CAS: 1452-94-4; Ethyl 2-Chloropyridine-3-Carboxylate

相似化合物

2942-59-8 36404-88-3 42330-59-6

上下游产品

CAS号2942-59-8 2-氯烟酸 | CAS号75-03-6 碘乙烷 | CAS号64-17-5 乙醇 | CAS号49609-84-9 2-氯-3-吡啶羧酸 | CAS号74-96-4 溴乙烷 | CAS号14906-63-9 3-Pyridinecarbo... | CAS号18964-26-6 ethyl 2-chloro-... | CAS号105-56-6 氰乙酸乙酯 | CAS号109635-43-0 (2-imino-1H-ben... | CAS号109274-84-2 Furo[2,3-b]pyri... | CAS号35620-71-4 2-苯氧基烟酸 | CAS号38677-85-9 氟尼辛葡甲胺 | CAS号49609-84-9 2-氯-3-吡啶羧酸 | CAS号54629-13-9 2-(4-氟苯氧基)烟酸 | CAS号141872-21-1 3-Pyridinecarbo... | CAS号192817-83-7 ethyl 2-piperid... | CAS号23985-95-7 6H-benzo[h][1,6... | CAS号27038-48-8 呋喃并[2,3-b]吡啶-3(2H)-酮 | CAS号208517-35-5 2-(三氟甲基)烟酸乙酯

2-氯烟酸置于氯化亚砜体系中,用 苯 用作溶剂,化学反应 3.33H,反应生成2-氯烟酸乙酯
参考文献:2-(烷基氨基)烟酸及其类似物.强大的血管紧张素ii拮抗剂.
标题:2-(烷基氨基)烟酸及其类似物.强大的血管紧张素ii拮抗剂.
摘要:人们发现,通过-Ch2-Nr'-连接(1)连接到联苯四唑的一系列吡啶和其他六元环杂环是有效的血管紧张素ii拮抗剂.在嘧啶羧酸系列中(w = Cr,X = N,Y = Ch,Z = Cooh),环外氮上带有烷基(r')的化合物比带有烷基(R)的化合物更有效在杂环上.相应的吡啶,哒嗪,吡嗪和1,2,4-三嗪羧酸也显示出有效的体外血管紧张素ii拮抗作用.吡啶(w,X,Y = Ch,Z = Cooh,R'= N-C3H7)具有很强的体外活性(pa2 = 10.10,兔主动脉,Ki = 0.61 Nm,大鼠肝脏中的受体结合)以及出色的口服降压活性和生物利用度.
Doi:10.1021/jm00070A012

专利信息

专利号:US-8686157-B2
优先权日:2003-02-10
标题:Processes for the facile synthesis of diaryl amines and analogues thereof
发明人：SNOONIAN JOHN R; OLIVER-SHAFFER PATRICIA ANN
权利人:SNOONIAN JOHN R; OLIVER-SHAFFER PATRICIA ANN; VERTEX PHARMA
摘要:The present invention relates to processes for the facile synthesis of diaryl amines and analogues thereof. The processes of the present invention produce diaryl amines in high yield and purity. The present invention also relates to intermediates useful in the process of the present invention.

专利号:EP-1404682-B1
优先权日:2001-06-29
标题:Method of inhibiting ptp 1b and/or t-cell ptp and/or other ptpases with an asp residue at position 48
发明人：HANSEN THOMAS KRUSE; OLSEN OLE HVILSTED; PETERSEN ANDERS KLARSKOV; LAU JESPER; ANDERSEN HENRIK SUNE; MOLLER NIELS PETER HUNDAHL
权利人:NOVO NORDISK AS
摘要:This invention relates to oxalylamide inhibitors of Protein Tyrosine Phosphatase 1B (PTP1B) and/or T-cell Protein Tyrosine Phosphatase (TC-PTP) and/or Protein Tyrosine Phosphatases (PTPases) having an aspartic acid (Asp) in position 48 (PTP1B numbering, Chernoff et al., Proc. Natl. Acad. Sci. USA 87: 2735-2789 (1989)) and a method of inhibiting such PTPases by exposing the enzyme to inhibitor compounds of formula 1. This invention also relates to (I) the design and selection of inhibitors, which bind to the active site of PTP1B and/or TC-PTP and/or PTPases having an aspartic acid (Asp) in position 48 (II) the synthesis of said inhibitors, methods for their preparation and (III) to compositions comprising the inhibitor compounds.

专利号:US-2003064979-A1
优先权日:2001-06-29
标题 :Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48
发明人：HANSEN THOMAS KRUSE; OLSEN OLE HVILSTED; PETERSEN ANDERS KLARSKOV; LAU JESPER; ANDERSEN HENRIK SUNE; MOLLER NIELS PETER HUNDAHL
摘要:This invention relates to oxalylamide inhibitors of Protein Tyrosine Phosphatase 1B (PTP1B) and/or T-cell Protein Tyrosine Phosphatase (TC-PTP) and/or Protein Tyrosine Phosphatases (PTPases) having an aspartic acid (Asp) in position 48 (PTP1B numbering, Chernoff et al, Proc Natl Acad Sci USA 87: 2735-2789 (1989)) and a method of inhibiting such PTPases by exposing the enzyme to inhibitor compounds of formula 1 n n n This invention also relates to (I) the design and selection of inhibitors, which bind to the active site of PTP1B and/or TC-PTP and/or PTPases having an aspartic acid (Asp) in position 48 (II) the synthesis of said inhibitors, methods for their preparation and (III) to compositions comprising the inhibitor compounds.

专利号:US-2025236897-A1
优先权日:2022-02-16
标 题 :Processes for preparation of avacopan and intermediates thereof
发明人：GYUJTO IMRE; PAAL TIHAMER; JUHASZ ZSUZSA POTARINE; ESZENYI DANIEL; ZAHUCZKY GABOR JOZSEF; KONDOR ZOLTAN; RENGASAMY VADIVELAN; PRAJAPATI RAMKARAN; DAUND VAIBHAV SURESH; SAINGER SHACHI; KADU RUSHIKESH; SHARMA VISHAL
权利人:TEVA PHARMACEUTICALS INT GMBH
摘要:The present disclosure encompasses a process for chiral resolution of racemic amines, particularly ethyl 2-(4-((tert-butoxycarbonyl)amino)phenyl)piperidine-3-carboxylate, into its desired isomer, ethyl (2R,3S)-2-(4-((tert-butoxycarbonyl)amino)phenyl)-piperidine-3-carboxylate, which is an intermediate useful in the synthesis of Avacopan.

专利号:US-5248781-A
优先权日:1992-09-21
标题 :Preparation of substituted anilino-nicotinic acid derivatives
发明人：MCKILLOP ALEXANDER
权利人:UNIV PRINCETON
摘要:Substituted anilino-nicotinic acid derivatives are readily prepared from the condensation of two intermediates, 2-alkyl-3-perfluoroalkyl-anilines and alkyl 2-chloronicotinates. The 2-alkyl-3-perfluoroalkyl-aniline intermediate can be prepared via a novel three step synthesis. 3-Perfluoroalkyl-anilines are reacted with an amine directing protecting group reagent to protect the amine. The protected amine is then alkylated, and finally, the directing group is removed to form the 2-alkyl-3-perfluoroalkyl-aniline intermediate. The 2-alkyl-3-perfluoroalkyl-aniline intermediate is condensed with the alkyl 2-chloronicotinate to form the anilino-nicotinic acid derivative.

专利号:US-2007173649-A1
优先权日:2003-02-10
标 题:Processes for the facile synthesis of diaryl amines and analogues thereof