CAS: 3279-95-6; 2-(Aminooxy)Ethanol

该化合物是一种多功能双功能化合物,具有氨基氧基和氢氧基化合物,对交融化学和交叉结合应用很有价值.氨基氧混合物能够有效地用甲状腺和甲酮进行氧化解扎,而氢氧混合物为进一步功能化提供额外的再活性.该化合物在生物融合,聚合合成和改良生物分子的准备方面特别有用.在温和条件下,水溶性和稳定性增强了其在水下反应环境中的效用. 药物研究,材料科学和生物化学实验通常使用乙醇,需要选择性和高效的混合反应.

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相似化合物

1023742-13-3 23156-68-5 82172-73-4

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CAS号32380-69-1 2-(2-羟基乙氧基)异吲哚啉... | CAS号3279-94-5 (2-hydroxy-etho... | CAS号83495-51-6 2-[(isopropylid... | CAS号23156-61-8 acetaldehyde O-... | CAS号38128-93-7 3-[(2-hydroxy-e...

合成工艺路线路线简述

  • 合成目标产物 2-(Aminooxy)Ethanol 主要起始原料 2-(2-Hydroxyethoxy)Isoindoline-1.3-Dione
  • (文献来源)合成步骤主要原料 2-(2-Hydroxyethoxy)Isoindoline-1.3-Dione
2-[(Isopropylideneamino)Oxy]-Ethanol置于盐酸体系中,化学反应生成2-氨氧基乙醇
参考文献:氨基酸及相关化合物的合成和γ-氨基丁酸转氨酶抑制.
标题:氨基酸及相关化合物的合成和γ-氨基丁酸转氨酶抑制.
摘要:
Doi:10.1021/jm01238A006

海关参考信息

专利信息


专利号:US-6624294-B2
优先权日:1999-01-08
标 题:Regioselective synthesis of 2′-O-modified nucleosides
发明人:KAWASAKI ANDREW M; FRASER ALLISTER S; MANOHARAN MUTHIAH; COOK P DAN; PRAKASH THAZHA P
权利人:ISIS PHARMACEUTICALS INC
摘要:Methods for the regioselective alkylation at the 2'-hydroxy position over the 3'-hydroxy position of nucleosides and nucleoside analogs, forming 2'-O-ester modified compounds, are disclosed. Reduction and derivatization of the 2'-O-ester provides 2'-O-modified nucleosides and nucleoside analogs useful for the synthesis of oligomeric compounds having improved hybridization affinity and nuclease resistance.

专利号:US-8664357-B2
优先权日:2008-08-08
标题 :Solvent resistant diafiltration of peptides, PNA or oligonucleotides
发明人:LIVINGSTON ANDREW GUY; PEEVA LUDMILA GEORGIEVA; SO SHEYUNG WANG JERRY; CAMPOS VASCONCELES RENATO; LEATHERBARROW ROBIN JOHN; TATE EDWARD WILLIAM; GAFFNEY PIERS ROBERT JAMES
权利人:LIVINGSTON ANDREW GUY; PEEVA LUDMILA GEORGIEVA; SO SHEYUNG WANG JERRY; CAMPOS VASCONCELES RENATO; LEATHERBARROW ROBIN JOHN; TATE EDWARD WILLIAM; GAFFNEY PIERS ROBERT JAMES; IMP INNOVATIONS LTD
摘要:According to the present invention, there is provided a process for the preparation of a first compound selected from peptides, oligonucleotides and peptide nucleic acids. The process comprises synthesizing the first compound and then separating the first compound formed in step (i) from a second compound, which is a reaction by-product of the synthesis of the first compound and/or an excess of a reagent used for the synthesis of a first compound by a process of diafiltration. The membrane used for the diafiltration process is stable in organic solvents and provides a rejection for the first compound which is greater than the rejection for the second compound.

专利号:US-4709028-A
优先权日:1987-02-03
标 题 :Synthesis of heterocyclic amines via the reaction of dialkylene glycol and ammonia
发明人:JOHNSON THOMAS A; COOPER CAWAS A
权利人:AIR PROD & CHEM
摘要:This invention relates to an improved process for producing a heterocyclic amine, e.g., morpholine and its derivatives by reacting ammonia and a dialkylene glycol. The improvement resides in adding an inert solvent in the form of an alkyl ether of a polyalkylene glycol with said feed. By including such inert solvent one reduces heavies formation particularly at high conversion.

专利号:US-6774180-B2
优先权日:2000-12-18
标 题:Synthesis of high molecular weight non-peptidic polymer derivatives
发明人:KOZLOWSKI ANTONI; SHEN XIAOMING; BENTLEY MICHAEL DAVID; FANG ZHIHAO
权利人:NEKTAR THERAPEUTICS AL CORP
摘要:High molecular weight derivatives of activated poly(ethylene glycol) and the like polymers are prepared in high purity by conjugating a large PEG molecule to a small PEG molecule. Most of the reaction steps can be accomplished on the more readily purified small molecule to avoid laborious purification of the high molecular weight derivatives.

专利号:US-4996315-A
优先权日:1990-01-16
标 题:Novel synthesis of cyclic compounds
发明人:SPERANZA GEORGE P; LIN JIANG-JEN
权利人:TEXACO CHEMICAL
摘要:Novel cyclic ester-amides having the formula: where R is an alkyl group having from 2 to 5 carbon atoms, and x ranges from 2 to 6 by reacting a polyethylene glycol monoamine having the formula NH2-(CH2CH2O)x-H, where x is as above, with at least one dicarboxylic acid, where the dicarboxylic acid is selected from the group consisting of glutaric, adipic, pimelic acids and mixtures thereof. The a molar ratio of polyethylene glycol monoamine to dicarboxylic acid should be about 1:1. Catalysts may be optionally used, and may include such compounds as titanium alkoxides; and zinc, manganese and antimony salts of carboxylic acids. This method is anticipated to be a useful step in a new preparation of valuable cyclic products.

专利号:US-8796394-B2
优先权日:2009-08-27
标 题 :Antifouling hydrogels, coatings, and methods of synthesis and use thereof
发明人:MESSERSMITH PHILLIP B; RIVERA JOSE; GONG YONG-KUANG
权利人:MESSERSMITH PHILLIP B; RIVERA JOSE; GONG YONG-KUANG; UNIV NORTHWESTERN
摘要:The invention provides an antifouling hydrogel comprising an effective amount of antifouling polymer modified with a compound containing catechol functional groups to yield a modified antifouling polymer comprising at least one catechol functional end group; and an effective amount of at least one oxidizing reagent, wherein the at least one oxidizing reagent reacts with the modified antifouling polymer to provide a modified antifouling polymer comprising at least one oxidized catechol end group, wherein an antifouling hydrogel is provided. Methods of synthesis, methods of use and kits of the antifouling hydrogel are also provided.
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合成参考文献


摘要:Geffken, D.; Köllner, M. A., Science of Synthesis, (2009) 40, 1056.
摘要:Geffken, D.; Köllner, M. A., Science of Synthesis, (2009) 40, 1053.
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