CAS: 2465-27-2; 4,4'-(Iminomethylene)Bis(N,N-Dimethylaniline) Hydrochloride

双[4-(二甲氨基)苯基]甲烷置于氨,Sulfur,氯化铵体系中,用 二乙二醇 用作溶剂,化学反应 21.0H,以15 G的收率获得碱性槐黄
参考文献:碱性嫩黄o标准检测样品的制备方法
标题:碱性嫩黄o标准检测样品的制备方法
摘要:碱性嫩黄o标准检测样品的制备方法,涉及一种标准检测样品的制备方法,所述方法包括:碱性嫩黄o的合成与纯化:在三口反应瓶内加入乙二醇作溶剂,加入4,4一二甲氨基二苯甲烷,硫磺,通氨气进行搅拌反应,反应后,加入氯化氨,继续通氨气反应后,冷却,结晶,过滤,然后加盐水进行重结晶,过滤,干燥得成品,经过硅胶柱净化,淋洗液为二氯甲烷和甲醇,洗脱液经过避光,低温干燥后得到粗品;该方法制得纯度高,含量准确,均匀性和稳定性均符合要求的标准样品,解决我国检测用标准品依赖进口,为我国食品安全检验检测提供全面实物标准保障,为我国各级政府食品安全监控提供了技术支撑.

专利信息

专利号:WO-2021125500-A1
优先权日:2019-12-17
标题 :Os12bglu38 gene for induction of male sterility in rice and use thereof
发明人：JEON JONG-SEONG; MAHONG BANCHA; LEE SANG-KYU; SHIM SU-HYEON
权利人:UNIV INDUSTRY COOPERATION GROUP KYUNG HEE UNIV
摘要:The present invention relates to Oryza sativa beta-glucosidase 38 (Os12BGlu38) gene, which is predominantly expressed in the late phase of pollen development to regulate the synthesis of intine in pollen cell walls, and a use thereof. The present invention relates to Os12BGlu38 gene, which regulates the synthesis of intine in pollen cell walls to ultimately induce male sterility in rice, a protein thereof, a dysfunctional mutant, a transgenic plant and a seed thereof, a method for regulating synthesis of intine in pollen cell walls of plants by expressing the gene in the plants, a method for inducing male sterility, and a pharmaceutical composition for induction of male sterility in plants.

专利号:US-9625466-B2
优先权日:2011-04-06
标题 :Signal amplification methods for the imaging of protein synthesis and neurotransmitter transport
发明人：BLANCHARD SCOTT C; ALTMAN ROGER B
权利人:BLANCHARD SCOTT C; ALTMAN ROGER B; UNIV CORNELL
摘要:The present invention describes the synthesis of biological samples that can be used for the purpose of enhancing the signal-to-noise ratios achievable during the imaging of protein synthesis, amino acid transport and neurotransmitter transport, particularly in applications where single-molecule resolution is demanded. The present invention provides quencher-labeled elongation factor (EF-Tu) and fluorophore-labeled tRNA. When these molecules are present in a ternary complex with GTP, the fluorescently-labeled tRNA is quantitatively quenched. Once the tRNA is incorporated into an actively translating ribosome, however, a burst of fluorescence is released and can be detected by a variety of techniques, including smFRET imaging. The invention further provides novel EF-Tu constructs for achieving quencher labeling at high levels while retaining native or near native activity in the translation reactions, as well as methods for preparing stable ternary complexes, methods of protein sequencing, methods of detecting amino acid transport using a proteoliposome assay system and the proteoliposomes systems and methods of imaging translation events in single living cells. The present invention should have an immediate impact on next-generation sequencing technologies and the detection of neurotransmitter transporter activities in both in vitro and in vivo settings, a critical component of drug activity/screening assays targeting this important class of molecules.

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-2018150597-A1
优先权日:2016-11-29
标题 :Method for optimal design of polynucleotides sequences for analysis of specific events in any genetic region of interest
发明人：BERTHOUMIEUX SARA; FOURNE YANNICK; KOMATSU JUN; FER FREDERIC; BENSIMON AARON
权利人:GENOMIC VISION SA
摘要:Methods including in-silico steps for design and synthesis of Genomic Morse Code (“GMCâ€?) probes including design of combinations of polynucleotide sequences and labelling colors for analysis of large rearrangements in targeted genetic regions as well as allele characterization of complex regions and localization of events such as replication, DNA reparation or epigenetics in particular regions. Color-encoded sets of probes that produce characteristic or unique color patterns when painted on a target nucleic acid sequence. Methods for using color-encoded sets of probes.

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-2024350645-A1
优先权日:2021-07-22
标 题 :Automated synthesis of polymeric drugs
发明人：MATRAY TRACY; VANBRUNT MICHAEL; MCCUTCHEON JOHN MICHAEL
权利人:SONY GROUP CORP
摘要:Compounds useful as biologically active compounds are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein L 1 , L 2 , L 3 , R 1 R 2 , M, p, q, m, and n are as defined herein. Additional compounds, methods of preparation, pharmaceutical compositions, and methods of treatment related to compounds of Structure (I) are also provided.