CAS: 1270138-40-3; (4-Benzylpiperazin-1-yl)(2-(Isopentylamino)Pyridin-3-yl)Methanone
- 英文名称(4-Benzylpiperazin-1-yl)(2-(Isopentylamino)Pyridin-3-yl)Methanone
- 中文名称[2-[(3-甲基丁基)氨基]-3-吡啶基][4-(苯基甲基)-1-哌嗪基]甲酮
- IUPAC名称(4-benzylpiperazin-1-yl)(2-(isopentylamino)pyridin-3-yl)methanone
- 其它别名Diethylcarbamazine Citrate [usp:Jan]; (4-Benzylpiperazin-1-yl)-[2-(Isopentylamino)-3-Pyridyl]Methanone; Methanone, (2-((3-Methylbutyl)Amino)-3-Pyridinyl)(4-(Phenylmethyl)-1-Piperazinyl)-; Yve9U40
- CAS编号1270138-40-3
- MFCD编号:MFCD26959792
- EINECS号:826-706-6
- FDA UNII编号:YVE9U408ZL
- 分子式:C22H30N4O分子量:366.51
- 产品CID: 429352
- 同类组份化合物CAS1270138-40-3 (free base)1270138-41-4 (phosphate)
- 产品分类生物化工 → 生化试剂 → 激动剂抑制剂
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
2-Chloronicotinoyl chloride 1-(2-chloronicotinoyl)-4-tert-butoxycarbonylpiperazine 17H18ClN3°C17H18ClN3O 1-amino-3-methylbutane合成工艺路线路线简述
📜(4-Benzylpiperazin-1-yl)(2-Chloropyridin-3-yl)Methanone 以80的收率获得[2-[(3-甲基丁基)氨基]-3-吡啶基][4-(苯基甲基)-1-哌嗪基]甲酮
参考文献:Synthesis Of A Neurostimulative Piperazine
标题:Synthesis Of A Neurostimulative Piperazine
摘要:该发明描述了一种改进的合成方法,用于合成与烟酸和苄基衍生的哌嗪.产品化合物可用于治疗神经系统疾病.
海关参考信息
- 2902300000-甲苯
2912110000-甲醛
2921211000-乙二胺
2924191000-二甲基甲酰胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9481649-B2
优先权日:2009-08-24
标题 :Synthesis of a neurostimulative piperazine
发明人：VENKATRAMAN SRIPATHY; MAHMOOD SYED; MOBELE BINGIDIMI I; LAPINA OLGA; VERCOE KELLIE; LI YING; SALSBURY JONATHAN; MCLAWS MARK
权利人:NEURALSTEM INC
摘要:The invention describes an improved synthesis for piperazine derivatized with nicotinic acid and a benzyl moiety. The product compounds are useful for treatment of neurological conditions.
专利号:WO-2011028548-A1
优先权日:2009-08-24
标 题 :Synthesis of a neurostimulative piperazine
专利号:US-2016090358-A1
优先权日:2009-08-24
标题 :Synthesis of a neurostimulative piperazine
专利号:US-2013005974-A1
优先权日:2009-08-24
标 题 :Synthesis of a neurostimulative piperazine
专利号:US-9278933-B2
优先权日:2009-08-24
标题 :Synthesis of a neurostimulative piperazine
专利号:EP-2470182-B1
优先权日:2009-08-24
标题 :Synthesis of a neurostimulative piperazine
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Zhu S, Shi J, Jin Q, Zhang Y, Zhang R, Chen X, Wang C, Shi T, Li L. Mitochondrial dysfunction following repeated administration of alprazolam causes attenuation of hippocampus-dependent memory consolidation in mice. Aging (Albany NY). 2023 Oct 5;15(19):10428-10452. doi: 10.18632/aging.205087. Epub 2023 Oct 5.
2: Jolivalt CG, Aghanoori MR, Navarro-Diaz MC, Han MM, Sanchez G, Guernsey L, Quach D, Johe K, Fernyhough P, Calcutt NA. Enhancement of Mitochondrial Function by the Neurogenic Molecule NSI-189 Accompanies Reversal of Peripheral Neuropathy and Memory Impairment in a Rat Model of Type 2 Diabetes. J Diabetes Res. 2022 Jul 4;2022:8566970. doi: 10.1155/2022/8566970.
3: Johe KK, Kay G, Kumar S, Burdick KE, McIntyre RS, Papakostas GI, Fava M. NSI-189 phosphate, a novel neurogenic compound, selectively benefits moderately depressed patients: A post-hoc analysis of a phase 2 study of major depressive disorder. Ann Clin Psychiatry. 2020 Aug;32(3):182-196. 68(11):2143-2154. doi: 10.2337/db19-0271. Epub 2019 Sep 6.
合成参考文献
参考文献:10.1002/jcp.25847
摘要:Tajiri N, Quach DM, Kaneko Y, Wu S, Lee D, Lam T, Hayama KL, Hazel TG, Johe K, Wu MC, Borlongan CV. NSI‐189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats. Journal Cellular Physiology. 2017 Apr 25;232(10):2731–40. doi: 10.1002/jcp.25847.
摘要:S61 | UJICCSLIB | Collision Cross Section (CCS) Library from UJI | DOI:10.5281/zenodo.3549476
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