CAS: 73943-41-6; 2-Fluoro-6-Methoxyphenol

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1-fluoro-3-methoxybenzene 1-fluoro-2,3-dimethoxybenzene 2-benzyloxy-3-fluoroanisole 2-(benzyloxy)-3-fluorophenol 2-fluoro-3-hydroxy-4-methoxybenzaldehyde 3-fluor°C atechol 2'-fluoro-6'-methoxyphenyl acridine-9-carboxylate 2-(2-fluoro-6-methoxyphenoxy)-1-bromoethane

📜间氟苯甲醚 反应生成 2-氟-6-甲氧基苯酚
参考文献:4-氟,7-氟和4,7-二氟-5,6-二羟基色胺的合成和生物学评估.
标题:4-氟,7-氟和4,7-二氟-5,6-二羟基色胺的合成和生物学评估.
摘要:合成了5,6-二羟基色胺(5,6-Dht)衍生物4-氟-和7-氟-5,6-Dht(26A,B)和4,7-二氟-5,6-Dht(26C)分别由3-氟茴香醚(1)和1,4-二氟-2,3-二甲氧基苯(13)制成.已开发出有效的方法,用于将1转化为4-氟-和7-氟-5,6-双(苄氧基)吲哚(分别为12A,B)和从13转化为4,7-二氟-5,6-[(二苯基亚甲基)二氧基]吲哚(19)是由2-硝基甲苯就地制备的2-硝基-β-(二烷基氨基)苯乙烯的还原环化反应.然后通过相应的吲哚-3-乙腈将吲哚12A,B和19转化为26A-C.用分光光度法测定,氟取代的5,6-Dhts显示出增加的苯酚酸度,并且通过循环伏安法测定,其发生氧化的固有电势降低.从抑制26A,C和5,6-Dht的ic50值分别得出117,125,135和92 Microm的ic50值判断,氟取代对细胞毒性潜能没有明显的不利影响,从而抑制了
DOI:10.1021/jm00170A026

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2011104055-A1
优先权日:2002-05-31
标题:Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies
发明人：SNOW ALAN; WEIGELE MANFRED; LARSEN LESLEY; NGUYEN BETH; LAKE THOMAS; CASTILLO GERARDO; SANDERS VIRGINIA; WEAVERS REX T; LORIMER STEPHEN; LARSEN DAVID; COFFEN DAVID L; COFFEN CHARLOTTE
权利人:SNOW ALAN; WEIGELE MANFRED; LARSEN LESLEY; NGUYEN BETH; LAKE THOMAS; CASTILLO GERARDO; SANDERS VIRGINIA; WEAVERS REX T; LORIMER STEPHEN; LARSEN DAVID; COFFEN DAVID L; COFFEN CHARLOTTE
摘要:Compounds and their pharmaceutically acceptable salts, their synthesis and labeling, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided. Also provided is the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of amyloid and synuclein.

专利号:WO-2009081259-A1
优先权日:2007-12-21
标题 :Phenoxy-pyridyl derivatives
发明人：BARTA NANCY SUE; CAMPBELL BRIAN MICHAEL; DOUNAY AMY BETH; GRAY DAVID LAWRENCE FIRMAN; ZORN STEVIN HOWARD
权利人:PFIZER; BARTA NANCY SUE; CAMPBELL BRIAN MICHAEL; DOUNAY AMY BETH; GRAY DAVID LAWRENCE FIRMAN; ZORN STEVIN HOWARD
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.