CAS: 143-62-4; Digitoxigenin

该化合物是一种来自狐球植物(Digitalis purpurea)的卡德奥利德类固醇,它作为心脏胶质生物合成(如digoxin和digoxin)的一种关键丙酮前体,对治疗心脏衰竭和不相近性的积极非遗传效应具有临床意义. 狄氏素与纳+/K+-ATPase泵具有高度的结合性,因此对研究离子传输机制和心脏药理很有价值. 其明确界定的结构和生物活动也使其在生物化学研究中有用, 特别是在探索类固醇-受体相互作用和细胞毒性实验方面. 高纯度时, 狄氏素是分析和药理学应用的可靠参考标准.

结构式图片

相似化合物

4562-36-1 4701-54-6 13011-12-6

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CAS号71-63-6 洋地黄毒苷 | CAS号809-98-3 14-hydroxy-3β-t... | CAS号101053-28-5 (1S,6R)-8,8-eth... | CAS号1102-88-1 (5beta)-14-hydr... | CAS号508-93-0 (3beta,5beta)-3... | CAS号2873-29-2 三乙酰葡萄糖烯 | CAS号135414-66-3 Gitoxigenin | CAS号508-88-3 (17α)-3α,14-Dih... | CAS号545-26-6 芰皂配基 | CAS号33156-28-4 兰诺地近

合成工艺路线路线简述

    📜洋地黄毒苷置于水体系中,化学反应生成毛地黄毒苷配基
    参考文献:Ketoimines Of Cardenolides
    标题:Ketoimines Of Cardenolides
    摘要:制备了数字苷甙和心源甙的3-酮衍生物,并随后转化为新的酮亚胺(1-19,24-44),肟(23),以及首次获得纯心源甙(14,16-二脱水数字苷甙,20),其醋酸酯(21)和心源酮(22).描述了它们的物理化学性质.
    Doi:10.1007/s10600-005-0073-3

    海关参考信息

    专利信息


    专利号:US-2012190064-A1
    优先权日:2004-10-01
    标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
    发明人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
    权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
    摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

    专利号:US-2002055185-A1
    优先权日:1997-08-07
    标 题 :Complex chemical compound, synthesis and various applications of said compound
    发明人:MINARD CLAIRE; CHAIX CAROLE; DELAIR THIERRY; MANDRAND BERNARD
    摘要:The invention concerns a complex chemical compound comprising a solid carrier and at least a conjugate consisting of an organic polymer and a plurality of priming biomers. The invention also concerns the synthesis of said chemical compound for biopolymer synthesis and the use of said complex chemical compound after synthesis as ligand for amplifying or detecting and/or capturing target molecules.

    专利号:US-3595883-A
    优先权日:1969-06-16
    标 题 :Process for the preparation of 14beta-hydroxy - 17 -keto - 15 - androstenes and novel intermediates produced thereby
    发明人:AFONSO ADRIANO
    权利人:SCHERING CORP
    摘要:14B-HYDROPEROXY-15-ANDROSTEN-17-ONES, PREPARED BY THE ACTION OF OXYGEN ON 14-ANDROSTEN-17-ONES, UPON TREATMENT WITH A MILD REDUCING AGENT YEILDS 14B-HYDROXY-15ANDROSTEN-17-ONES, USEFUL INTERMEDIATES IN THE SYNTHESIS OF STERODIAL CARDENOLIDES. PREFERRED SPECIES ARE 14 B-HYDROPEROXY-5A-15 ANDROSTEN3B-OL-17-ONE 3-ACETATE AND THE 5B-EPIMER THEREOF (PREPARED BY THE ACTION OF OXYGEN OR 5A-14-ANDROSTEN-3B-OL17-ONE 3-ACETATE AND THE 5B-EPIMER THEREOF, RESPECTIVELY) EACH OF WHICH, UPON MILD REDUCTION, PREFERABLY WITH TRIETHYL PHOSPHITE, YEILDS 14B-HYDROXY-5A-15-ANDROSTEN-3BOL-17-ONE 3-ACETATE AND THE 5B-EPIMER THEROF, RESPECTIVELY, WHICH ARE USEFUL INTERMEDIATES IN THE SYNTHESIS OF UZARIGENIN AND DIGITOXIGENIN, RESPECTIVELY.

    专利号:WO-9636627-A1
    优先权日:1995-05-19
    标 题 :Collection of activated glycoside compounds and their biological use
    发明人:ANDERSON MARK BRIAN; MUSSER JOHN H
    权利人:GLYCOMED INC
    摘要:The present invention relates to the field of combinatorial carbohydrate chemistry and involves the modification of organic molecules and/or the synthesis of large numbers of products comprising carbohydrate and/or glycominetic entities. More specifically, the present invention relates to activated carbon glycosides useful for the modification of organic molecules by incorporation of carbohydrate units, providing the synthesis of large numbers of products having novel chemical characteristics. The present invention further relates to methods for the generation of chemical compounds comprising carbon glycosides. Methods are disclosed to provide large arrays of molecules and to identify species that act as agonists or antagonists of various biological, chemical, and other activities.

    专利号:US-4259240-A
    优先权日:1979-09-28
    标 题:Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom
    发明人:WIESNER KAREL; TSAI THOMAS Y R
    权利人:ADVANCE BIOFACTURES CORP
    摘要:The invention relates to furyl intermediates and the preparation thereof, said intermediates being particularly useful in the preparation of synthetic cardenolides and their isomers. The process provides for the reaction of an unsaturated steroidal 17 ketone with a β-furyl compound to produce an allylic alcohol which is subjected to acetylation and allylic rearrangement. The resulting material is then hydrogenated to produce the furyl intermediate. Cardenolides are formed therefrom by oxidation of the furyl intermediates.

    专利号:US-3828029-A
    优先权日:1972-06-13
    标题:Synthesis of 14beta hydroxysteroids
    发明人:ABERHART D; CASPI E
    权利人:CASPI E; ABERHART D
    摘要:THERE IS PROVIDED A NOVEL METHOD OF INSERTING A 14BHYDROXY GROUP INTO STEROID NUCLEI UNSUBSTITUTED AT THAT POSITION AND IN PARTICULAR THERE IS PROVIDED A METHOD OF CONVERTING 3,22-DIHYDROXY-23,24-DINOR-5$-CHOLENES OR THE 3-ACYLATES THEREOF INTO THE CORRESPONDING 3, 14B,22-TRIHYDROXY-23,24-DINOR-5$-CHOLANES AND THE 3,22-DIACYLATES THEREOF. THIS METHOD ALSO PROVIDES A NOVEL AND SIMPLE MEANS OF SYNTHESIZING DIGITOXIGENIN.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Prisbe EJ, Verheyden JP, Montgomery WW, Strosberg AM. Digitoxigenin 3-O-beta- D-furanosides. J Med Chem. 1986 Feb;29(2):239-44. doi: 10.1021/jm00152a012. 53(6):1382-5. German. doi: 10.1002/hlca.19700530618. 5(1):21. doi: 10.3390/bioengineering5010021.
    4: Danieli N, Mazur Y, Sondheimer F. The synthesis of digitoxigenin. Tetrahedron. 1966 Sep;22(9):3189-93. doi: 10.1016/s0040-4020(01)82299-7. 24(17):1639-41. 120(1):321-335. doi: 10.1007/s00436-020-06971-2. Epub 2020 Nov 16.
    7: Munkert J, Gomes ER, Marostica LL, Cota BB, Lopes CLM, Andrade SF, Filho JDS, Alves RJ, Oliveira MC, Braga FC, Simões CMO, Pádua RM, de Barros ALB. New 99mTc-Labeled Digitoxigenin Derivative for Cancer Cell Identification. ACS Omega. 2019 Dec 11;4(26):22048-22056. doi: 10.1021/acsomega.9b03167.

    合成参考文献


    摘要:Chemical and Pharmaceutical Bulletin., 8(18), 1960
    摘要:Arzneimittel-Forschung. Drug Research., 11(848), 1961 []
    参考文献:10.1248/cpb.44.615
    摘要:Kitanaka S, Takido M, Mizoue K, Nakaike S. Cytotoxic cardenolides from woods of Euonymus alata. Chem Pharm Bull (Tokyo). 1996 Mar;44(3):615–7. doi: 10.1248/cpb.44.615.
    参考文献:10.1023/a:1007747623749
    摘要:Maixent JM, Lelièvre L, Berrebi-Bertrand I. Mechanism underlying the strong positive inotropic effects of LND-623: specific inhibition of Na, K-ATPase isoforms and exclusion of cellular sites of contractile control. Cardiovasc Drugs Ther. 1998 Dec;12(6):585–94. doi: 10.1023/a:1007747623749.
    参考文献:10.1007/s10637-006-7772-x
    摘要:Mekhail T, Kaur H, Ganapathi R, Budd GT, Elson P, Bukowski RM. Phase 1 trial of Anvirzel in patients with refractory solid tumors. Invest New Drugs. 2006 Sep;24(5):423–7. doi: 10.1007/s10637-006-7772-x.
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