEE RICHARD E; ZHAO YING; JIUYU LIU
权利人:ST JUDE CHILDRENS RES HOSPITAL
摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.