CAS: 292150-20-0; Fmoc-D-Isogln-Oh

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CAS号6893-26-1 D-谷氨酸 | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号19522-40-8 (R)-4,5-二氨基-5-氧代戊酸 | CAS号19522-39-5 Pentanoic acid,... | CAS号63648-73-7 N-CBZ-D-谷氨酸 | CAS号18800-73-2 B°C-L-Glu(OBn)-NH2 | CAS号2578-33-8 D-谷氨酸-5-苄酯 | CAS号35793-73-8 N-B°C-D-谷氨酸 5-苄酯

D-谷氨酸置于palladium On Activated Charcoal Sodium Hydroxide,氢气,碳酸氢钠,N,N'-二环己基碳二亚胺体系中,用 四氢呋喃,水,丙酮 用作溶剂,20.0~60.0 °C,400.0 Kpa 条件下,反应 87.75H,反应生成Fmoc-Alpha-谷氨酸盐
参考文献:A Novel Immunostimulator,N2-[α-O-Benzyl-N-(Acetylmuramyl)-L-Alanyl-D-Isoglutaminyl]-N6-Trans-(M-Nitrocinnamoyl)-L-Lysine,And Its Adjuvancy On The Hepatitis B Surface Antigen
标题:A Novel Immunostimulator,N2-[α-O-Benzyl-N-(Acetylmuramyl)-L-Alanyl-D-Isoglutaminyl]-N6-Trans-(M-Nitrocinnamoyl)-L-Lysine,And Its Adjuvancy On The Hepatitis B Surface Antigen
摘要:N-2-[(Alpha-O-Benzyl-N-(Acetylmuramyl)-L-Alanyl-D-Isoglutaminyl)]-At6-Trans-(M-Nitrocinnamoyl)-L-Lysine (Muramyl Dipeptide C,Or Mdp-C) Has Been Synthesized As A Novel,Nonspecific Immunomodulator. The Present Study Shows That Mdp-C Induces Strong Cytolytic Activity By Macrophages On P388 Leukemia Cells And Cytotoxic Activity By Cytotoxic T Lymphocytes (Ctls) On P815 Mastocytoma Cells. Our Results Also Indicate That Mdp-C Is An Effective Stimulator For Production Of Interleukin-2 And Interleukin-12 By Murine Bone Morrow Derived Dendritic Cells (Bmdcs) And Production Of Interferon-Gamma By Ctls. Additionally,Mdp-C Increases The Expression Levels Of Several Surface Molecules,Including Cd11C,Mhc Class I,And Intercellular Adhesion Molecule-1 In Bmdcs. Moreover,Mdp-C Remarkably Enhances The Immune System'S Responsiveness To Hepatitis B Surface Antigen (Hbsag) In Hepatitis B Virus Transgenic Mice For Both Antibody Production And Specific Hbsag T-Cell Responses Ex Vivo. Our Results Indicate That Mdp-C Is An Apyrogenic,Nonallergenic,And Low-Toxicity Immunostimulator With Great Potential For Diagnostic,Immunotherapeutic,And Prophylactic Applications In Diseases Such As Hepatitis B And Cancers.
Doi:10.1021/jm0493313

专利信息

专利号:US-9085605-B2
优先权日:2010-05-27
标 题:Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate
发明人：LIU GANG; ZHAO NAN; MA YAO
权利人:LIU GANG; ZHAO NAN; MA YAO; SHENZHEN SALUBRIS PHARM CO LTD
摘要:The present invention discloses chemical synthesis, anti-tumor and anti-metastatic effects of a dual functional conjugate as shown by formula I. Specifically, paclitaxel or docetaxol is linked with muramyl dipeptide derivative to form a conjugate, thus dual anti-tumor and anti-metastatic effects are achieved by combination of chemotherapy and immunotherapy. The present invention also discloses that paclitaxel or docetaxol and muramyl dipeptide derivative conjugate is synthesized by combination of solid-phase and solution-phase synthesis, and said conjugate can be used in manufacture of anti-tumor medicaments as proved by reliable bioassays.

专利号:EP-3239139-B1
优先权日:2010-05-27
标题 :Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate

专利号:US-2013143826-A1
优先权日:2010-05-27
标 题 :Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate

专利号:JP-2013529218-A
优先权日:2010-05-27
标 题:Chemical synthesis and anti-tumor and anti-tumor metastatic effects of dual functional conjugates

专利号:WO-2011147330-A1
优先权日:2010-05-27
标题 :Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate

专利号:EP-2612857-B1
优先权日:2010-05-27
标 题:Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate