CAS: 87913-26-6; N-(4-Bromophenyl)Adamantan-2-Amine

该化合物是一种属于伊第泽类衍生物类别的化学化合物,其特点是独特的结构,包括溴联苯组和一丁二二二醇,有助于其生物活动;Bromantan已研究其可能用作一种新热带制剂,表现出可增强认知功能和物理性能的特性;此外,已调查其潜在的...

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CAS号106-37-6 对二溴苯 | CAS号13074-39-0 2-金刚烷胺

合成工艺路线路线简述

  • 合成目标产物 Bromantane 主要起始原料 2-Adamantanone And 4-Bromoaniline
  • 106-37-6 + 13074-39-0 = 87913-26-6
    反应条件:1.1 Reagents: Sodium Tert-Butoxide Catalysts: Bis(Dibenzylideneacetone)Palladium,Binap Solvents: 1,4-Dioxane; 7 H,Reflux
    标题:Palladium-Catalyzed Amination Of Isomeric Dihalobenzenes With 1- And 2-Aminoadamantanes
    作者:Averin,A. D.; Et Al
    参考文献:Russian Journal Of Organic Chemistry 日期:2010 卷标:46(1) 页码:64-72]

    700-58-3 = 87913-26-6
    反应条件:1.1 Reagents: 1,3,5-Trioxane,Hydrochloric Acid
    标题:N-Adamantyl Derivatives Of Aromatic Amines. I. Synthesis And Neurotropic Activity Of N-(Adamant-2-Yl)Anilines
    作者:Morozov,I. S.; Et Al
    参考文献:Khimiko-Farmatsevticheskii Zhurnal 日期:1998 卷标:32(1) 页码:3-6]

    700-58-3 = 87913-26-6
    反应条件:1.1 Reagents: Carbon Monoxide Catalysts: Ruthenium Trichloride Solvents: Acetonitrile; 11 H,30 Atm,140 °C
    标题:Ruthenium-Catalyzed Reductive Amination Without An External Hydrogen Source
    作者:Kolesnikov,Pavel N.; Et Al
    参考文献:Organic Letters 日期:2015 卷标:17(2) 页码:173-175]

    106-37-6 + 13074-39-0 = 87913-26-6 + 700-58-3
    反应条件:1.1 Reagents: Sodium Tert-Butoxide Catalysts: Bis(Dibenzylideneacetone)Palladium,1,1′-(9,9-Dimethyl-9H-Xanthene-4,5-Diyl)Bis[1,1-Diphenylphosphine] Solvents: 1,4-Dioxane; 7 H,Reflux
    标题:Palladium-Catalyzed Amination Of Isomeric Dihalobenzenes With 1- And 2-Aminoadamantanes
    作者:Averin,A. D.; Et Al
    参考文献:Russian Journal Of Organic Chemistry 日期:2010 卷标:46(1) 页码:64-72]

    106-37-6 + 13074-39-0 = 87913-26-6 + 52917-67-6
    反应条件:1.1 Reagents: Sodium Tert-Butoxide Catalysts: Bis(Dibenzylideneacetone)Palladium,2′-(Dicyclohexylphosphino)-N,N-Dimethyl[1,1′-Biphenyl]-2-Amine Solvents: 1,4-Dioxane; 7 H,Reflux
    标题:Palladium-Catalyzed Amination Of Isomeric Dihalobenzenes With 1- And 2-Aminoadamantanes
    作者:Averin,A. D.; Et Al
    参考文献:Russian Journal Of Organic Chemistry 日期:2010 卷标:46(1) 页码:64-72
📜金刚烷酮,4-溴苯胺置于dirhodium Tetraacetate,一氧化碳体系中,用 四氢呋喃 作为反应溶剂,以85 %的收率获得产物布罗曼坦
参考文献:催化利用转炉煤气--一种用于合成药物的工业废料
标题:催化利用转炉煤气--一种用于合成药物的工业废料
摘要:转炉煤气是一种大型废品,通常燃烧成二氧化碳并导致全球温室气体排放.在本文中,我们证明转化器气体可以代替燃烧,用作有机反应中的还原剂,以生产有价值的药物和农用化学品.特别地,基于酰胺的选定药物分子已经通过芳族硝基化合物和羧酸在转炉气体存在下的反应合成.此外,我们还证明了这种气体也可以方便地用于进行经典的还原胺化反应.
DOI:10.1039/d3Sc00257H

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主要参考文献

参考标题:Ruthenium-Catalyzed Reductive Amination Without An External Hydrogen Source
作者:Pavel N. Kolesnikov,Niyaz Z. Yagafarov,Dmitry L. Usanov,Victor I. Maleev,Denis Chusov |发布日期:2015.1.16
摘要:A Ruthenium-Catalyzed Reductive Amination Without An External Hydrogen Source Has Been Developed Using Carbon Monoxide As The Reductant And Ruthenium(III) Chloride (0.008-2 Mol %) As The Catalyst. The Method Was Applied To The Synthesis Of Antianxiety Agent Ladasten.

合成参考文献


摘要:Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology., 62(2)(3), 1999
摘要:Sedov AV, Surovtsev NA, Lukicheva TA, Beliakova IP. [Tactics of protection of humans in accidents associated with combined exposure to chemical and physical factors]. Med Tr Prom Ekol. 1999;(12):34–7.
参考文献:10.1023/a:1016206306875
摘要:Iezhitsa IN, Spasov AA, Bugaeva LI, Morozov IS. Toxic Effect of Single Treatment with Bromantane on Neurological Status of Experimental Animals. Bulletin of Experimental Biology and Medicine. 2002 Apr;133(4):380–3. doi: 10.1023/a:1016206306875.
摘要:Vakhitova IuV, Sadovnikov SV, Iamidanov RS, Seredenin SB. [Cytosine demethylation in the tyrosine hydroxylase gene promoter in the hypothalamus cells of the rat brain under the action of an aminoadamantane derivative Ladasten]. Genetika. 2006 Jul;42(7):968–75.
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