专利号:US-5338686-A 优先权日:1992-04-29 标 题:Method for measuring in vivo synthesis of biopolymers 发明人:HELLERSTEIN MARC K 权利人:HELLERSTEIN MARC K 摘要:A method for determining the mass isotope enrichment of a subunit from which a biopolymer is formed, and the rates of synthesis and decay of the biopolymer. The mass isotope enrichment of the subunit is determined by comparing the mass isotopomer distribution of the biopolymer after administration of a mass isotopically labeled subunit, with the expected frequencies of the different mass isotopomers produced from a given subunit mass isotope enrichment. To determine the synthesis rate of the biopolymer, the expected frequency of a selected biopolymer mass isotopomer, calculated from the subunit isotope enrichment, is compared with the actual frequency of that biopolymer mass isotopomer. To determine biopolymer decay, the decay rate of high mass isotopomers of the biopolymer is determined.
专利号:CN-110441447-B 优先权日:2019-09-11 标题:Deuterated sulfamethoxazole-d4Method of synthesis of
参考文献:10.1021/ac0496603 摘要:Göbel A, McArdell CS, Suter MJ, Giger W. Trace determination of macrolide and sulfonamide antimicrobials, a human sulfonamide metabolite, and trimethoprim in wastewater using liquid chromatography coupled to electrospray tandem mass spectrometry. Anal Chem. 2004 Aug 15;76(16):4756–64. doi: 10.1021/ac0496603.