CAS: 133116-83-3; 2-Fluoro-6-(Trifluoromethyl)Benzonitrile

相似化合物

32890-94-1 60611-24-7 261951-81-9

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CAS号133116-84-4 5-Trifluorometh... | CAS号239087-06-0 2-氟-6-(三氟甲基)苄胺

3-氯-2-氰基三氟甲苯置于potassium Fluoride体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应生成2-氟-6-(三氟甲基)苯腈
参考文献:一种2-氰基-3-氟三氟甲苯的制备方法
标题:一种2-氰基-3-氟三氟甲苯的制备方法
摘要:本发明公开了一种2‑氰基‑3‑氟三氟甲苯的制备方法,具体涉及2‑氰基‑3‑氟三氟甲苯制备领域,具体包括以下步骤:步骤一,先将式i所代表的2‑氰基‑3‑氟三氟甲苯和氰化试剂在有机溶剂中反应,得到式ii所代表的中间体化合物;步骤二,将氟化试剂添加到步骤一中制备的式ii所代表的中间体化合物中,进行氟化反应,然后通过浓缩制备出式iii所代表的目标产物.本发明首次实现了由2‑氰基‑3‑氟三氟甲苯与氰化试剂在溶剂中直接反应,所得中间体继续进行氟化反应制备了2‑氰基‑3‑氟三氟甲苯.本发明方法具有反应效率高,原料成本低,可广泛用于邻三氟甲基苯氰类化合物制备的特点,原料成本低廉,操作方便,三废少,利于工业放大生产.

专利信息

专利号:US-11858901-B2
优先权日:2019-10-30
标 题:3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6 trifluoromethyl benzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, process for its preparation, and its use in the synthesis of elagolix
发明人：BALLETTE ROBERTO; JIMÉNEZ ALONSO OSCAR; GARCÃ?A GARCÃ?A ELENA; DOBARRO RODRÃ?GUEZ ALICIA
权利人:MOEHS IBERICA SL
摘要:A new intermediate is useful in the synthesis of elagolix. A process for obtaining the intermediate includes reacting a precursor with iodine monochloride in the presence of an organic solvent. A process for preparing elagolix makes use of the intermediate. The intermediate can be 3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6-trifluoromethylbenzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, such as a hydrochloride.

专利号:US-11840519-B2
优先权日:2019-09-03
标 题 :Process for the synthesis of the sodium salt of 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)-phenyl]methyl]-3,6-dihydro-4-methyl-2.6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]amino]-butanoic acid (elagolix sodium salt) and intermediates of said process
发明人：LENNA ROBERTO; FASANA ANDREA; ORTIZ JERRY
权利人:IND CHIMICA SRL
摘要:The present invention to a process for the preparation of the sodium salt of 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-amino]-butanoic acid, compound also known as Elagolix sodium salt, having the formula (I) reported below:

专利号:US-2022281829-A1
优先权日:2019-09-03
标题 :Process for the synthesis of the sodium salt of 4-[[(1r)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)-phenyl]methyl]-3,6-dihydro-4-methyl-2,6- dioxo-1(2h)-pyrimidinyl]-1- phenylethyl]amino]-butanoic acid (elagolix sodium salt) and intermediates of said process

专利号:WO-2009056955-A1
优先权日:2007-10-30
标题 :Amine-bearing phospholipids (abps), their synthesis and use
发明人：ZUMBUEHL ANDREAS
权利人:UNIV BASEL; ZUMBUEHL ANDREAS
摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

专利号:US-2003120351-A1
优先权日:2001-12-21
标 题:Synthesis of calcium phosphates by mechano-chemical process

专利号:WO-2021044230-A1
优先权日:2019-09-03
标题:Process for the synthesis of the sodium salt of 4-[[(lr)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)-phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-l(2h)-pyrimidinyl]-l- phenylethyl]amino]-butanoic acid (elagolix sodium salt) and intermediates of said process