CAS: 240401-22-3; Piperidine-4-Carbonitrile Hydrochloride

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4395-98-6 91419-52-2 62718-31-4

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CAS号91419-52-2 N-B°C-4-氰基哌啶 | CAS号872-50-4 N-甲基吡咯烷酮(NMP) | CAS号178308-63-9 1-Chloro-4-(3-c...

哌啶-4-甲酰胺置于盐酸,三氯氧磷体系中,用 1,4-二氧六环 用作溶剂,化学反应 20.75H,反应生成4-氰基哌啶盐酸盐
参考文献:Benzoxazinyl-Amidocyclopentyl-Heterocyclic Modulators Of Chemokine Receptors
标题:Benzoxazinyl-Amidocyclopentyl-Heterocyclic Modulators Of Chemokine Receptors
摘要:环戊基化合物通过酰胺基团与苯并噁唑基团相连,利用苯并噁唑环的环氮原子,并进一步用杂环基团取代,这些化合物由式i表示: 用于调节ccr-2趋化因子受体,以预防或治疗炎症和免疫调节性疾病和疾病,过敏性疾病,包括过敏性鼻炎,皮炎,结膜炎和哮喘,以及类风湿性关节炎和动脉粥样硬化等自身免疫病理病变;以及包含这些化合物的药物组合物和这些化合物和组合物的使用.

专利信息

专利号:US-6319932-B1
优先权日:1998-11-10
标 题 :Oxazolidinones useful as alpha 1A adrenoceptor antagonists
发明人：NERENBERG JENNIE B; BOCK MARK G; SELNICK HAROLD G; PAYNE LINDA
权利人:MERCK & CO INC
摘要:Novel oxazolidinone compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.

专利号:WO-2023057548-A1
优先权日:2021-10-07
标题:Ccr6 receptor modulators
发明人：AISSAOUI HAMED; ALLEMANN OLIVER; CAROFF EVA; MEYER EMMANUEL; RICHARD-BILDSTEIN SYLVIA
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the prevention or treatment of e.g. inflammatory/autoimmune diseases/disorders and cancer.

专利号:CN-114773256-B
优先权日:2022-03-23
标 题 :Synthesis method of 4-cyano piperidine