📜洋地黄毒苷置于水体系中,化学反应生成毛地黄毒苷配基 参考文献:Ketoimines Of Cardenolides 标题:Ketoimines Of Cardenolides 摘要:制备了数字苷甙和心源甙的3-酮衍生物,并随后转化为新的酮亚胺(1-19,24-44),肟(23),以及首次获得纯心源甙(14,16-二脱水数字苷甙,20),其醋酸酯(21)和心源酮(22).描述了它们的物理化学性质. Doi:10.1007/s10600-005-0073-3
专利号:US-2012190064-A1 优先权日:2004-10-01 标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules 发明人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA 权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP 摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.
专利号:US-2002055185-A1 优先权日:1997-08-07 标 题 :Complex chemical compound, synthesis and various applications of said compound 发明人:MINARD CLAIRE; CHAIX CAROLE; DELAIR THIERRY; MANDRAND BERNARD 摘要:The invention concerns a complex chemical compound comprising a solid carrier and at least a conjugate consisting of an organic polymer and a plurality of priming biomers. The invention also concerns the synthesis of said chemical compound for biopolymer synthesis and the use of said complex chemical compound after synthesis as ligand for amplifying or detecting and/or capturing target molecules.
专利号:US-3595883-A 优先权日:1969-06-16 标 题 :Process for the preparation of 14beta-hydroxy - 17 -keto - 15 - androstenes and novel intermediates produced thereby 发明人:AFONSO ADRIANO 权利人:SCHERING CORP 摘要:14B-HYDROPEROXY-15-ANDROSTEN-17-ONES, PREPARED BY THE ACTION OF OXYGEN ON 14-ANDROSTEN-17-ONES, UPON TREATMENT WITH A MILD REDUCING AGENT YEILDS 14B-HYDROXY-15ANDROSTEN-17-ONES, USEFUL INTERMEDIATES IN THE SYNTHESIS OF STERODIAL CARDENOLIDES. PREFERRED SPECIES ARE 14 B-HYDROPEROXY-5A-15 ANDROSTEN3B-OL-17-ONE 3-ACETATE AND THE 5B-EPIMER THEREOF (PREPARED BY THE ACTION OF OXYGEN OR 5A-14-ANDROSTEN-3B-OL17-ONE 3-ACETATE AND THE 5B-EPIMER THEREOF, RESPECTIVELY) EACH OF WHICH, UPON MILD REDUCTION, PREFERABLY WITH TRIETHYL PHOSPHITE, YEILDS 14B-HYDROXY-5A-15-ANDROSTEN-3BOL-17-ONE 3-ACETATE AND THE 5B-EPIMER THEROF, RESPECTIVELY, WHICH ARE USEFUL INTERMEDIATES IN THE SYNTHESIS OF UZARIGENIN AND DIGITOXIGENIN, RESPECTIVELY.
专利号:WO-9636627-A1 优先权日:1995-05-19 标 题 :Collection of activated glycoside compounds and their biological use 发明人:ANDERSON MARK BRIAN; MUSSER JOHN H 权利人:GLYCOMED INC 摘要:The present invention relates to the field of combinatorial carbohydrate chemistry and involves the modification of organic molecules and/or the synthesis of large numbers of products comprising carbohydrate and/or glycominetic entities. More specifically, the present invention relates to activated carbon glycosides useful for the modification of organic molecules by incorporation of carbohydrate units, providing the synthesis of large numbers of products having novel chemical characteristics. The present invention further relates to methods for the generation of chemical compounds comprising carbon glycosides. Methods are disclosed to provide large arrays of molecules and to identify species that act as agonists or antagonists of various biological, chemical, and other activities.
专利号:US-4259240-A 优先权日:1979-09-28 标 题:Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom 发明人:WIESNER KAREL; TSAI THOMAS Y R 权利人:ADVANCE BIOFACTURES CORP 摘要:The invention relates to furyl intermediates and the preparation thereof, said intermediates being particularly useful in the preparation of synthetic cardenolides and their isomers. The process provides for the reaction of an unsaturated steroidal 17 ketone with a β-furyl compound to produce an allylic alcohol which is subjected to acetylation and allylic rearrangement. The resulting material is then hydrogenated to produce the furyl intermediate. Cardenolides are formed therefrom by oxidation of the furyl intermediates.
专利号:US-3828029-A 优先权日:1972-06-13 标题:Synthesis of 14beta hydroxysteroids 发明人:ABERHART D; CASPI E 权利人:CASPI E; ABERHART D 摘要:THERE IS PROVIDED A NOVEL METHOD OF INSERTING A 14BHYDROXY GROUP INTO STEROID NUCLEI UNSUBSTITUTED AT THAT POSITION AND IN PARTICULAR THERE IS PROVIDED A METHOD OF CONVERTING 3,22-DIHYDROXY-23,24-DINOR-5$-CHOLENES OR THE 3-ACYLATES THEREOF INTO THE CORRESPONDING 3, 14B,22-TRIHYDROXY-23,24-DINOR-5$-CHOLANES AND THE 3,22-DIACYLATES THEREOF. THIS METHOD ALSO PROVIDES A NOVEL AND SIMPLE MEANS OF SYNTHESIZING DIGITOXIGENIN.