CAS: 128676-84-6; 2-Chloroquinoline-3-Boronic Acid
该化合物是一种有机化合物,其特征是其碳酸功能组和氯代基quinoline结构,通常是一种固体,在极地有机溶剂中可以溶解.由于存在溴酸组,它能够参与各种化学反应,特别是铃木混合反应,这对合成双aryl化合物至关重要.氯组增强了其再活动性,可以作为核生殖替代反应中的剩余组.这种化合物经常用于医药化学和材料科学中,因为它在药物开发和有机合成中的潜在应用.此外,它可能展示生物活动,使其对药物研究感兴趣.在处理时,应参考安全数据,因为溴酸可能对湿度敏感,可能需要具体的储存条件.
相似化合物
191162-39-7 2377611-57-7 1370040-83-7物理性质
MSDS等安全信息
上下游产品
CAS号128676-94-8 2-氯-3-羟基喹啉 | CAS号116632-54-3 2-氯-3-氨基喹啉 | CAS号78105-37-0 2-氯-3-硝基喹啉合成工艺路线路线简述
📜2-氯喹啉,硼酸三丁酯,水置于仲丁基锂,盐酸体系中,用 四氢呋喃 用作溶剂,化学反应 3.5H,以51%的收率获得2-氯喹啉-3-硼酸
参考文献:一种制备2-氯喹啉-3-硼酸的方法
标题:一种制备2-氯喹啉-3-硼酸的方法
摘要:本申请属于有机化学合成技术领域,特别是涉及一种制备2‑氯喹啉‑3‑硼酸的方法.现有的2‑氯喹啉‑3‑硼酸制备方法比较复杂,浪费人力物力.本申请提供了一种制备2‑氯喹啉‑3‑硼酸的方法,以2‑氯喹啉和硼试剂为原料,在碱作用下发生2‑氯喹啉的3位取代反应,然后在酸作用下水解得到2‑氯喹啉‑3‑硼酸.反应条件温和,后处理纯化简单,收率高,成本低.
海关参考信息
- 2902200000-苯
2933310010-吡啶
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8591878-B2
优先权日:2008-02-25
标 题:Therapeutic compounds
发明人：MCCAULEY JOHN A; LIVERTON NIGEL J; HARPER STEVEN; MCINTYRE CHARLES J; RUDD MICHAEL T
权利人:MCCAULEY JOHN A; LIVERTON NIGEL J; HARPER STEVEN; MCINTYRE CHARLES J; RUDD MICHAEL T; MERCK SHARP & DOHME; ANGELETTI P IST RICHERCHE BIO
摘要:A class of macrocyclic compounds of formula (I), wherein R 1 , R 3 , R 4 , R a , R b , A, B, Z, M, W and n are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection.
专利号:US-9738661-B2
优先权日:2006-10-27
标题:HCV NS3 protease inhibitors
发明人：LIVERTON NIGEL J; SUMMA VINCENZO; HARPER STEVEN; MCCAULEY JOHN A; ROMANO JOSEPH J; RUDD MICHAEL T
权利人:MERCK SHARP & DOHME; MSD ITALIA SRL
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Screening For Covalent Inhibitors Using Dna-Display Of Small Molecule Libraries Functionalized With Cysteine Reactive Moieties作者:C. Zambaldo,J.-P. Daguer,J. Saarbach,S. Barluenga,N. Winssinger
摘要:Despite The Resurging Interest In Covalent Inhibitors, Libraries Are Typically Designed With Synthon Filtered Out For Reactive Functionalities That Can Engage A Target Through Covalent Interactions. Herein, We Report The Synthesis Of Two Libraries Containing Michael Acceptors To Identify Cysteine Reactive Ligands. We Developed A Simple Procedure To Discriminate Between Covalent And High Affinity Non-Covalent
合成参考文献
摘要:Gribble, G. W., Science of Synthesis, (2006) 8, 398.
摘要:Larsen, R. D.; Cai, D., Science of Synthesis, (2005) 15, 472.
📝 需求与反馈
尽可能描述清楚需求与问题信息
