CAS: 78375-48-1; 2-Morpholinoethylisocyanide

该化合物是一种多用途异氰化物衍生物,主要用作有机合成和药用化学的构件,其甲状醇乙基组增强溶性性和稳定性,使其有利于Ugi和Passerini反应等多成分反应.同位素氰化物功能能够有效地融入复杂的分子框架,促进异性循环,皮质omimicic和生物活性化合物的合成.这种试剂因其与多种反应条件的兼容性及其在金属循环化中作为悬浮体的能力而特别受重视.其定义明确的再活动特征和结构特征使得它成为制药和材料科学应用研究人员的有用工具.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号78375-50-5 N-(2-morpholino... | CAS号87024-45-1 8-oxa-2,5-diaza... | CAS号87024-47-3 8-oxa-2,5-diaza... | CAS号92-53-5 4-苯基吗啉 | CAS号100-74-3 N-乙基吗啉 | CAS号3392-10-7 叔丁氧羰基-脯氨酰-琥珀酰亚胺

合成工艺路线路线简述

  • 合成目标产物 2-Morpholinoethyl Isocyanide 主要起始原料 Formamide, N-[2-(4-Morpholinyl)Ethyl]-
  • (文献来源)合成步骤主要原料 Formamide, N-[2-(4-Morpholinyl)Ethyl]-
📜Toluene-4-Sulfonate8-Oxa-2-Aza-5-Azonia-Spiro[4.5]Dec-1-Ene;置于sodium Hydroxide体系中,化学反应生成 2-吗啉基乙基异腈
参考文献:氨基异腈环化合成咪唑啉盐
标题:氨基异腈环化合成咪唑啉盐
摘要:
DOI:10.1007/bf00523090

海关参考信息

专利信息


专利号:US-2017320908-A1
优先权日:2014-11-19
标题 :Solid phase synthesis of cyclic amino acid molecules
发明人:HICKEY JENNIFER L; MANCUSO JOHN; MARSAULT ERIC; ROUGHTON ANDREW L; TREDER ADAM P; TREMBLEY MARIE-CLAUDE J; YUDIN ANDREI K; ZARETSKY SERGE
权利人:ENCYCLE THERAPEUTICS; GOVERNING COUNCIL OF THE UNIV OF TORONTO; UNIV SHERBROOKE
摘要:The present invention relates to cyclic amino acid molecules and methods of preparing the same, and in particular the macrocyclization of amino acids or linear peptides bound to a solid support.

专利号:US-2014296354-A1
优先权日:2013-04-01
标题 :Synthesis of peptoid-based small molecular gelators from multiple component reactions
发明人:WANG GUIJUN; MANGUNURU HARI P R
权利人:WANG GUIJUN; MANGUNURU HARI P R; OLD DOMINION UNIV RES FOUND
摘要:Described herein are the one-pot synthesis and characterization of a library of low molecular weight peptoid compounds that are able to form gels at room temperature. The compounds are synthesized from biologically-based starting materials, are biocompatible, and are resistant to degradation by proteases and peptidases. The compounds and gels synthesized therefrom can be used in such applications as tissue engineering, drug delivery, separation of biomolecules, and stimulus-responsive advanced materials

专利号:US-6054579-A
优先权日:1997-06-26
标 题:Synthesis of substituted lactams
发明人:HARRIMAN GERALDINE C B
权利人:LEUKOSITE INC
摘要:The invention relates to an efficient and facile method for the preparation of substituted lactams, as described herein. The method comprises reacting a difunctional component containing an activated carbon, an amine capable of forming an imine with the activated carbon of the difunctional component, and an isocyanide in a nucleophilic polar protic solvent and at a concentration of reactants which facilitates the formation of the substituted lactams. The invention also relates to novel substituted lactams, libraries comprising such lactams, and a method of generating libraries substituted lactams, using the method of the invention.

专利号:US-9533937-B2
优先权日:2013-12-31
标 题 :Use of metal scavengers for removal of ruthenium residues
发明人:SZCZEPANIAK GRZEGORZ; CZARNOCKI STEFAN J; SKOWERSKI KRZYSZTOF
权利人:APEIRON SYNTHESIS SA
摘要:The invention concerns use of metal scavengers of the formula (1), wherein the variables are as defined in the description of the invention, for removal of ruthenium residues, compounds, or complexes thereof, from the post-reaction mixtures, from the products of reactions catalyzed with ruthenium complexes, as well as from organic compounds contaminated with ruthenium.

专利号:WO-9900362-A1
优先权日:1997-06-26
标题:Synthesis of aminocarbonyl substituted lactams

专利号:US-9221042-B2
优先权日:2012-08-16
标题:Metal complexes, especially the ruthenium complexes, and use thereof
发明人:GRELA KAROL; TORBORG CHRISTIAN; SZCZEPANIAK GRZEGORZ; ZIELINSKI ADAM
权利人:APEIRON SYNTHESIS SA
摘要:Described herein are novel metal complexes, especially ruthenium complexes, represented by the formula (1): n nwherein L 1 is a N-heterocyclic carbene ligand, L 2 is a neutral phosphine ligand, preferably tricyclohexyl-phosphine, and process of catalyzing olefin metathesis reactions, especially tetra-substituted olefin metathesis reactions.

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Riva, R.; Banfi, L.; Basso, A., Science of Synthesis: Multicomponent Reactions, (2013) 1, 358.
摘要:Shaabani, A.; Sarvary, A.; Shaabani, S., Science of Synthesis: Multicomponent Reactions, (2013) 2, 64.
摘要:Shaabani, A.; Sarvary, A.; Shaabani, S., Science of Synthesis: Multicomponent Reactions, (2013) 2, 55.
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