CAS: 84859-27-8; 5-Chloro-N1-Methylbenzene-1,2-Diamine

该化合物是一种替代芳烃二胺,在苯环的N1位置有一组氯,在苯环的N1位置有一组甲基氨基,该化合物是有机合成的多用途中间体,特别是用于制作三环化合物,染料和药剂,其结构特征,包括电提取氯替代物和甲基氨基功能,加强了电益替代和凝聚反应中的再活动.该化合物因其稳定性和在受控条件下参与选择性功能化的能力而受到重视,使其在化学和农用化学的细微应用中有用.由于氧化的潜在敏感性,需要适当处理.

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4-chloro-2-methylaminonitrobenzene hydrogenchloride 3,4-dinitro-chlorobenzene 2,4-dichloronitrobenzene acetic acid-[2-(6-chloro-4-methyl-3-oxo-3,4-dihydro-quinoxalin-2-yl)-anilide] 1-methyl-6-chloro-1H-benzo[d]imidazole H-benzimidazol-2-yl)-methanol(6-chloro-1-methyl-1H-benzimidazol-2-yl)-methanol 6-Chloro-1-methyl-2-p-tolyl-1H-benzoimidazole

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  • 35966-84-8 = 84859-27-8
    反应条件:1.1 Reagents: Iron Solvents: Acetic Acid; 100 °C
    标题:Discovery Of A 1,5-Dihydrobenzo[b][1,4]Diazepine-2,4-Dione Series Of Inhibitors Of Hiv-1 Capsid Assembly
    作者:Fader,Lee D.; Bethell,Richard; Bonneau,Pierre; Boes,Michael; Bousquet,Yves; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2011 卷标:21(1) 页码:398-404]

    35966-84-8 = 84859-27-8
    反应条件:1.1 Reagents: Stannous Chloride Solvents: Ethyl Acetate; 16 H,Reflux
    标题:Discovery Of Selective Fragment-Sized Immunoproteasome Inhibitors
    作者:Kollar,Levente; Gobec,Martina; Szilagyi,Bence; Proj,Matic; Knez,Damijan; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2021 卷标:219]

    35966-84-8 = 84859-27-8
    反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Tetrahydrofuran
    标题:Synthesis And Antiparasitic Activity Of 2-(Trifluoromethyl)Benzimidazole Derivatives
    作者:Navarrete-Vazquez,G.; Cedillo,R.; Hernandez-Campos,A.; Yepez,L.; Hernandez-Luis,F.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2001 卷标:11(2) 页码:187-190
📜2,4-二氯硝基苯置于氢气,铜体系中,用 乙醇,水 作为反应溶剂,20.0~100.0 °C,101.33 Kpa 条件下,反应 11.0H,反应生成 5-氯-N1-甲基苯-1,2-二胺
参考文献:Discovery Of 2-Iminobenzimidazoles As Potent Hepatitis C Virus Inhibitors With A Novel Mechanism Of Action
标题:Discovery Of 2-Iminobenzimidazoles As Potent Hepatitis C Virus Inhibitors With A Novel Mechanism Of Action
摘要:In This Report We Describe 2-Iminobenzimidazole (Ibi) Analogs,Identified During The Course Of A Phenotypic High-Throughput Screening Campaign,As Novel Hepatitis C Virus (Hcv) Inhibitors. A Series Of Ibi Derivatives Was Synthesized And Evaluated For Their Inhibitory Activity Against Infectious Hcv. Among The Ibis Derivatives Studied In This Work,We Identified Promising Compounds With High Antiviral Efficacy,High Selectivity Index And Good Microsomal Stability. Noteworthy,The Ibi Series Exhibited Inhibitory Activity On Early And Late Steps Of The Viral Cycle,But Not In The Hcv Replicon System Demonstrating A Mechanism Of Action Distinct From Clinical-Stage And Approved Anti-Hcv Drugs. Overall,Our Results Suggest That Ibis Are Predestinated For Further Exploration As Lead Compounds For Novel Hcv Interventions. (C) 2014 Elsevier Masson Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2014.03.030

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摘要:Tomé, A. C., Science of Synthesis, (2004) 13, 540.
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