专利号:US-2017320908-A1 优先权日:2014-11-19 标题 :Solid phase synthesis of cyclic amino acid molecules 发明人:HICKEY JENNIFER L; MANCUSO JOHN; MARSAULT ERIC; ROUGHTON ANDREW L; TREDER ADAM P; TREMBLEY MARIE-CLAUDE J; YUDIN ANDREI K; ZARETSKY SERGE 权利人:ENCYCLE THERAPEUTICS; GOVERNING COUNCIL OF THE UNIV OF TORONTO; UNIV SHERBROOKE 摘要:The present invention relates to cyclic amino acid molecules and methods of preparing the same, and in particular the macrocyclization of amino acids or linear peptides bound to a solid support.
专利号:US-2014296354-A1 优先权日:2013-04-01 标题 :Synthesis of peptoid-based small molecular gelators from multiple component reactions 发明人:WANG GUIJUN; MANGUNURU HARI P R 权利人:WANG GUIJUN; MANGUNURU HARI P R; OLD DOMINION UNIV RES FOUND 摘要:Described herein are the one-pot synthesis and characterization of a library of low molecular weight peptoid compounds that are able to form gels at room temperature. The compounds are synthesized from biologically-based starting materials, are biocompatible, and are resistant to degradation by proteases and peptidases. The compounds and gels synthesized therefrom can be used in such applications as tissue engineering, drug delivery, separation of biomolecules, and stimulus-responsive advanced materials
专利号:US-6054579-A 优先权日:1997-06-26 标 题:Synthesis of substituted lactams 发明人:HARRIMAN GERALDINE C B 权利人:LEUKOSITE INC 摘要:The invention relates to an efficient and facile method for the preparation of substituted lactams, as described herein. The method comprises reacting a difunctional component containing an activated carbon, an amine capable of forming an imine with the activated carbon of the difunctional component, and an isocyanide in a nucleophilic polar protic solvent and at a concentration of reactants which facilitates the formation of the substituted lactams. The invention also relates to novel substituted lactams, libraries comprising such lactams, and a method of generating libraries substituted lactams, using the method of the invention.
专利号:US-9533937-B2 优先权日:2013-12-31 标 题 :Use of metal scavengers for removal of ruthenium residues 发明人:SZCZEPANIAK GRZEGORZ; CZARNOCKI STEFAN J; SKOWERSKI KRZYSZTOF 权利人:APEIRON SYNTHESIS SA 摘要:The invention concerns use of metal scavengers of the formula (1), wherein the variables are as defined in the description of the invention, for removal of ruthenium residues, compounds, or complexes thereof, from the post-reaction mixtures, from the products of reactions catalyzed with ruthenium complexes, as well as from organic compounds contaminated with ruthenium.
专利号:WO-9900362-A1 优先权日:1997-06-26 标题:Synthesis of aminocarbonyl substituted lactams
专利号:US-9221042-B2 优先权日:2012-08-16 标题:Metal complexes, especially the ruthenium complexes, and use thereof 发明人:GRELA KAROL; TORBORG CHRISTIAN; SZCZEPANIAK GRZEGORZ; ZIELINSKI ADAM 权利人:APEIRON SYNTHESIS SA 摘要:Described herein are novel metal complexes, especially ruthenium complexes, represented by the formula (1): n nwherein L 1 is a N-heterocyclic carbene ligand, L 2 is a neutral phosphine ligand, preferably tricyclohexyl-phosphine, and process of catalyzing olefin metathesis reactions, especially tetra-substituted olefin metathesis reactions.