CAS: 31374-18-2; 7-Chloro-4-Hydroxyquinazoline

上下游产品

CAS号5900-59-4 2-氨基-4-氯苯甲酰胺 | CAS号77287-34-4 甲亚胺酸 | CAS号89-77-0 2-氨基-4-氯苯甲酸 | CAS号111-90-0 二乙二醇乙醚 | CAS号942319-20-2 Benzamide, 4-ch... | CAS号463-52-5 formamidine | CAS号5900-58-3 2-氨基-4-氯苯甲酸甲酯 | CAS号122-51-0 原甲酸三乙酯 | CAS号38487-86-4 2-氨基-4-氯苯腈 | CAS号53449-14-2 7-氯-6-硝基喹唑啉-4-酮 | CAS号162012-71-7 4,7-二氯-6-硝基喹唑啉 | CAS号2148-57-4 4,7-二氯喹唑啉

2-氨基-4-氯苯甲酰胺置于盐酸体系中,用 水,原甲酸三甲酯 作为反应溶剂,以77%的收率获得产物7-氯-4(3H)-喹唑啉酮
参考文献:Ep1229025
标题:Ep1229025

专利信息

专利号:US-8188274-B2
优先权日:2006-01-26
标题 :Process for preparing aminocrotonylamino-substituted quinazoline derivatives
发明人：SCHROEDER JUERGEN; DZIEWAS GEORG; FACHINGER THOMAS; JAEGER BURKHARD; REICHEL CARTSEN; RENNER SVENJA
权利人:SCHROEDER JUERGEN; DZIEWAS GEORG; FACHINGER THOMAS; JAEGER BURKHARD; REICHEL CARTSEN; RENNER SVENJA; BOEHRINGER INGELHEIM INT
摘要:The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) n nwherein the groups R a , R b , R c and R d have the meanings given in the claims, as well as sulphonyl derivatives of formulan n nand the use thereof as synthesis components for preparing quinazolines of formula (I). The quinazoline derivatives of formula (I) are inhibitors of signal transduction mediated by tyrosinekinases and by the Epidermal Growth Factor-Receptor (EGF-R) and are therefore particularly suitable for the treatment of tumoral diseases.

专利号:CN-113354591-B
优先权日:2021-06-09
标题 :Synthesis and Antitumor Activity of Alkylaminoquinazolines

专利号:CN-113354591-A
优先权日:2021-06-09
标 题:Synthesis and Antitumor Activity of Alkylaminoquinazolines

专利号:CN-106432105-A
优先权日:2016-08-26
标题 :A kind of chemical synthesis method of meiwatinib