CAS: 36052-27-4; Methyl 3-Aminopicolinate

相似化合物

912369-42-7 1462-86-8 52378-63-9

上下游产品

CAS号67-56-1 甲醇 | CAS号1462-86-8 3-氨基吡啶-2-羧酸 | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号912369-42-7 3-(B°C-氨基)吡啶甲酸甲酯 | CAS号186581-53-3 重氮甲烷 | CAS号4664-00-0 2,3-吡啶二甲酰亚胺 | CAS号89-00-9 吡啶-2,3-二羧酸 | CAS号866775-09-9 3-氨基-6-溴吡啶-2-甲酸甲酯

2,3-吡啶二酰亚胺置于sodium Hydroxide,Sodium Hypobromide体系中,用 甲醇 用作溶剂,化学反应 2.5H,反应生成3-氨基吡啶-2-羧酸甲酯
参考文献:3-芳基-4-羟基喹啉-2(1H)-作为nmda /甘氨酸部位拮抗剂的5-,6-,7-和8-氮杂类似物的合成和sar.
标题:3-芳基-4-羟基喹啉-2(1H)-作为nmda /甘氨酸部位拮抗剂的5-,6-,7-和8-氮杂类似物的合成和sar.
摘要:合成了3-芳基-4-羟基喹啉-2(1H)-One的一系列5-,6-,7-和8-氮杂类似物,并测定为nmda /甘氨酸受体拮抗剂.这些拮抗剂的体外效能是通过在大鼠大脑皮膜中置换甘氨酸位点放射性配体[[(3)h] 5,7-Dicholorokynurenic酸([(3)h] Dcka)确定的.还使用表达克隆的nmda受体(nr)1A / 2C亚基的非洲爪蟾卵母细胞中的电生理测定法测试了所选化合物的功能拮抗作用.在研究的5,6,7,8氮杂-3-芳基-4-羟基喹啉2(1H)-中,5-氮杂7-氯-4-羟基-3-(3-苯氧基苯基) )quinolin-2-(1H)-One(13I)是最有效的拮抗剂,在[(3)h] Dcka结合中的ic(50)值为110 Nm,在电生理学中的k(b)为11 Nm分析.
Doi:10.1016/s0968-0896(01)00115-8

专利信息

专利号:US-2025304580-A1
优先权日:2021-11-09
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-2022315528-A1
优先权日:2019-08-21
标题:Inhibitors of phospholipid synthesis and methods of use
发明人：GOUW ARVIN; SCHOW STEVEN R; GREENHOUSE ROBERT J; KLINE TONI; FELSHER DEAN W
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome, hyperlipidemia, infection and inflammation.

专利号:WO-2021035031-A1
优先权日:2019-08-21
标 题 :Inhibitors of phospholipid synthesis and methods of use

专利号:CN-109608441-A
优先权日:2018-12-26
标题:A kind of synthesis process of ASK1 inhibitor

专利号:CN-116947864-A
优先权日:2023-07-07
标题 :Synthesis method of 6-substituted indolinone compound

专利号:IT-8224576-A1
优先权日:1982-12-03
标题 :New derivatives of aminopyridincarboxylic acids, their synthesis methods and pharmaceutical compositions containing them