CAS: 19347-73-0; 6-Chlorohexanoyl Chloride

相似化合物

22809-37-6 1575-61-7 52387-36-7

上下游产品

hexahydro-2H-oxepin-2-one Hexanoyl chloride chlorine benzene 6-Chloro-hexanoic acid (2-cyanomethyl-4,5-dimethoxy-phenyl)-amide 6-Chloro-hexanoic acid (2-cyano-phenyl)-amide ε-chlorohexanophenone

6-己内酯置于氯化亚砜,Zinc(II) Chloride体系中,用51%的收率获得6-氯己酰氯
参考文献:合成和评估一些稳定的多底物加合物作为亚精胺合酶的特异性抑制剂.
标题:合成和评估一些稳定的多底物加合物作为亚精胺合酶的特异性抑制剂.
摘要:设计了一系列新的氨基丙基转移酶抑制剂,其中亲核氨基丙基受体与氨基丙基供体s-腺苷-1-(甲硫基)-3-丙胺(脱羧的s-腺苷甲硫氨酸)连接,形成"多底物加合物".在当前情况下,已经合成了s-腺苷-1,8-二氨基-3-硫辛烷(2B)和相应的甲基thy盐(3B).分析了几种这类化合物作为亚精胺合酶的抑制剂,发现2B和3B均为该酶的有效抑制剂.硫醚2B是迄今为止描述的最有效的亚精胺合酶抑制剂,几乎完全没有针对紧密相关的氨丙基转移酶精胺合酶的抑制活性.
Doi:10.1021/jm00143A003

专利信息

专利号:US-11518780-B2
优先权日:2019-07-31
标 题:Sensitive oligonucleotide synthesis using sulfur-based functions as protecting groups and linkers
发明人：FANG SHIYUE
权利人:FANG SHIYUE
摘要:Embodiments for the synthesis of sensitive oligonucleotides as well as insensitive oligonucleotides are provided. Sulfur-based groups are used for the protection of exo-amino groups of nucleobases, phosphate groups and 2′—OH groups, and as cleavable linker for linking oligonucleotides to a support. Oligonucleotide syntheses are achieved under typical conditions using phosphoramidite chemistry with important modifications. To prevent replacing sulfur-based protecting groups by acyl groups via cap-exchange, special capping agents are used. To retain hydrophobic tag to assist RP HPLC purification, special phosphoramidites are used in the last synthetic cycle. With the sulfur-based groups for protection and linking, oligonucleotide deprotection and cleavage are achieved via oxidation followed by beta-elimination under mild conditions. Therefore, besides for insensitive oligonucleotide synthesis, the embodiments of the invention are capable for the synthesis of oligonucleotide analogs containing sensitive functional groups that cannot survive the harsh conditions used in prior art oligonucleotide synthesis technologies.

专利号:US-9751851-B2
优先权日:2013-09-20
标 题:Molecules and compositions that inhibit gram negative bacteria and their uses
发明人：BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; CONRAD-MILLER LAURA C; O'LOUGHLIN COLLEEN T
权利人:UNIV PRINCETON; BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; MILLER LAURA C; O'LOUGHLIN COLLEEN T
摘要:Antivirulence strategies to combat Pseudomonas aeruginosa , are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.

专利号:US-5130478-A
优先权日:1989-12-06
标题:Process for the preparation of chlorides of chlorinated carboxylic acids
发明人：GAUTHIER PATRICIA P; LE MOULT MICHEL M; ROCHELLE CLAUDE; SENET JEAN-PIERRE G
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The invention relates to a process for the preparation of chlorides of chlorinated carboxylic acids of formula in which R2 denotes the radical (CH2)n, n being an integer from 2 to 4, or the radical -CH2-C(C6H5)2- and R1 denotes a hydrogen atom or an alkyl radical containing from 1 to 4 carbon atoms, which consists in reacting the lactones of formula in which R1 and R2 have the above meanings, with phosgene at a temperature of 90 DEG to 180 DEG C., while employing as catalysts trisubstituted phosphine oxides or sulphides. The process according to the invention makes it possible to obtain chlorides of chlorinated carboxylic acids of high purity which exhibit an excellent stability to light and to heat and which are very useful as synthesis intermediates.

专利号:CN-110790724-B
优先权日:2019-09-20
标题:A kind of selective carbonic anhydrase inhibitor and its synthesis method and application

专利号:CN-110790724-A
优先权日:2019-09-20
标题 :A kind of selective carbonic anhydrase inhibitor and its synthesis method and application